Yıl: 2019 Cilt: 25 Sayı: 4 Sayfa Aralığı: 317 - 323 Metin Dili: İngilizce DOI: 10.5505/tjtes.2018.58506 İndeks Tarihi: 12-06-2020

The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study

Öz:
BACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of strictureprogression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protectiveand anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns.METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groupsreceived sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3topical MB, and group 4 topical and systemic MB.RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-α (TNF-α) levels between the groups.The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). Thehistopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05).CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage.
Anahtar Kelime:

Korozif özefagus yanıklarında metilen mavisinin koruyucu ve anti-enflamatuvar etkisi: Deneysel çalışma

Öz:
AMAÇ: Gelişmekte olan ülkelerde daha sık görülen ve korozif madde yutulmasına bağlı oluşan özefageal yanıkları kısa dönemde özefagus perforasyonuna ve uzun dönemde darlık oluşmasına neden olmaktadır. Korozif özefagus yanıklarında tedavinin asıl amacı özefagusta darlık oluşumunu önlenmektir. Biz, bu çalışmada korozif özefagus yanıklarının tedavisinde metilen mavisinin (MB) antienflamatuvar ve koruyucu etkisini araştırmayı amaçladık. GEREÇ VE YÖNTEM: Çalışmada 28 sıçan kullanıldı ve sıçanlar rastgele dört eşit gruba ayrıldı; 1. grup (Sham), 2. grup (kontrol), 3. grup (topikal tedavi) ve 4. grup (topikal ve sistemik tedavi). Sham grubu hariç diğer gruplara özefageal yanık oluşturmak için sodyum hidroksit (NaOH) verildi. Ek olarak, ikinci gruba normal salin, 3. gruba topikal metilen mavisi ve 4. gruba topikal ve sistemik metilen mavisi verildi. BULGULAR: Hidroksiprolin seviyeleri her bir tedavi grubunda kontrol grubuna göre daha düşüktü (p=0.005 grup 3’e göre, p=0.00 grup 4’e göre). Tümör nekrozis faktör-α seviyelerine göre gruplar arasında fark yoktu. Tedavi gruplarına ait stenoz indeksleri kontrol grubuna göre daha düşüktü (p=0.016 grup 3’e göre, p=0.015 grup 4’e göre). Histopatolojik hasar skoru kontrol grubu ile karşılaştırıldığında grup 4’te belirgin olarak daha düşüktü (p=0.05). TARTIŞMA: Metilen mavisi korozif özefageal yanıkların neden olduğu doku hasarını tedavi etmede ve özefageal stenozu önlemede etkilidir. Korozif özefageal yanıklardaki komplikasyon oranları yanık esnasında kullanılan metilen mavisi ile azaltılabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ŞEN TANRIKULU C, TANRIKULU Y, KILINÇ F, Bahadir B, CAN M, KÖKTÜRK F, KEFELİ A (2019). The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. , 317 - 323. 10.5505/tjtes.2018.58506
Chicago ŞEN TANRIKULU Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan,KEFELİ Ayşe The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. (2019): 317 - 323. 10.5505/tjtes.2018.58506
MLA ŞEN TANRIKULU Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan,KEFELİ Ayşe The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. , 2019, ss.317 - 323. 10.5505/tjtes.2018.58506
AMA ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. . 2019; 317 - 323. 10.5505/tjtes.2018.58506
Vancouver ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. . 2019; 317 - 323. 10.5505/tjtes.2018.58506
IEEE ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A "The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study." , ss.317 - 323, 2019. 10.5505/tjtes.2018.58506
ISNAD ŞEN TANRIKULU, Ceren vd. "The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study". (2019), 317-323. https://doi.org/10.5505/tjtes.2018.58506
APA ŞEN TANRIKULU C, TANRIKULU Y, KILINÇ F, Bahadir B, CAN M, KÖKTÜRK F, KEFELİ A (2019). The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, 25(4), 317 - 323. 10.5505/tjtes.2018.58506
Chicago ŞEN TANRIKULU Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan,KEFELİ Ayşe The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi 25, no.4 (2019): 317 - 323. 10.5505/tjtes.2018.58506
MLA ŞEN TANRIKULU Ceren,TANRIKULU Yusuf,KILINÇ FAHRİYE,Bahadir Burak,CAN Murat,KÖKTÜRK Fürüzan,KEFELİ Ayşe The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, vol.25, no.4, 2019, ss.317 - 323. 10.5505/tjtes.2018.58506
AMA ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(4): 317 - 323. 10.5505/tjtes.2018.58506
Vancouver ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2019; 25(4): 317 - 323. 10.5505/tjtes.2018.58506
IEEE ŞEN TANRIKULU C,TANRIKULU Y,KILINÇ F,Bahadir B,CAN M,KÖKTÜRK F,KEFELİ A "The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study." Ulusal Travma ve Acil Cerrahi Dergisi, 25, ss.317 - 323, 2019. 10.5505/tjtes.2018.58506
ISNAD ŞEN TANRIKULU, Ceren vd. "The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study". Ulusal Travma ve Acil Cerrahi Dergisi 25/4 (2019), 317-323. https://doi.org/10.5505/tjtes.2018.58506