The agricultural sector is one of the most dangerous in many countries, including developed countries. Accidents in agricultural machinery and exposure to pesticides and other chemicals are the two main causes of death, injury and disease in the sector. In order to determine the works to be carried out in order to reduce the accidents, injuries and diseases related to agricultural machines in general by using agricultural machines and especially chemical applications, the situation of farmers in terms of usage habits should be analyzed. In this study, it was aimed to investigate the occupational safety problems that occur during the use of plant protection machines which are used extensively in Tokat Province and to determine the degree of compliance with the occupational health and safety rules of the farmers using these machines. For this purpose, a questionnaire was conducted through face to face interviews with farmers using plant protection machines in Zile, Artova, Erbaa and Niksar districts in Tokat. The obtained data were analyzed statistically in SPSS package program and the findings were presented.