YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ
Yıl: 2019 Cilt: 7 Sayı: 3 Sayfa Aralığı: 265 - 270 Metin Dili: Türkçe İndeks Tarihi: 26-06-2020
YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ
Öz: Amaç:Günümüzde hipertansiyon (HT) gelişiminde ürik asit (ÜA) yüksekliğinin etkisi olduğunu bildirir çalışmalar mevcut iken dipper, non-dipper HT ile hiperürisemi ve ÜA klirensi arasındaki ilişki net değildir. Biz çalışmamızda; yeni tanı hipertansif hastalarda dipper, non-dipper HT’un, ÜA düzeyi ve klirensi ile ilişkisini değerlendirmeyi amaçladık.Materyal ve Metot:Çalışmamıza hastanemiz İç Hastalıkları ve Nefroloji kliniğinde takipli 59 yeni tanı primer HT hastası ve 24 sağlıklı birey dahil edildi. ÜA klirensi, 24-s idrarda sodyum, 24 saatlik ambulatuar KB ölçümü (24-s AKBM) ve ofis kan basıncı (KB) ölçümü yapıldı. Biyokimyasal parametreler için kan örneği alındı.Bulgular:Çalışmaya 59 HT hastası ile, 24 sağlıklı birey alındı. HT hasta grubunun korelasyon analizinde ÜA düzeyi ile kreatinin düzeyi arasında pozitif korelasyon(r=0.509) (p<0.01), ÜA klirensi ile ise negatif korelasyon(r=-0.494) (p<0.01) saptanmıştır. HT hastaların % 44.1’i non-dipper idi. Dipper ve non dipper hastaların demografik ve laboratuvar parametrelerinin karşılaştırılmasında anlamlı fark saptanmadı.Sonuç:Sonuç olarak yeni tanı HT hastalarında dipper, non-dipper hipertansiflerde ÜA düzeyi ve ÜA klirensini değerlendirdiğimiz çalışmamızda, HT hastalarında ve non-dipper HT hastalarında ÜA düzeyinde anlamlı yükseklik saptamaz iken ÜA klerensinin KB yüksekliği ile pozitif ilişkili olduğunuz saptadık.
Anahtar Kelime: The Relation Between Dipper, Non-dipper Hypertension and Uric Acid Level and Clearance in Newly Diagnosed Hypertensive Patients
Öz: Aim:While there are some studies reporting that higher levels of uric acid (UA) has an effect on the development of hypertension (HT), the relation between dipper, non-dipper HT and hyperuricemia and UA clearance is not clear. In our study;Weaimed to evaluate the relationship between dipper, non-dipper HT and UA level and clearance in newly diagnosed HTpatients. Materials and Methods:59 patients with diagnosed HT and 24 healthy individuals who were followed-up in departments of Internal Medicine and Nephrology, were included into the study. UA clearance and sodium in 24 hour urine were analyzed. Office blood pressure (BP) and 24-hour ambulatory blood pressure (24-h ABPM) were measured. Blood sample was obtained for biochemical analysis. Results:59 newly diagnosed HT patients and 24 healthy individuals were included into the study. The correlation analysis of the hypertensive patient group revealed a positive correlation between the UA and creatinine levels (r = 0.509) (p <0.01) and a negative correlation between UA level and UA clearance (r = - 0.494) (p <0.01). Non-dipper cases consisted of 44.1% of the HT patients. There was no statistically significant difference among the demographic and laboratory parameters between dipper and non- dipper patients. Conclusion:In this study where UA level and clearance in dipper, non-dipper hypertensive cases of newly diagnosed hypertension are evaluated; UA clearance was found to be positively correlated with higher BP where as the level of UA was not significantly elevated in hypertension cases and non-dipper hypertension patients.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kara S (2019). YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. , 265 - 270. |
| Chicago | Kara Sonat Pınar YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. (2019): 265 - 270. |
| MLA | Kara Sonat Pınar YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. , 2019, ss.265 - 270. |
| AMA | Kara S YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. . 2019; 265 - 270. |
| Vancouver | Kara S YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. . 2019; 265 - 270. |
| IEEE | Kara S "YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ." , ss.265 - 270, 2019. |
| ISNAD | Kara, Sonat Pınar. "YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ". (2019), 265-270. |
| APA | Kara S (2019). YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. Namık Kemal Tıp Dergisi, 7(3), 265 - 270. |
| Chicago | Kara Sonat Pınar YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. Namık Kemal Tıp Dergisi 7, no.3 (2019): 265 - 270. |
| MLA | Kara Sonat Pınar YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. Namık Kemal Tıp Dergisi, vol.7, no.3, 2019, ss.265 - 270. |
| AMA | Kara S YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. Namık Kemal Tıp Dergisi. 2019; 7(3): 265 - 270. |
| Vancouver | Kara S YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ. Namık Kemal Tıp Dergisi. 2019; 7(3): 265 - 270. |
| IEEE | Kara S "YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ." Namık Kemal Tıp Dergisi, 7, ss.265 - 270, 2019. |
| ISNAD | Kara, Sonat Pınar. "YENİ TANI HİPERTANSİF HASTALARDA DİPPER, NON-DİPPER HİPERTANSİYONUN ÜRİK ASİT DÜZEYİ VE KLİRENSİ İLE İLİŞKİSİ". Namık Kemal Tıp Dergisi 7/3 (2019), 265-270. |
