Yıl: 2019 Cilt: 36 Sayı: 1 Sayfa Aralığı: 38 - 43 Metin Dili: İngilizce DOI: 10.5152/NSN.2019.11221 İndeks Tarihi: 07-07-2020

Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients

Öz:
Objective: To investigate the relationship between diaphragm motor evoked potential (Dia-MEP) with swallowing, respiratory function and survive in amyotrophic lateral sclerosis (ALS) patients.Methods: Twenty-three ALS patients and 15 healthy subjects were included in the study. Pulmonary function tests were per-formed using forced vital capacity and maximal sniff nasal pressure. Swallowing functions of patients were examined using the dysphagia limit. Transcranial magnetic stimulation (TMS) was applied in ALS patients and healthy subjects. Bilateral cortical and spinal motor evoked potential (MEP) of hemidiaphragm and abductor pollicis brevis (APB) muscles were recorded. Latencies and amplitudes of cortical and spinal MEPs and central motor conduction time (CMCT) were measured.Results: In the ALS group, obtaining rates of cortical MEP from APB and diaphragm muscles were statistically significantly lower than the healthy group. Obtaining rates of cortical diaphragm MEP (Dia-Cx-MEP) were lower in patients with dysphagia and respiratory dysfunction and patients who died but the difference was statistically significant for only patients with respiratory dysfunction. There were no significant difference between amplitudes and latencies of Dia-Cx-MEPl and spinal diaphragm MEP (Dia-Sp-MEP) in patients with and without dysphagia or respiratory dysfunction and patients who died or survived.Conclusion: There were no significant correlations between the Dia-Cx-MEP and Dia-Sp-MEP latency values and the CMCT values of Dia-MEP and the respiratory measures. In ALS patients, the disappearance of Dia-Cx-MEP in spite of the Dia-Sp-MEP can reflect the deterioration of the respiratory pathway from motor cortex.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Kiernan MC, Vucic S, Cheah BC, et al. Amyotrophic lateral sclero-sis. Lancet Neurol 2015; 377: 942-955. [CrossRef]
  • 2. Couratier P, Corcia P, Lautrette G, Nicol M, Preux PM, Marin B. Ep-idemiology of amyotrophic lateral sclerosis: A review of litera-ture. Rev Neurol (Paris) 2016; 172: 37-45. [CrossRef]
  • 3. Prell T, Ringer TM, Wullenkord K, et al. Assessment of pulmonary function in amyotrophic lateral sclerosis: when can polygraphy help evaluate the need for non-invasive ventilation?J Neurol Neurosurg Psychiatry 2016; 87:1022-1026. [CrossRef] 4. Paris G, Martinaud O, Petit A, et al. Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life. J Oral Rehabil 2013; 40: 199-204. [CrossRef]
  • 5. Kaufmann P, Levy G, Thompson JL, et al. The ALSFRSr predicts survival time in an ALS clinic population. Neurology 2005; 64: 38-43. [CrossRef]
  • 6. Kollewe K, Mauss U, Krampfl K, Petri S, Dengler R, Mohammadi B. ALSFRS-R score and its ratio: a useful predictor for ALS-progres-sion. J Neurol Sci 2008; 275: 69-73. [CrossRef]
  • 7. Velasco R, Salachas F, Munerati E, et al. Nocturnal oxymetry in patients with amyotrophic lateral sclerosis: role in predicting survival. Rev Neurol (Paris) 2002; 158: 575-578.
