Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma
Yıl: 2019 Cilt: 20 Sayı: 3 Sayfa Aralığı: 202 - 207 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2018.82195 İndeks Tarihi: 16-04-2020
Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma
Öz: Introduction: It has been shown that the host immune responseand chronic inflammation could play a role as important riskfactors for cancer. Oral squamous cell carcinoma (OSCC) is acommon cancer worldwide. In this study, we aimed to evaluatethe impact of interleukin-1 receptor antagonist (IL-1RA) andIL-4 variable number tandem repeat (VNTR) polymorphismson OSCC susceptibility in a Turkish population.Methods: Study subjects comprised of 36 OSCC patientsand 100 healthy controls. Genotyping of the IL-1RA VNTR(rs2234663) and IL-4 VNTR (rs79071878) polymorphisms wereanalyzed by polymerase chain reaction.Results: The frequency of IL-1RA VNTR 1/2+2/2 genotypesincreased in the patients than healthy controls while IL-1RAVNTR 1/1 genotype was higher in the control group than in thepatients (p=0.002). The subjects carrying IL-1RA VNTR 1/2+2/2genotypes showed a 12.011-fold increased risk of susceptibilityto OSCC. IL-1RA VNTR allele 1 was higher in the control groupthan the patient group while IL-1RA VNTR allele 2 was higher inthe patient group than the control group (respectively, p=0.000,p=0.000). The subjects carrying IL-1RA VNTR allele 2 showeda 2.609-fold increased risk of susceptibility to OSCC. The IL-4VNTR P1/P1 and P1/P2 genotype frequencies were higher inthe patient group compared to the control group (p=0.039).IL-4 VNTR P1 allele was higher in the patients compared to thecontrols (p=0.030).Conclusion: The significant association between thefunctional VNTR polymorphisms of IL-1RA/IL-4 genes andOSCC suspectibility in a Turkish population confirmed a role ofaltered inflammatory process in OSCC pathogenesis.
Anahtar Kelime: Konular:
Interlökin-1 Reseptörü Antagonisti ve Interlökin-4 Gen Fonksiyonel VNTR Varyantlarının Oral Skuamöz Hücreli Karsinoma Etkisi
Öz: Amaç: Konakçı immün cevabının ve kronik enflamasyonun kanser için önemli risk faktörleri olarak rol oynadığı gösterilmiştir. Oral skuamöz hücreli kanser (OSHK) tüm dünyada yaygın bir kanser türüdür. Bu çalışmada Türk toplumunda interlökin-1 reseptörü antagonisti (IL-1RA) ve IL-4 değişken sayılı ardışık tekrar (VNTR) polimorfizminin OSHK yatkınlığına olan etkisini incelemeyi amaçladık. Yöntemler: Çalışma grubu 36 OSHK hastası ve 100 sağlıklı kontrolden oluşmaktadır. IL-1RA VNTR (rs2234663) ve IL-4 VNTR (rs79071878) polimorfizmlerinin genotiplemesi polimeraz zincirleme tepkimesi ile analiz edildi. Bulgular: IL-1RA VNTR 1/1 genotipi kontrol grubunda hastalardan daha fazla iken IL-1RA VNTR 1/2+2/2 genotipleri hastalarda sağlıklı kontrollere göre artmıştı (p=0,002). IL-1RA VNTR 1/2+2/2 genotiplerini taşıyan kişiler OSHK’ye yatkınlık yönünden 12,011 kat fazla risk gösterdiler. IL-1RA VNTR allel 2 hasta grubunda kontrol grubundan daha fazla iken IL-1RA VNTR allel 1 kontrol grubunda hasta grubundan daha fazlaydı (sırasıyla, p=0,000, p=0,000). IL-1RA VNTR allel 2 taşıyan kişiler OSHK’ye yatkınlık yönünden 2,609 kat fazla risk gösterdiler. IL-4 VNTR P1/P1 ve P1/P2 genotip sıklığı hasta grubunda kontrol grubuna göre daha fazlaydı (p=0,039). IL-4 VNTR P1 alleli hastalarda kontrollere göre daha yüksekti (p=0,030). Sonuç: Türk popülasyonundaki IL-1RA/IL-4 VNTR polimorfizmleri ve OSHK yatkınlığı arasındaki önemli ilişki OSHK etiyopatogenezinde değişen enflamatuvar işlevlerin rolü olduğunu doğrulamıştır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gumusay O, Nursal A, YİĞİT S, TEKCAN A (2019). Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. , 202 - 207. 10.4274/imj.galenos.2018.82195 |
| Chicago | Gumusay Ozge,Nursal Ayse Feyda,YİĞİT Serbülent,TEKCAN AKIN Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. (2019): 202 - 207. 10.4274/imj.galenos.2018.82195 |
| MLA | Gumusay Ozge,Nursal Ayse Feyda,YİĞİT Serbülent,TEKCAN AKIN Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. , 2019, ss.202 - 207. 10.4274/imj.galenos.2018.82195 |
| AMA | Gumusay O,Nursal A,YİĞİT S,TEKCAN A Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. . 2019; 202 - 207. 10.4274/imj.galenos.2018.82195 |
| Vancouver | Gumusay O,Nursal A,YİĞİT S,TEKCAN A Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. . 2019; 202 - 207. 10.4274/imj.galenos.2018.82195 |
| IEEE | Gumusay O,Nursal A,YİĞİT S,TEKCAN A "Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma." , ss.202 - 207, 2019. 10.4274/imj.galenos.2018.82195 |
| ISNAD | Gumusay, Ozge vd. "Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma". (2019), 202-207. https://doi.org/10.4274/imj.galenos.2018.82195 |
| APA | Gumusay O, Nursal A, YİĞİT S, TEKCAN A (2019). Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. İstanbul Medical Journal, 20(3), 202 - 207. 10.4274/imj.galenos.2018.82195 |
| Chicago | Gumusay Ozge,Nursal Ayse Feyda,YİĞİT Serbülent,TEKCAN AKIN Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. İstanbul Medical Journal 20, no.3 (2019): 202 - 207. 10.4274/imj.galenos.2018.82195 |
| MLA | Gumusay Ozge,Nursal Ayse Feyda,YİĞİT Serbülent,TEKCAN AKIN Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. İstanbul Medical Journal, vol.20, no.3, 2019, ss.202 - 207. 10.4274/imj.galenos.2018.82195 |
| AMA | Gumusay O,Nursal A,YİĞİT S,TEKCAN A Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. İstanbul Medical Journal. 2019; 20(3): 202 - 207. 10.4274/imj.galenos.2018.82195 |
| Vancouver | Gumusay O,Nursal A,YİĞİT S,TEKCAN A Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma. İstanbul Medical Journal. 2019; 20(3): 202 - 207. 10.4274/imj.galenos.2018.82195 |
| IEEE | Gumusay O,Nursal A,YİĞİT S,TEKCAN A "Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma." İstanbul Medical Journal, 20, ss.202 - 207, 2019. 10.4274/imj.galenos.2018.82195 |
| ISNAD | Gumusay, Ozge vd. "Impact of the Functional VNTR Variants of the Interleukin-1 Receptor Antagonist and Interleukin-4 Genes on Oral Squamous Cell Carcinoma". İstanbul Medical Journal 20/3 (2019), 202-207. https://doi.org/10.4274/imj.galenos.2018.82195 |
