Yıl: 2020 Cilt: 52 Sayı: 1 Sayfa Aralığı: 47 - 51 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2020.19223 İndeks Tarihi: 01-07-2020

Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro)

Öz:
Objective: Diabetes mellitus (DM) is typically a disorder of carbohydrate, fat, and protein metabolism. Itdevelops due to a lack of or loss associated with insulin and/or resistance to insulin. Regarding complicationsof chemical substance use, drugs with few complications and high-reliability tannins are needed. This studyaimed to determine the effect and mechanism of action of Citrullus colocynthis extract on the formation ofglycated hemoglobin (HbA1c).Materials and Methods: A solution containing hemoglobin and glucose was incubated for 1, 2, 3, 4, 30,and 60 days by adding Citrullus colocynthis extract or glutathione. Quantitative measurement of HbA1c wasperformed using ion-exchange chromatography. Data were analyzed using ANOVA and two-way repeatedmeasures test. A p<0.05 was considered statistically significant.Results: The Citrullus colocynthis extract in hyperglycemic conditions and with increasing time reduced theformation of HbA1c and thus inhibited the production of glycated proteins. By increasing the time and afterinitiation of reaction of extract concentrations (0, 0.1, 0.3, 0.5, and 1 g/dL), presently, there was a significantdecrease in the formation of HbA1C compared to those in the control group (p<0.05). The decrease inglycation has been dose dependent.Conclusion: Therefore, Citrullus colocynthis could directly reduce the formation of HbA1c.
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APA noorozi Karimabad m, NIKNIA S, GOLNABADI M, POOR S, Hajizadeh M, MAHMOODI M (2020). Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). , 47 - 51. 10.5152/eurasianjmed.2020.19223
Chicago noorozi Karimabad mojgan,NIKNIA Sedigheh,GOLNABADI Mahdieh Bemani,POOR Shirin Fattah,Hajizadeh Mohammadreza,MAHMOODI Mehdi Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). (2020): 47 - 51. 10.5152/eurasianjmed.2020.19223
MLA noorozi Karimabad mojgan,NIKNIA Sedigheh,GOLNABADI Mahdieh Bemani,POOR Shirin Fattah,Hajizadeh Mohammadreza,MAHMOODI Mehdi Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). , 2020, ss.47 - 51. 10.5152/eurasianjmed.2020.19223
AMA noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). . 2020; 47 - 51. 10.5152/eurasianjmed.2020.19223
Vancouver noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). . 2020; 47 - 51. 10.5152/eurasianjmed.2020.19223
IEEE noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M "Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro)." , ss.47 - 51, 2020. 10.5152/eurasianjmed.2020.19223
ISNAD noorozi Karimabad, mojgan vd. "Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro)". (2020), 47-51. https://doi.org/10.5152/eurasianjmed.2020.19223
APA noorozi Karimabad m, NIKNIA S, GOLNABADI M, POOR S, Hajizadeh M, MAHMOODI M (2020). Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). Eurasian Journal of Medicine, 52(1), 47 - 51. 10.5152/eurasianjmed.2020.19223
Chicago noorozi Karimabad mojgan,NIKNIA Sedigheh,GOLNABADI Mahdieh Bemani,POOR Shirin Fattah,Hajizadeh Mohammadreza,MAHMOODI Mehdi Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). Eurasian Journal of Medicine 52, no.1 (2020): 47 - 51. 10.5152/eurasianjmed.2020.19223
MLA noorozi Karimabad mojgan,NIKNIA Sedigheh,GOLNABADI Mahdieh Bemani,POOR Shirin Fattah,Hajizadeh Mohammadreza,MAHMOODI Mehdi Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). Eurasian Journal of Medicine, vol.52, no.1, 2020, ss.47 - 51. 10.5152/eurasianjmed.2020.19223
AMA noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). Eurasian Journal of Medicine. 2020; 52(1): 47 - 51. 10.5152/eurasianjmed.2020.19223
Vancouver noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro). Eurasian Journal of Medicine. 2020; 52(1): 47 - 51. 10.5152/eurasianjmed.2020.19223
IEEE noorozi Karimabad m,NIKNIA S,GOLNABADI M,POOR S,Hajizadeh M,MAHMOODI M "Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro)." Eurasian Journal of Medicine, 52, ss.47 - 51, 2020. 10.5152/eurasianjmed.2020.19223
ISNAD noorozi Karimabad, mojgan vd. "Effect of Citrullus colocynthis Extract on Glycated Hemoglobin Formation (In Vitro)". Eurasian Journal of Medicine 52/1 (2020), 47-51. https://doi.org/10.5152/eurasianjmed.2020.19223