Yıl: 2019 Cilt: 51 Sayı: 3 Sayfa Aralığı: 237 - 241 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2019.18306 İndeks Tarihi: 24-04-2020

The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder

Öz:
Objective: Optical coherence tomography (OCT) is an increasingly used new method that investigates changes in the retinal nerve fiber layer (RNFL) in neurodegenerative diseases. It provides high-resolution cross-sectional imaging of biological tissues. This study aimed to investigate the structural changes in RNFL in patients with obsessive compulsive disorder (OCD) using OCT and to investigate the possible effects of retinal function on the etiopathogenesis of OCD.Materials and Methods: In this study, 30 patients diagnosed with OCD at the end of the Structured Clinical Interview for DSM (SCID-I), without any drug use status, and 31 healthy participants paired with the patients in terms of their sociodemographic characteristics were included. In the patient and control groups, the RNFL thickness was measured and compared at each locus using OCT.Results: Statistically significant differences were found in RNFL, ganglion cell layer thickness, and central foveal thickness between the patients with OCD and the control group. In this study, the choroidal thickness values of the patient group were found to be higher than those of the control group; and a statistically significant difference was observed in the mean choroidal thickness values (p=0.045).Conclusion: The findings of the study suggest that the RNFL thickness of patients with OCD does not decrease, but choroidal thickness may be an important biomarker to determine the etiopathogenesis of the disease and follow neurodegeneration.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Bayar R. Continuing Medical Education Activities in Istanbul University Cerrahpasa School of Medicine. Symposium Series of Common Psychiatric Disorders in Turkey 2008; 3: 185-192. (Turkish)
  • 2. London A, Benhar I, Schwartz M. The retina as a window to the brain-from eye research to CNS disorders. Nat Rev Neurol 2013; 5: 44-53. [CrossRef]
  • 3. Galetta KM, Calabresi PA, Frohman EM, Balcer LJ. Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration. Neuro therapeutics 2011; 2: 117-132. [CrossRef]
  • 4. Simao LM. The contribution of optical coherence tomography in neuro degenerative diseases. Curr Opin Ophthalmol 2013; 4: 521-7. [CrossRef]
  • 5. Robinson D, Wu H, Munne RA, et al. Reduced caudate nucleus volume in obsessive-compulsive disorder. Arch Gen Psychiatry 1995; 52: 393-8. [CrossRef]
  • 6. Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl 1998; 173: 26-37. [CrossRef]
  • 7. Behar D, Rapoport JL, Berg CJ, et al. Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder. Am J Psychiatry 1984; 141: 363-9. [CrossRef]
  • 8. Zohar J, Hermesh H, Weizman A Voet H, Gross-Isseroff R. Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? I. Alternation learning in obsessive-compulsive disorder: malefemale comparisons. Eur Neuropsychopharmacol 1999; 9: 407- 13. [CrossRef]
  • 9. Tomer R, Levin BE, Weiner WJ. Obsessive compulsive symptoms and motor asymmetries in Parkinson's disease. Neuropsychiatry Neuropsychol Behav Neurol 1993; 6: 26-30.
  • 10. Tian T, Zhu XH, Liu YH. Potential role of retina as a biomarker for progression of Parkinson's disease. Int J Ophthalmol 2011; 5: 433-8.
  • 11. Lee WW, Tajunisah I, Sharmilla K, Peyman M, Subrayan V. Retinal nerve fiber layer structure abnormalities in schizophrenia and its relationship to disease state: evidence from optical coherence tomography. Invest Ophthalmol Vis Sci 2013; 23: 7785-92. [CrossRef]
  • 12. Chu EM, Kolappan M, Barnes TR, Joyce EM, Ron MA. A window into the brain: an invivo study of the retina in schizophrenia using optical coherence tomography. Psychiatry Res 2012; 6: 89-94. [CrossRef]
  • 13. Kemenyova P, Turcani P, Sutovsky S, Waczulikova I. Optical coherence tomography and its use in optical neuritis and multiple sclerosis. Bratisl Lek Listy 2014; 2: 723-729. [CrossRef]
  • 14. Berggren N, Richards A, Taylor J, Derakshan N. Affective atten¬tion under cognitive load: reduced emotional biases but emergent anxiety-related costs to inhibitory control. Front Hum Neurosci 2013; 7: 188. [CrossRef]
  • 15. Robinson OJ, Krimsky M, Grillon C. The impact of induced anxiety on response inhibition. Front Hum Neurosci 2013; 6: 7: 69.
