Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer

Sanlier, Nevin; ÖZATA UYAR, GİZEM

doi:10.5152/eurasianjmed.2018.18089

Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer

GİZEM ÖZATA UYAR, (Gazi Üniversitesi)

NEVİN ŞANLIER (Lokman Hekim Üniversitesi)

Eurasian Journal of Medicine

1 0

Yıl: 2019 Cilt: 51 Sayı: 2 Sayfa Aralığı: 191 - 195 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2018.18089 İndeks Tarihi: 24-04-2020

Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer

Öz:

Obesity-related diseases are an important part of public health; and obesity is related with colorectal cancer. Adipocyte hypertrophy and visceral adipose tissue accumulation can cause adipocitis-related diseases and pathogenic adipocyte formation. Adipose tissue has a very important and active role in immune response formation. Cytokines/adipokines, which are secreted from adipose tissue, have an active role in communication between adipocytes and macrophages. Thus, visceral adipocyte is related with low-grade chronic systemic inflammation. Adipocytes have an important role in colorectal cancer pathogenesis because of proinflammatory cytokines, growth factors, and hormones secretion. Most highlighted cytokines are adiponectin, resistin, and ghrelin. Also, insulin resistance, glucose intolerance, increased plasma insulin levels, body mass index, insulin-like growth factor (IGF-1), glucose, and serum free fatty acids levels are considered to be related with colorectal cancer pathogenesis. Thus, in this review, we focus on the role of adipokines and insulin in colorectal cancer.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	ÖZATA UYAR G, Sanlier N (2019). Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. , 191 - 195. 10.5152/eurasianjmed.2018.18089
Chicago	ÖZATA UYAR GİZEM,Sanlier Nevin Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. (2019): 191 - 195. 10.5152/eurasianjmed.2018.18089
MLA	ÖZATA UYAR GİZEM,Sanlier Nevin Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. , 2019, ss.191 - 195. 10.5152/eurasianjmed.2018.18089
AMA	ÖZATA UYAR G,Sanlier N Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. . 2019; 191 - 195. 10.5152/eurasianjmed.2018.18089
Vancouver	ÖZATA UYAR G,Sanlier N Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. . 2019; 191 - 195. 10.5152/eurasianjmed.2018.18089
IEEE	ÖZATA UYAR G,Sanlier N "Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer." , ss.191 - 195, 2019. 10.5152/eurasianjmed.2018.18089
ISNAD	ÖZATA UYAR, GİZEM - Sanlier, Nevin. "Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer". (2019), 191-195. https://doi.org/10.5152/eurasianjmed.2018.18089

APA	ÖZATA UYAR G, Sanlier N (2019). Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. Eurasian Journal of Medicine, 51(2), 191 - 195. 10.5152/eurasianjmed.2018.18089
Chicago	ÖZATA UYAR GİZEM,Sanlier Nevin Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. Eurasian Journal of Medicine 51, no.2 (2019): 191 - 195. 10.5152/eurasianjmed.2018.18089
MLA	ÖZATA UYAR GİZEM,Sanlier Nevin Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. Eurasian Journal of Medicine, vol.51, no.2, 2019, ss.191 - 195. 10.5152/eurasianjmed.2018.18089
AMA	ÖZATA UYAR G,Sanlier N Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. Eurasian Journal of Medicine. 2019; 51(2): 191 - 195. 10.5152/eurasianjmed.2018.18089
Vancouver	ÖZATA UYAR G,Sanlier N Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer. Eurasian Journal of Medicine. 2019; 51(2): 191 - 195. 10.5152/eurasianjmed.2018.18089
IEEE	ÖZATA UYAR G,Sanlier N "Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer." Eurasian Journal of Medicine, 51, ss.191 - 195, 2019. 10.5152/eurasianjmed.2018.18089
ISNAD	ÖZATA UYAR, GİZEM - Sanlier, Nevin. "Association of Adipokines and Insulin, Which Have a Role in Obesity, with Colorectal Cancer". Eurasian Journal of Medicine 51/2 (2019), 191-195. https://doi.org/10.5152/eurasianjmed.2018.18089