BACKGROUND: Fournier’s gangrene (FG) is a very rare disease in daily urological practice. Despite medical improvements, mortality in FG is still high. Early diagnosis is very important to reduce additional instrumentations and mortality. In this study, we aimed topresent the characteristics of the patients with Fournier’s gangrene followed in two centers during ten years period.METHODS: The medical records of patients with FG were reviewed retrospectively. The patient characteristics, causative pathogens,laboratory findings and treatment modalities were evaluated.RESULTS: A total of 36 FG cases admitted between January 2008 and February 2018 were included in this study, consisting of 35male patients, and one female patient with a mean age of 59.27±12.91 years. The mean duration of hospital stay was 19±10.44 days.The most common predisposing factor was diabetes mellitus, which was found in 28 patients. Malignancy was detected in three patients; prostate cancer in two patients and chronic lymphoblastic leukemia in one patient. Two patients had liver cirrhosis, and onepatient had Behcet’s disease and psoriasis. The microbiological agent was isolated from a wound culture in nine patients. After urgentsurgical debridement, daily dressing with nitrofurazone (Furacin) was done. Additional debridement was conducted when necessary.Orchiectomy was performed in 10 patients; two of them underwent bilateral orchiectomy. One patient died because of sepsis on theseventh day of hospital admission.CONCLUSION: FG is a life-threatening urological emergency with a high mortality rate. Treatment with broad-spectrum antibioticsand urgent surgery is pivotal for the prevention of mortality