A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes
Yıl: 2019 Cilt: 20 Sayı: 3 Sayfa Aralığı: 253 - 255 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2018.75735 İndeks Tarihi: 16-04-2020
A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes
Öz: The number of patients with type 2 diabetes using dipeptidylpeptidase-4 (DPP-4) inhibitors is increasing across the world.Although this class of antidiabetic medications is generallysafe and associated with less side effects compared to otheroral antidiabetic medications, they could also cause some sideeffects such as skin rashes. Herein we report a case of type 2diabetes patient who developed a painful maculopapular rashinduced by linagliptin, a widely used DPP-4 inhibitor.A localized painful maculopapular rash developed on thepalmar faces of the patient’s hands almost 1 day after theinitiation of the drug. The patient was using intensive insulintherapy before linagliptin was started. There was no eruptionon the other body parts except the palmar faces of the hands.Following the discontinuation of the drug, the rash disappearedin about four days. The patient had no history of urticaria anddid not use an ACE inhibitor. As far as we know, this is the firstcase report of a skin rash induced by linagliptin in the Turkishliterature. This case report highlights a rare and lesser knownside effect of linagliptin, a new member of DPP-4 inhibitors.
Anahtar Kelime: Konular:
Tip 2 Diyabetli Bir Hastada Linagliptine Bağlı Lokalize Ağrılı Döküntü
Öz: Dipeptidil peptidaz-4 (DPP-4) inhibitörleri kullanan tip 2 diyabet hastalarının sayısı dünya genelinde artmaktadır. Bu antidiyabetik ilaç sınıfı genelde güvenli olmakla birlikte diğer oral antidiyabetik ilaçlarla karşılaştırıldığında daha az yan etki ile ilişkili olsa da, deri döküntüleri gibi bazı yan etkilerle ilişkili olabilirler. Burada yaygın olarak kullanılan bir DPP-4 inhibitörü olan linagliptin ile indüklenen ağrılı makülopapüler döküntü gelişen tip 2 diyabetli bir hastayı sunuyoruz. Linagliptin başlandıktan 1 gün sonra hastamızın ellerinin palmar yüzünde lokalize ağrılı makülopapüler bir döküntü gelişti. Linagliptin başlanmadan önce hasta intensif insülin tedavisi altındaydı. Vücudun diğer bölgelerinde herhangi bir döküntü yoktu. Linagliptin kesildikten sonra 4 gün içerisinde döküntü kayboldu. Hastanın ürtiker öyküsü yoktu ve Anjiyotensin dönüştürücü enzim inhibitörü kullanmıyordu. Bildiğimiz kadarıyla bu, Türk literatüründe Linagliptine bağlı deri döküntüsü geliştirdiği rapor edilen ilk olgudur. Bu olgu sunumu, DPP-4 inhibitörlerinin nadir görülen ve daha az bilinen bir yan etkisini vurgulamaktadır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | YILDIZ İ, Gen R, BATMAZ L, Sezer K, AKBAY E, İBANOĞLU M, yuyucu karabulut y (2019). A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. , 253 - 255. 10.4274/imj.galenos.2018.75735 |
| Chicago | YILDIZ İSMAİL,Gen Ramazan,BATMAZ Leyla,Sezer Kerem,AKBAY Esen,İBANOĞLU Mahmut Serbülent,yuyucu karabulut yasemin A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. (2019): 253 - 255. 10.4274/imj.galenos.2018.75735 |
| MLA | YILDIZ İSMAİL,Gen Ramazan,BATMAZ Leyla,Sezer Kerem,AKBAY Esen,İBANOĞLU Mahmut Serbülent,yuyucu karabulut yasemin A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. , 2019, ss.253 - 255. 10.4274/imj.galenos.2018.75735 |
| AMA | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. . 2019; 253 - 255. 10.4274/imj.galenos.2018.75735 |
| Vancouver | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. . 2019; 253 - 255. 10.4274/imj.galenos.2018.75735 |
| IEEE | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y "A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes." , ss.253 - 255, 2019. 10.4274/imj.galenos.2018.75735 |
| ISNAD | YILDIZ, İSMAİL vd. "A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes". (2019), 253-255. https://doi.org/10.4274/imj.galenos.2018.75735 |
| APA | YILDIZ İ, Gen R, BATMAZ L, Sezer K, AKBAY E, İBANOĞLU M, yuyucu karabulut y (2019). A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. İstanbul Medical Journal, 20(3), 253 - 255. 10.4274/imj.galenos.2018.75735 |
| Chicago | YILDIZ İSMAİL,Gen Ramazan,BATMAZ Leyla,Sezer Kerem,AKBAY Esen,İBANOĞLU Mahmut Serbülent,yuyucu karabulut yasemin A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. İstanbul Medical Journal 20, no.3 (2019): 253 - 255. 10.4274/imj.galenos.2018.75735 |
| MLA | YILDIZ İSMAİL,Gen Ramazan,BATMAZ Leyla,Sezer Kerem,AKBAY Esen,İBANOĞLU Mahmut Serbülent,yuyucu karabulut yasemin A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. İstanbul Medical Journal, vol.20, no.3, 2019, ss.253 - 255. 10.4274/imj.galenos.2018.75735 |
| AMA | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. İstanbul Medical Journal. 2019; 20(3): 253 - 255. 10.4274/imj.galenos.2018.75735 |
| Vancouver | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes. İstanbul Medical Journal. 2019; 20(3): 253 - 255. 10.4274/imj.galenos.2018.75735 |
| IEEE | YILDIZ İ,Gen R,BATMAZ L,Sezer K,AKBAY E,İBANOĞLU M,yuyucu karabulut y "A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes." İstanbul Medical Journal, 20, ss.253 - 255, 2019. 10.4274/imj.galenos.2018.75735 |
| ISNAD | YILDIZ, İSMAİL vd. "A Localized Painful Rash Induced by Linagliptin in a Patient with type 2 Diabetes". İstanbul Medical Journal 20/3 (2019), 253-255. https://doi.org/10.4274/imj.galenos.2018.75735 |
