Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke

KAZANCI, Ülkü; seyithanoğlu, muhammed; Altıntaş Aykan, Duygun

Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke

Duygun ALTINTAŞ AYKAN, (Kahramanmaraş Sütçü İmam Üniversitesi)

Muhammed SEYİTHANOĞLU, (Kahramanmaraş Sütçü İmam Üniversitesi)

Ülkü KAZANCI (Kahramanmaraş Sütçü İmam Üniversitesi)

Erciyes Medical Journal

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Yıl: 2019 Cilt: 41 Sayı: 4 Sayfa Aralığı: 429 - 434 Metin Dili: İngilizce İndeks Tarihi: 17-04-2020

Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke

Öz:

Objective: Currently, there is uncertainty about the increased risk of myocardial infarction following ischemic stroke or transientischemic attack and the method of risk management after the stroke. In this experimental study, we aimed to evaluatemyocardial injury after inducing global cerebral ischemia in rats and assess their responses to the treatments with diseasemodifyingantirheumatic drugs (DMARDs) and ischemic postconditioning (PC).Materials and Methods: Global cerebral ischemia was induced by occluding the bilateral common carotid arteries for20 minutes and subsequently reperfusing them. Thirty-two Wistar rats were divided into 4 treatment groups (n=8 for eachgroup). Group I received 7 mg/kg/day infliximab immediately and at 6 hours after the stroke and group II received 10 mg/kg/day leflunomide immediately and at 6 hours after the stroke. In group III, the skeletal muscle in the limbs was clamped for180 minutes immediately after the stroke and was reperfused for 120 minutes. Group IV was sham-operated and receivedsaline immediately and at 6 hours after the stroke. Myocardium tissue samples were collected for histopathologic assays andto create hypoxia-induced tissue oxidative markers.Results: We found that apoptosis and nucleus loss in the myocardium were significantly decreased after the administrationof infliximab, leflunomide, and remote ischemic PC. Necrosis in the myocardium and cardiac malondialdehyde (MDA) levelwere also significantly decreased after treatment with remote skeletal muscle PC.Conclusion: Our findings demonstrated that remote ischemic PC and DMARDs were protective against cerebral ischemia/reperfusion injury. They acted by mobilizing the endogenous adaptive mechanisms in the myocardium and inhibited oxidativestress by increasing the activity of antioxidant enzymes.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Altıntaş Aykan D, seyithanoğlu m, KAZANCI Ü (2019). Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. , 429 - 434.
Chicago	Altıntaş Aykan Duygun,seyithanoğlu muhammed,KAZANCI Ülkü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. (2019): 429 - 434.
MLA	Altıntaş Aykan Duygun,seyithanoğlu muhammed,KAZANCI Ülkü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. , 2019, ss.429 - 434.
AMA	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. . 2019; 429 - 434.
Vancouver	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. . 2019; 429 - 434.
IEEE	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü "Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke." , ss.429 - 434, 2019.
ISNAD	Altıntaş Aykan, Duygun vd. "Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke". (2019), 429-434.

APA	Altıntaş Aykan D, seyithanoğlu m, KAZANCI Ü (2019). Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. Erciyes Medical Journal, 41(4), 429 - 434.
Chicago	Altıntaş Aykan Duygun,seyithanoğlu muhammed,KAZANCI Ülkü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. Erciyes Medical Journal 41, no.4 (2019): 429 - 434.
MLA	Altıntaş Aykan Duygun,seyithanoğlu muhammed,KAZANCI Ülkü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. Erciyes Medical Journal, vol.41, no.4, 2019, ss.429 - 434.
AMA	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. Erciyes Medical Journal. 2019; 41(4): 429 - 434.
Vancouver	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke. Erciyes Medical Journal. 2019; 41(4): 429 - 434.
IEEE	Altıntaş Aykan D,seyithanoğlu m,KAZANCI Ü "Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke." Erciyes Medical Journal, 41, ss.429 - 434, 2019.
ISNAD	Altıntaş Aykan, Duygun vd. "Disease-Modifying Antirheumatic Drugs and Remote Ischemic Postconditioning Ameliorate for Myocardial Injury in Rats Under Cerebral Stroke". Erciyes Medical Journal 41/4 (2019), 429-434.