KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ

Oral, Alihan; ŞAHİN, TOLGA

KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ

Tolga ŞAHİN, (DEMİROĞLU BİLİM ÜNİVERSİTESİ/TIP FAKÜLTESİ/DAHİLİ TIP BİLİMLERİ BÖLÜMÜ/İÇ HASTALIKLARI ANABİLİM DALI)

Alihan ORAL (DEMİROĞLU BİLİM ÜNİVERSİTESİ/TIP FAKÜLTESİ/DAHİLİ TIP BİLİMLERİ BÖLÜMÜ/İÇ HASTALIKLARI ANABİLİM DALI)

Namık Kemal Tıp Dergisi

4 0

Yıl: 2019 Cilt: 7 Sayı: 3 Sayfa Aralığı: 172 - 179 Metin Dili: Türkçe İndeks Tarihi: 25-06-2020

KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ

Öz:

Amaç:Hepatosellüler karsinom (HCC), dünya çapında kanser kaynaklı ölümlerin ikinci en sık nedenidir. Bu nedenle, HCC’de erken tanı çok önemlidir. Bu çalışmanın amacı, sirozlu hastalarda HCC gelişiminde albumin-bilirubin indeksi (ALBI) ve Platelet- albumin-bilirubin indeksinin (PALBI) prediktivitelerinin değerlendirilmesidir.Materyal ve Metot:Çalışmaya 2004-2019 yılları arasında Demiroğlu Bilim Üniversitesi'ne başvuran kronik hepatit B ve kronik hepatit B + D ‘ ye bağlı karaciğer sirozlu 331 hasta dahil edildi. Hastalar HCC olan ve HCC olmayan olmak üzere iki ana gruba ayrıldı. Hastaların demografik verileri, vücut kitle indeksleri (VKİ), Child ve MELD skorları ve laboratuvar bulguları gruplar için ayrı ayrı kaydedildi ve analiz edildi. Her iki grup için ortalama ALBI ve PALBI değerleri hesaplandı. ALBI, PALBI ve HCC arasındaki ilişkilerdeğerlendirildi.Bulgular:Hastaların yaş ortalaması 51.3 ± 9.18, ortalama BKİ30.04 ± 11.65 idi. HCC grubu 115 hastadan ve HCC olmayan siroz grubu 216 hastadan oluşmaktaydı. Ortalama ALBI ve PALBI skor değerleri, HCC grubunda HCC olmayan siroz grubuna göre anlamlı derecede düşüktü (p <0,001). Eğri altındaki değerler ALBI için 0.775 ve PALBI için 0.733idi.Sonuç:Her ne kadar ALBI ve PALBI, HCC' de sağkalım ve prognozu tahmin etmek için geliştirilse de, çalışmamızda ALBI ve PALBI' nin sirozda HCC gelişiminin tahmininde de yararlı belirleyiciler olabileceği sonucuna varıldı.

Anahtar Kelime:

The Predictive Value of ALBI and P-ALBI Scores in The Prediction of Hepatocellular Carcinoma in Chronic Hepatitis B and Chronic Hepatitis B+D Induced Cirrhosis

Öz:

Aim:Hepatocellular carcinoma (HCC) is the second most common cause of cancer related deaths worldwide. Therefore, early diagnosis is too important for HCC. The aim of this study was to evaluate the predictive value of albumin-bilirubin index (ALBI) and platelet-albumin-bilirubin index (PALBI) on the development of HCC in patients withcirrhosis. Materials and Methods:331 patients with liver cirrhosis due to chronic hepatitis B and chronic hepatitis B + D who were admitted to Demiroğlu Bilim University between 2004-2019 were included in the study. The patients were divided into two main groups, with and without HCC. Demographic data, body mass index (BMI), Child and MELD scores and laboratory findings of the patients were recorded and analyzed separately for the groups. Mean ALBI and PALBI values were calculated for both groups. The relationships between ALBI, PALBI and HCC wereevaluated. Results:The mean age of the patients was 51.3 ± 9.18 and, the mean BMI was 30.04 ± 11.65. The HCC group consisted of 115 patients and the non-HCC cirrhosis group consisted of 216 patients. Mean ALBI and PALBI score values were significantly lower in HCC group than in non-HCC cirrhosis group (p<0,001). Area under curve values (AUC) were calculated 0.775 for the ALBI and 0.733 for thePALBI. Conclusion:Although ALBI and PALBI have been developed to predict the survival and prognosis of HCC, we concluded that ALBI and PALBI may also be useful predictors of HCC development in cirrhosis.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ŞAHİN T, Oral A (2019). KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. , 172 - 179.
Chicago	ŞAHİN TOLGA,Oral Alihan KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. (2019): 172 - 179.
MLA	ŞAHİN TOLGA,Oral Alihan KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. , 2019, ss.172 - 179.
AMA	ŞAHİN T,Oral A KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. . 2019; 172 - 179.
Vancouver	ŞAHİN T,Oral A KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. . 2019; 172 - 179.
IEEE	ŞAHİN T,Oral A "KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ." , ss.172 - 179, 2019.
ISNAD	ŞAHİN, TOLGA - Oral, Alihan. "KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ". (2019), 172-179.

APA	ŞAHİN T, Oral A (2019). KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. Namık Kemal Tıp Dergisi, 7(3), 172 - 179.
Chicago	ŞAHİN TOLGA,Oral Alihan KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. Namık Kemal Tıp Dergisi 7, no.3 (2019): 172 - 179.
MLA	ŞAHİN TOLGA,Oral Alihan KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. Namık Kemal Tıp Dergisi, vol.7, no.3, 2019, ss.172 - 179.
AMA	ŞAHİN T,Oral A KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. Namık Kemal Tıp Dergisi. 2019; 7(3): 172 - 179.
Vancouver	ŞAHİN T,Oral A KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ. Namık Kemal Tıp Dergisi. 2019; 7(3): 172 - 179.
IEEE	ŞAHİN T,Oral A "KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ." Namık Kemal Tıp Dergisi, 7, ss.172 - 179, 2019.
ISNAD	ŞAHİN, TOLGA - Oral, Alihan. "KRONİK HEPATİT B VE B+D KAYNAKLI SİROZDA, HEPATOSELÜLER KARSİNOM GELİŞİMİNİN ÖNGÖRÜLMESİNDE ALBI VE PALBI SKORLAMALARININ PREDİKTİF DEĞERİ". Namık Kemal Tıp Dergisi 7/3 (2019), 172-179.