The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia
Yıl: 2019 Cilt: 25 Sayı: 3 Sayfa Aralığı: 205 - 212 Metin Dili: İngilizce DOI: 10.5505/tjtes.2018.49139 İndeks Tarihi: 10-06-2020
The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia
Öz: BACKGROUND: Acute mesenteric ischemia (AMI) is associated with a high mortality rate, yet diagnostic difficulties persist.Although many biomarkers have been investigated for diagnostic purposes, as well as imaging methods, a sufficiently specific and sensitive marker has not been identified. This research was designed to examine whether heparin-binding protein (HBP), which has a rolein the early phase of inflammation, could be useful in the diagnosis of AMI.METHODS: Serum samples obtained from a previously performed rabbit model of AMI were used in the study. HBP, C-reactiveprotein (CRP) and interleukin 6 (IL-6) levels were measured in blood samples obtained at baseline and 1, 3, and 6 hours from subjectsthat were separated into 3 groups: control, sham, and ischemia. The change in each marker over time and comparisons of the groupswere evaluated statistically.RESULTS: A significant difference was not detected at the first hour in any of the studied markers. At the third hour, the CRP andIL-6 levels in the ischemia group indicated a significant increase in comparison with the control and sham groups (p<0.001). The HBPvalues showed a significant increase at the sixth hour in the ischemia group in comparison with the others (p<0.001).CONCLUSION: The HBP level demonstrated a slower increase in a rabbit model of AMI compared with CRP and IL-6. However,it still has the potential to become an early diagnostic biomarker. Diagnostic sensitivity and specificity should be evaluated in further clinical trials.
Anahtar Kelime: Akut mezenter iskemi tanısında heparin-bağlayıcı proteinin rolü
Öz: AMAÇ: Akut mezenterik iskemi (AMİ), acil servislere sık başvuru nedenlerinden biri değildir. Ancak tanısal zorluklar ve bununla ilişkili yüksek mortalite düzeyleri sürmektedir. Görüntüleme yöntemleri yanı sıra birçok biyokimyasal belirteç tanısal amaçlı araştırılmış olmasına rağmen yeterince özgül ve duyarlı bir belirteç ortaya konamamıştır. Bu çalışmada, enflamasyonun erken safhasında rol oynadığı belirlenen heparin-bağlayıcı proteinin (HBP) AMİ tanısında yararlı olup olamayacağı araştırıldı. GEREÇ VE YÖNTEM: Çalışmada daha önce yapılmış, AMİ’nin bir tavşan modelinden elde edilmiş serum örnekleri kullanıldı. Kontrol, sham ve iskemi grubu olmak üzere üç gruba ayrılan deneklerden 0., 1., 3. ve 6. saatlerde elde edilen kan örneklerinde HBP, C-reaktif protein (CRP) ve interlökin-6 (IL-6) düzeyleri ölçüldü. Herbir belirtecin zamanla değişimi ve biribirleriyle karşılaştırılması istatistiksel olarak değerlendirildi. BULGULAR: Çalışılan belirteçlerin hiçbirinde 1. saatte gruplar arasında anlamlı bir fark belirlenmedi. Üçüncü saatten itibaren iskemi grubunda CRP ve IL-6 düzeyleri, kontrol ve sham gruplarına göre anlamlı yükselme göstermiştir (p<0.001). HBP değerleri ise 6. saatten itibaren iskemi grubunda diğerlerine göre anlamlı yükselme gösterdi (p<0.001). TARTIŞMA: Heparin-bağlayıcı protein düzeyleri, AMİ’nin tavşan modelinde CRP ve IL-6’ya göre daha geç yükselme gösterdi. Ancak yine de bir erken tanı belirteci olma potansiyel taşımaktadır. Yapılacak klinik çalışmalarla tanısal sensitivite ve spesifisitesinin değerlendirilmesi gerekmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kocak S, Acar T, ERTEKİN B, GÜVEN M, Dundar Z (2019). The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. , 205 - 212. 10.5505/tjtes.2018.49139 |
| Chicago | Kocak Sedat,Acar Tarık,ERTEKİN Birsen,GÜVEN Merve,Dundar Zerrin Defne The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. (2019): 205 - 212. 10.5505/tjtes.2018.49139 |
| MLA | Kocak Sedat,Acar Tarık,ERTEKİN Birsen,GÜVEN Merve,Dundar Zerrin Defne The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. , 2019, ss.205 - 212. 10.5505/tjtes.2018.49139 |
| AMA | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. . 2019; 205 - 212. 10.5505/tjtes.2018.49139 |
| Vancouver | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. . 2019; 205 - 212. 10.5505/tjtes.2018.49139 |
| IEEE | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z "The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia." , ss.205 - 212, 2019. 10.5505/tjtes.2018.49139 |
| ISNAD | Kocak, Sedat vd. "The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia". (2019), 205-212. https://doi.org/10.5505/tjtes.2018.49139 |
| APA | Kocak S, Acar T, ERTEKİN B, GÜVEN M, Dundar Z (2019). The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. Ulusal Travma ve Acil Cerrahi Dergisi, 25(3), 205 - 212. 10.5505/tjtes.2018.49139 |
| Chicago | Kocak Sedat,Acar Tarık,ERTEKİN Birsen,GÜVEN Merve,Dundar Zerrin Defne The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. Ulusal Travma ve Acil Cerrahi Dergisi 25, no.3 (2019): 205 - 212. 10.5505/tjtes.2018.49139 |
| MLA | Kocak Sedat,Acar Tarık,ERTEKİN Birsen,GÜVEN Merve,Dundar Zerrin Defne The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. Ulusal Travma ve Acil Cerrahi Dergisi, vol.25, no.3, 2019, ss.205 - 212. 10.5505/tjtes.2018.49139 |
| AMA | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(3): 205 - 212. 10.5505/tjtes.2018.49139 |
| Vancouver | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(3): 205 - 212. 10.5505/tjtes.2018.49139 |
| IEEE | Kocak S,Acar T,ERTEKİN B,GÜVEN M,Dundar Z "The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia." Ulusal Travma ve Acil Cerrahi Dergisi, 25, ss.205 - 212, 2019. 10.5505/tjtes.2018.49139 |
| ISNAD | Kocak, Sedat vd. "The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia". Ulusal Travma ve Acil Cerrahi Dergisi 25/3 (2019), 205-212. https://doi.org/10.5505/tjtes.2018.49139 |
