Celiac disease is an autoimmune disease caused by gluten in genetically predisposed individuals. In addition to classical symptoms, it may occur at any age with atypical findings affecting many systems. The most common extraintestinal finding is iron deficiency anemia. The prevalence of the disease of first-degree relatives of celiac patients was higher than the general population. Anti-gliadin, anti-endomysium and anti-tissue transglutaminase antibodies are first used in the diagnosis. The gold standard is the small intestine biopsy. The risk of complication development is reduced with early diagnosis, diet and replacement therapy. The clinic can be very variable. Therefore, it is very important to suspect the diagnosis of family physicians working in primary care. In this paper, were reported two cases from the same family who were application to family medicine outpatient clinic with diarrhea and abdominal pain in addition to chronic iron deficiency anemia, were diagnosed in adult.