  • 8. Vucic S, Ziemann U, Eisen A, Hallett M, Kiernan MC. Transcranial magnetic stimulation and amyotrophic lateral sclerosis: patho-physiological insights. J Neurol Neurosurg Psychiatry 2013; 84: 1161-1170. [CrossRef]
  • 9. Menon P, Geevasinga N, Yiannikas C, Howells J, Kiernan MC, Vucic S. Sensitivity and specificity of threshold tracking transcranial mag-netic stimulation for diagnosis of amyotrophic lateral sclerosis: a prospective study. Lancet Neurol 2015; 14: 478-484. [CrossRef]
  • 10. Floyd AG, Yu QP, Piboolnurak P, et al. Transcranial magnetic stim-ulation in ALS: utility of central motor conduction tests. Neurol-ogy 2009; 72: 498-504. [CrossRef]
  • 11. Miscio G, Pisano F, Mora G, Mazzini L. Motor neuron disease: use-fulness of transcranial magnetic stimulation in improving the di-agnosis. Clin Neurophysiol 1999; 110: 975-981. [CrossRef]
  • 12. Schulte-Mattler WJ, Müller T, Zierz S. Transcranial magnetic stim-ulation compared with upper motor neuron signs in patients with amyotrophic lateral sclerosis. J Neurol Sci 1999; 170: 51-56. [CrossRef]
  • 13. Kaufmann P, Pullman S, Shungu DC, et al. Objective tests for up-per motor neuron involvement in amyotrophic lateral sclerosis (ALS). Neurology 2004; 62: 1753-1757. [CrossRef]
  • 14. Vucic S, Cheah BC, Yiannikas C, Kiernan MC. Cortical excitabil-ity distinguishes ALS from mimic disorders. Clin Neurophysiol 2011; 122: 1860-1866. [CrossRef]
  • 15. de Carvalho M, Turkman A, Swash M. Motor responses evoked by transcranial magnetic stimulation and peripheral nerve stim-ulation in the ulnar innervation in amyotrophic lateral sclerosis: the effect of upper and lower motor neuron lesion. J Neurol Sci 2003; 210: 83-90. [CrossRef]
  • 16. Lagueny A, Arnaud A, Le Masson G, Burbaud P, Deliac P, Marthan R. Study of central and peripheral conductions to the diaphragm in 22 patients with definite multiple sclerosis. Electromyogr Clin Neurophysiol 1998; 38: 333-342.
  • 17. Miscio G, Guastamacchia G, Priano L, Baudo S, Mauro A. Are the neurophysiological techniques useful for the diag-nosis of dia-phragmatic impairment in multiple sclerosis (MS)? Clin Neuro-physiol 2003; 114: 147-153. [CrossRef]
  • 18. Similowski T, Catala M, Rancurel G, Derenne JP. Impairment of central motor conduction to the diaphragm in stroke. Am J Re-spir Crit Care Med 1996; 154: 436-441. [CrossRef]
  • 19. Zifko U, Chen R, Remtulla H, Hahn A, Koopman W, Bolton CF. Respiratory electrophysiological studies in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry 1996; 60: 191-194. [CrossRef]
  • 20. Zifko UA, Hahn AF, Remtulla H, George CF, Wihlidal W, Bolton CF. Central and peripheral respiratory electrophys-iological studies in myotonic dystrophy. Brain 1996; 119: 1911-1922. [CrossRef]
  • 21. Miscio G, Gukov B, Pisano F, et al. The cortico-diaphragmatic pathway involvement in amyotrophic lateral sclerosis: neuro-physiological, respiratory and clinical considerations. J Neurol Sci 2006; 251: 10-16. [CrossRef]
  • 22. Shimizu T, Komori T, Kugio Y, Fujimaki Y, Oyanagi K, Hayashi H. Electrophysiological assessment of corti-corespiratory pathway function in amyotrophic lateral sclerosis. AmyotropLateral Scler 2010; 11: 57-62. [CrossRef]
  • 23. Erdem NS, Karaali K, Ünal A, Kızılay F, Öğüş C, Uysal H. The inter-action between breathing and swallowing in amyo-trophic lat-eral sclerosis. Acta Neurolog Belg 2016; 116: 549-556 . [CrossRef]
  • 24. Pinto S, Turkman A, Pinto A, Swash M, de Carvalho M. Predicting respiratory insufficiency in amyotrophic lateral scle-rosis: the role of phrenic nerve studies. Clin Neurophysiol 2009; 120: 941-946. [CrossRef]
  • 25. Pinto S, Pinto A, de Carvalho M. Phrenic nerve studies predict survival in amyotrophic lateral sclerosis.Clin Neurophysiol 2012; 123: 2454-2459. [CrossRef]
  • 26. Jenkins JA, Sakamari S, Katz JS, et al. Phrenic nerve conduction studies as a biomarker of respiratory insufficiency in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 2016; 17: 213-220. [CrossRef]
