Ceren ŞEN TANRIKULU
(Sağlık Bilimleri Üniversitesi, Konya Eğitim ve Araştırma Hastanesi, Acil Tıp Anabilim Dalı, Konya, Türkiye)
YUSUF TANRIKULU
(KTO KARATAY ÜNİVERSİTESİ/TIP FAKÜLTESİ/CERRAHİ TIP BİLİMLERİ BÖLÜMÜ/GENEL CERRAHİ ANABİLİM DALI)
FAHRİYE KILINÇ
(Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Konya, Türkiye)
BURAK BAHADIR
(Bülent Ecevit Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)
MURAT CAN
(Bülent Ecevit Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Zonguldak, Türkiye)
FÜRÜZAN KÖKTÜRK
(Bülent Ecevit Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Zonguldak, Türkiye)
AYŞE KEFELİ
(Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Tokat, Türkiye)
Yıl: 2019Cilt: 25Sayı: 4ISSN: 1306-696X / 1307-7945Sayfa Aralığı: 317 - 323İngilizce

135 0
The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study
BACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of strictureprogression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protectiveand anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns.METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groupsreceived sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3topical MB, and group 4 topical and systemic MB.RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-α (TNF-α) levels between the groups.The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). Thehistopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05).CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage.
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