The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults
Yıl: 2019 Cilt: 25 Sayı: 2 Sayfa Aralığı: 111 - 117 Metin Dili: İngilizce DOI: 10.5505/tjtes.2018.63439 İndeks Tarihi: 10-06-2020
The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults
Öz: BACKGROUND: The primary aim of this study was to compare the effects of a small-dose infusion of 2 antioxidant agents, ketamineand lidocaine, on ischemia-reperfusion injury (IRI) in patients undergoing elective lower limb surgery. Ischemia-modified albumin (IMA),lactate, and blood gas levels were all measured and assessed.METHODS: A total of 100 patients who underwent lower extremity surgery were randomized into 3 groups. After spinal anesthesia, the ketamine group (Group K, n=33) was given a ketamine infusion, a lidocaine infusion was administered to the lidocaine group(Group L, n=33), and in the control group (Group C), 0.9% a sodium chloride infusion was performed. Blood samples were obtainedfor IMA analysis before anesthetic administration (baseline), at 30 minutes of tourniquet inflation (ischemia), and 15 minutes aftertourniquet deflation (reperfusion). Arterial blood gas measurements were determined before anesthetic administration and 15 minutes after tourniquet deflation.RESULTS: The lactate and IMA levels at reperfusion were significantly lower in both the ketamine group and the lidocaine groupwhen compared with the control group.CONCLUSION: The administration of both ketamine and lidocaine infusions significantly decreased skeletal muscle IRI-related highlactate and IMA levels. These results suggest the possibility of the clinical application of ketamine or lidocaine infusions in cases ofskeletal muscle-related IRI.
Anahtar Kelime: Ketamin ve lidokainin erişkinlerde turnike kaynaklı iskemi-reperfüzyon hasarından sonra serbest radikal üretimi üzerine etkileri
Öz: AMAÇ: Amacımız, elektif alt ekstremite cerrahisi uygulanan hastalarda iki antioksidan ajan, ketamin ve lidokainin küçük doz infüzyonunun iskemireperfüzyon hasarı (IRI) üzerine olan etkisini karşılaştırmaktır. Bu amaçla iskemi modifiye albümin (IMA), laktat ve kan gazı seviyeleri ölçüldü. GEREÇ VE YÖNTEM: Alt ekstremite cerrahisi uygulanan 100 hasta randomize olarak üç gruba ayrıldı. Spinal anesteziden sonra ketamin grubunda (Grup K, n=33), ketamin infüzyonu, lidokain grubunda (Grup L, n=33), lidokain infüzyonu, kontrol grubunda (Grup C) %0.9 NaCl infüzyonu uygulandı. IMA analizi için kan örnekleri anestezik uygulamadan önce (bazal değer), 30 dakika turnike enflasyonunda (iskemi) ve turnike deflasyonundan 15 dakika sonra (reperfüzyon) elde edildi. Arteriyel kan gazı ölçümleri anestezi uygulaması öncesi ve turnike deflasyonundan 15 dakika sonra belirlendi. BULGULAR: Reperfüzyonda laktat ve IMA düzeyleri kontrol grubu ile karşılaştırıldığında hem ketamin grubunda hem de lidokain grubunda anlamlı olarak düşüktü. TARTIŞMA: Hem ketamin hem de lidokain infüzyonunun uygulanması, iskelet kası IRI ile ilişkili yüksek laktat ve yüksek IMA düzeylerini anlamlı olarak azaltmıştır. Bu sonuçlar, iskelet kası ile ilişkili IRI’da, ketamin veya lidokain infüzyonlarının klinik uygulanabilme olasılığını düşündürmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | PEKER K, ÖKESLİ S, KIYICI A, DEYİŞLİ C (2019). The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. , 111 - 117. 10.5505/tjtes.2018.63439 |
| Chicago | PEKER Kevser,ÖKESLİ Selmin,KIYICI Aysel,DEYİŞLİ Cemile The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. (2019): 111 - 117. 10.5505/tjtes.2018.63439 |
| MLA | PEKER Kevser,ÖKESLİ Selmin,KIYICI Aysel,DEYİŞLİ Cemile The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. , 2019, ss.111 - 117. 10.5505/tjtes.2018.63439 |
| AMA | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. . 2019; 111 - 117. 10.5505/tjtes.2018.63439 |
| Vancouver | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. . 2019; 111 - 117. 10.5505/tjtes.2018.63439 |
| IEEE | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C "The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults." , ss.111 - 117, 2019. 10.5505/tjtes.2018.63439 |
| ISNAD | PEKER, Kevser vd. "The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults". (2019), 111-117. https://doi.org/10.5505/tjtes.2018.63439 |
| APA | PEKER K, ÖKESLİ S, KIYICI A, DEYİŞLİ C (2019). The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. Ulusal Travma ve Acil Cerrahi Dergisi, 25(2), 111 - 117. 10.5505/tjtes.2018.63439 |
| Chicago | PEKER Kevser,ÖKESLİ Selmin,KIYICI Aysel,DEYİŞLİ Cemile The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. Ulusal Travma ve Acil Cerrahi Dergisi 25, no.2 (2019): 111 - 117. 10.5505/tjtes.2018.63439 |
| MLA | PEKER Kevser,ÖKESLİ Selmin,KIYICI Aysel,DEYİŞLİ Cemile The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. Ulusal Travma ve Acil Cerrahi Dergisi, vol.25, no.2, 2019, ss.111 - 117. 10.5505/tjtes.2018.63439 |
| AMA | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(2): 111 - 117. 10.5505/tjtes.2018.63439 |
| Vancouver | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(2): 111 - 117. 10.5505/tjtes.2018.63439 |
| IEEE | PEKER K,ÖKESLİ S,KIYICI A,DEYİŞLİ C "The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults." Ulusal Travma ve Acil Cerrahi Dergisi, 25, ss.111 - 117, 2019. 10.5505/tjtes.2018.63439 |
| ISNAD | PEKER, Kevser vd. "The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults". Ulusal Travma ve Acil Cerrahi Dergisi 25/2 (2019), 111-117. https://doi.org/10.5505/tjtes.2018.63439 |