  • 27. Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Dis-eases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Oth-er Motor Neuron Disord 2000; 1: 293-299. [CrossRef]
  • 28. Kleyweg RP, van der Meché FG, Schmitz PI. Interobserver agreement in the assessment of muscle strength and func-tional abilities in Guillain-Barré syndrome. Muscle Nerve 1991; 14: 1103- 1119. [CrossRef]
  • 29. Cedarbaum JM, Stambler N, Malta E, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci 1999; 169: 13-21. [CrossRef]
  • 30. Miller JM, Moxham J, Green M. The maximal sniff in the assessment of diaphragm function in man. Clin Sci (Lond) 1985; 69: 91-96. [CrossRef]
  • 31. Uldry C, Fitting JW. Maximal values of sniff nasal inspiratory pressure in healthy subjects. Thorax 1995; 50: 371-375. [CrossRef]
  • 32. Ertekin C, Aydogdu I, Yüceyar N, Kiylioglu N, Tarlaci S, Uludag B. Pathophysiological mechanisms of oropharyngeal dysphagia in amyotrophic lateral sclerosis. Brain 2000; 123: 125-140. [CrossRef]
  • 33. Ertekin C, Aydoğdu I, Yüceyar N. Piecemeal deglutition and dysphagia limit in normal subjects and in patients with swallowing disorders. J Neurol Neurosurg Psychiatry 1996; 61: 491-496. [CrossRef]
  • 34. Huynh W, Simon NG, Grosskreutz J, Turner MR, Vucic S, Kiernan MC. Assessment of the upper motor neuron in am-yotrophic lateral sclerosis. Clin Neurophysiol 2016; 127: 2643-2660. [CrossRef]
  • 35. Uysal H, Kızılay F, Ünal A, Güngör HA, Ertekin C. The interaction between breathing and swallowing in healthy in-dividuals. J Electromyogr Kinesiol 2013; 23: 659-663. [CrossRef]
APA ŞİMŞEK ERDEM N, İLGEN USLU F, Bozkurt S, UYSAL H (2019). Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. , 38 - 43. 10.5152/NSN.2019.11221
Chicago ŞİMŞEK ERDEM NAZAN,İLGEN USLU Ferda,Bozkurt Selen,UYSAL Hilmi Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. (2019): 38 - 43. 10.5152/NSN.2019.11221
MLA ŞİMŞEK ERDEM NAZAN,İLGEN USLU Ferda,Bozkurt Selen,UYSAL Hilmi Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. , 2019, ss.38 - 43. 10.5152/NSN.2019.11221
AMA ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. . 2019; 38 - 43. 10.5152/NSN.2019.11221
Vancouver ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. . 2019; 38 - 43. 10.5152/NSN.2019.11221
IEEE ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H "Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients." , ss.38 - 43, 2019. 10.5152/NSN.2019.11221
ISNAD ŞİMŞEK ERDEM, NAZAN vd. "Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients". (2019), 38-43. https://doi.org/10.5152/NSN.2019.11221
APA ŞİMŞEK ERDEM N, İLGEN USLU F, Bozkurt S, UYSAL H (2019). Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. Neurological sciences and neurophysiology (Online), 36(1), 38 - 43. 10.5152/NSN.2019.11221
Chicago ŞİMŞEK ERDEM NAZAN,İLGEN USLU Ferda,Bozkurt Selen,UYSAL Hilmi Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. Neurological sciences and neurophysiology (Online) 36, no.1 (2019): 38 - 43. 10.5152/NSN.2019.11221
MLA ŞİMŞEK ERDEM NAZAN,İLGEN USLU Ferda,Bozkurt Selen,UYSAL Hilmi Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. Neurological sciences and neurophysiology (Online), vol.36, no.1, 2019, ss.38 - 43. 10.5152/NSN.2019.11221
AMA ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. Neurological sciences and neurophysiology (Online). 2019; 36(1): 38 - 43. 10.5152/NSN.2019.11221
Vancouver ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients. Neurological sciences and neurophysiology (Online). 2019; 36(1): 38 - 43. 10.5152/NSN.2019.11221
IEEE ŞİMŞEK ERDEM N,İLGEN USLU F,Bozkurt S,UYSAL H "Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients." Neurological sciences and neurophysiology (Online), 36, ss.38 - 43, 2019. 10.5152/NSN.2019.11221
ISNAD ŞİMŞEK ERDEM, NAZAN vd. "Relationship between diaphragm MEP and swallowing, respiratory function and survive in ALS patients". Neurological sciences and neurophysiology (Online) 36/1 (2019), 38-43. https://doi.org/10.5152/NSN.2019.11221