  • 16. La Morgia C, Di Vito L, Carelli V, Carbonelli M. Patterns of retinal ganglion cell damage in neurodegenerative disorders: Parvocellular vs magnocellular degeneration in OCT studies. Front Neurol 2017; 12: 8: 710. [CrossRef]
  • 17. Doustar J, Torbati T, Black KL, Koronyo Y, Koronyo-Hamaoui M. Optical coherence tomography in Alzheimer's disease and other neurodegenerative diseases. Front Neurol 2017; 19: 8: 701. [CrossRef]
  • 18. Akaishi T, Kaneko K, Himori N, et al. Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica. J Neuroimmunol 2017; 5: 10-5. [CrossRef]
  • 19. Langwińska-Wośko E, Litwin T, Dzieżyc K, Karlinski M, Członkowska A. Optical coherence tomography as a marker of neurodegeneration in patients with Wilson's disease. Acta Neurol Belg 2017; 4: 867-71. [CrossRef]
  • 20. Schönfeldt-Lecuona C, Schmidt A, Kregel T. Retinal changes in patients with major depressive disorder - A controlled optical coherence tomography study. J Affect Disord 2017; 2: 665-71. [CrossRef]
  • 21. Samani NN, Proudlock FA, Siram V. Retinal layer abnormalities as biomarkers of schizophrenia. Schizophr Bull 2018; 44: 876-85. [CrossRef]
  • 22. Sonmez I, Koşger F, Aykan U. Retinal Nerve Fiber Layer Thickness measurement by Spectral-Domain Optical Coherence Tomography in patients with major depressive disorder. Noro Psikiyatr Ars 2017; 3: 62-6. [CrossRef]
  • 23. Noh HJ, Tang R, Flannick J. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nat Commun 2017; 4: 774-7. [CrossRef]
  • 24. Van de Vondervoort I, Poelmans G, Aschrafi A. An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder. J Psychiatry Neurosci 2016; 5: 280-5. [CrossRef]
  • 25. Heinzel S, Kaufmann C, Grützmann R. Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder. Neuroimage Clin 2017; 8: 426-34.
  • 26. Ozen ME, Kalenderoglu A, Karadag AS, Orum MH. Comparison of optic coherence tomography results in patients diagnosed with OCD: findings in favor of neurodegeneration. Anadolu Psikiyatri Derg 2019; 20: 166-74. [CrossRef]
  • 27. First MB, Spitzer RL, Gibbon M. Structred clinical interviewfor DSM-IV clinical version (SCID-I/ CV).Washington DC: American Psychiatric Pres; 1997.
  • 28. Özkürkçügil A, Aydemir Ö,Yıldız M. The reliability and validity of the Turkish Version of the Structured Clinical Interview for DSM-IV. İlaç ve Tedavi Dergisi 1999; 2: 233-36.
  • 29. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL et al. The Yale-Brown Obsessive Compulsive Scale, I: Development, use and reliability. Arch Gen Psychiatry 1989; 46: 1006-11. [CrossRef]
  • 30. Karamustafalıoğlu KO, Üçışık AM, Ulusoy M. The validity and reliability study of the Yale-Brown Obsession-Compulsive Scale. Bursa, Savaş Ofset, 1993; p.86.
  • 31. Tek C, Ulug B, Rezaki BG. Yale-Brown Obsessive Compulsive Scale and US National Institute of Mental Health Global Obsessive Compulsive Scale in Turkish: Reliability and validity. Acta Psychiatr Scand 1995; 2: 410-3. [CrossRef]
  • 32. London A, Benhar I, Schwartz M. The retina as a window to the brain-from eye research to CNS disorders. Nat Rev Neurol 2013; 3: 44-53. [CrossRef]
  • 33. Galetta KM, Calabresi PA, Frohman EM, Balcer LJ. Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration. Neurotherapeutics 2011; 3: 117-32. [CrossRef]
  • 34. Simao LM. The contribution of optical coherence tomography in neurodegenerative diseases. Curr Opin Ophthalmol 2013; 4: 521-7. [CrossRef]
  • 35. Celik M, Kalenderoglu A, Karadag AS, Egilmez BO, Han-Almis B, Şimşek A. Decreases in ganglion cell layer and inner plexiform layer volumes correlate better with disease severity in schizophrenia patients than retinal nerve fiber layer thickness: Findings from spectral optic coherence tomography. Eur Psychiatry 2016; 32: 9-15. [CrossRef]
  • 36. Jindahra P, Hedges TR, Mendoza-Santiesteban CE, Plant GT. Optical coherence tomography of the retina: applications in neurology. Curr Opin Neurol 2010; 7: 16-23. [CrossRef]
  • 37. Mehraban A, Samimi SM, Entezari M, Seifi MH, Nazari M, Yaseri M. Peripapillary retinal nerve fiber layer thickness in bipolar disorder. Graefes Arch Clin Exp Ophthalmol 2016; 2: 365-71. [CrossRef]
  • 38. Kalenderoglu A, Karadag AS, Celik M, Egilmez OB, Han-Almis B, Ozen ME. Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder? Compr Psychiatry 2016; 67: 66-72. [CrossRef]
  • 39. Tükel R. Cognitive functions in obsessive compulsive disorder. Turkiye Klinikleri J Psychiatry-Special Topics 2012; 2: 43-8.
  • 40. Del Casale A, Kotzalidis GD, Rapinesi C. Functional neuroimaging in obsessive-compulsive disorder. Neuropsychobiology 2011; 12: 61-85. [CrossRef]
  • 41. Kloft L, Reuter B, Riesel A, Kathmann N. Impaired volitional saccade control: first evidence for a new candidate endophenotype in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 2013; 2: 215-22. [CrossRef]
  • 42. Atmaca M, Yildirim H, Ozdemir H, Koc M, Ozler S, Tezcan E. Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 2009; 63: 486-90. [CrossRef]
  • 43. Honrubia F, Calonge B. Evaluation of the nerve fiber layer and peripapillary atrophy in ocular hypertension. Int Ophthalmol 1989; 2: 57-62. [CrossRef]
  • 44 Lee WW, Tajunisah I, Sharmilla K, Peyman M, Subrayan V. Retinal nerve fiber layer structure abnormalities in schizophrenia and its relationship to disease state: evidence from optical coherence tomography. Invest Ophthalmol Vis Sci 2013; 12: 7785-92. [CrossRef]
  • 45. Kalenderoglu A, Celik M, Karadag AS, Egilmez OB. Optic coherence tomography shows inflammation and degeneration in major depressive disorder patients correlated with disease severity. J Affect Disord 2016; 204: 159-65. [CrossRef]
APA Polat S, ŞEKERYAPAN GEDİZ B, ERCAN A, KAIM M, HOCAOĞLU Ç (2019). The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. , 237 - 241. 10.5152/eurasianjmed.2019.18306
Chicago Polat Selim,ŞEKERYAPAN GEDİZ BERRAK,ERCAN Alaattin Cenk,KAIM Muhammet,HOCAOĞLU Çiçek The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. (2019): 237 - 241. 10.5152/eurasianjmed.2019.18306
MLA Polat Selim,ŞEKERYAPAN GEDİZ BERRAK,ERCAN Alaattin Cenk,KAIM Muhammet,HOCAOĞLU Çiçek The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. , 2019, ss.237 - 241. 10.5152/eurasianjmed.2019.18306
AMA Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. . 2019; 237 - 241. 10.5152/eurasianjmed.2019.18306
Vancouver Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. . 2019; 237 - 241. 10.5152/eurasianjmed.2019.18306
IEEE Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç "The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder." , ss.237 - 241, 2019. 10.5152/eurasianjmed.2019.18306
ISNAD Polat, Selim vd. "The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder". (2019), 237-241. https://doi.org/10.5152/eurasianjmed.2019.18306
APA Polat S, ŞEKERYAPAN GEDİZ B, ERCAN A, KAIM M, HOCAOĞLU Ç (2019). The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. Eurasian Journal of Medicine, 51(3), 237 - 241. 10.5152/eurasianjmed.2019.18306
Chicago Polat Selim,ŞEKERYAPAN GEDİZ BERRAK,ERCAN Alaattin Cenk,KAIM Muhammet,HOCAOĞLU Çiçek The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. Eurasian Journal of Medicine 51, no.3 (2019): 237 - 241. 10.5152/eurasianjmed.2019.18306
MLA Polat Selim,ŞEKERYAPAN GEDİZ BERRAK,ERCAN Alaattin Cenk,KAIM Muhammet,HOCAOĞLU Çiçek The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. Eurasian Journal of Medicine, vol.51, no.3, 2019, ss.237 - 241. 10.5152/eurasianjmed.2019.18306
AMA Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. Eurasian Journal of Medicine. 2019; 51(3): 237 - 241. 10.5152/eurasianjmed.2019.18306
Vancouver Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder. Eurasian Journal of Medicine. 2019; 51(3): 237 - 241. 10.5152/eurasianjmed.2019.18306
IEEE Polat S,ŞEKERYAPAN GEDİZ B,ERCAN A,KAIM M,HOCAOĞLU Ç "The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder." Eurasian Journal of Medicine, 51, ss.237 - 241, 2019. 10.5152/eurasianjmed.2019.18306
ISNAD Polat, Selim vd. "The Place of Optical Coherence Tomography in Patients with Obsessive Compulsive Disorder". Eurasian Journal of Medicine 51/3 (2019), 237-241. https://doi.org/10.5152/eurasianjmed.2019.18306