Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
Yıl: 2018 Cilt: 24 Sayı: 5 Sayfa Aralığı: 405 - 411 Metin Dili: İngilizce DOI: 10.5505/tjtes.2018.59280 İndeks Tarihi: 17-09-2020
Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
Öz: BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healingeffect.METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan wasapplied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl,PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized.RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl–chitosan was lower than PDS–chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coatedVicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl–chitosan increasedmore than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS–chitosandecreased more than PDS on the 7th day in vivo (p<0.05).CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro andPDS in vivo was slightly improved.
Anahtar Kelime: Kitosan kaplı ipliklerin anastomoz gücü arttırma üzerine etkisi
Öz: AMAÇ: Yara iyileşmesi etkisiyle, kitosan kaplı ipliklerin bağırsak anastomozu gücü üzerine uygulanabilir olmasını araştırdık. GEREÇ VE YÖNTEM: Vikril ve PDS iplikler %2 kitosanla kaplandı. Laparatomi birinci gruba uygulanırken, kitosan ikici grupta periton boşluğuna uygulandı. Takibinde sırasıyla vikril, PDS, kitosan kaplı vikril ve kitosan kaplı PDS iplikler kolon anastomozunda kullanıldı. Yedinci ve 14. günlerde her gruptan sekiz sıçan sakrifiye edilerek incelemesi yapıldı. BULGULAR: Kitosan ve kontrol grubunun adezyon değeri iplik gruplarına göre anlamlı olarak daha düşük saptandı (p<0.05). Kitosan kaplı vikril grubunun 14. günde vaskülarizasyon değeri, kitosan kaplı PDS iplik grubuna göre anlamlı olarak daha az olduğu belirlendi (p=0.038). Kitosan kaplı vikrilin 14. gücünde, anastomoz vaskülarizasyonu ve fibroblast hücreleri üzerinde vikril ve kitosan kaplı PDS göre etkisi daha düşük bulundu (p<0.05). Kitosan kaplı vikrilin 14. ve yedinci günündeki in vitro mukavemet gücü vikrilden daha yüksek olmasına rağmen (p<0.05), in vivo farklılık görülmedi. The PDS-kitosan’ın mukavemet gücü in vivo yedinci günde, PDS’den daha az olarak saptandı (p<0.05). TARTIŞMA: Kitosan ile kaplama, anastomoz gücünü ve adezyon etkisini hafif oranda in vitro vikril ve in vivo PDS üzerinde arttırdı.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Altinel Y, Chung S, Ozkaya G, Ugras N, ISIK A, Ozturk E, Özgüç H (2018). Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. , 405 - 411. 10.5505/tjtes.2018.59280 |
| Chicago | Altinel Yuksel,Chung Soon Sup,Ozkaya Guven,Ugras Nesrin,ISIK AHMET FATIH,Ozturk Ersin,Özgüç Halil Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. (2018): 405 - 411. 10.5505/tjtes.2018.59280 |
| MLA | Altinel Yuksel,Chung Soon Sup,Ozkaya Guven,Ugras Nesrin,ISIK AHMET FATIH,Ozturk Ersin,Özgüç Halil Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. , 2018, ss.405 - 411. 10.5505/tjtes.2018.59280 |
| AMA | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. . 2018; 405 - 411. 10.5505/tjtes.2018.59280 |
| Vancouver | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. . 2018; 405 - 411. 10.5505/tjtes.2018.59280 |
| IEEE | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H "Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis." , ss.405 - 411, 2018. 10.5505/tjtes.2018.59280 |
| ISNAD | Altinel, Yuksel vd. "Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis". (2018), 405-411. https://doi.org/10.5505/tjtes.2018.59280 |
| APA | Altinel Y, Chung S, Ozkaya G, Ugras N, ISIK A, Ozturk E, Özgüç H (2018). Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. Ulusal Travma ve Acil Cerrahi Dergisi, 24(5), 405 - 411. 10.5505/tjtes.2018.59280 |
| Chicago | Altinel Yuksel,Chung Soon Sup,Ozkaya Guven,Ugras Nesrin,ISIK AHMET FATIH,Ozturk Ersin,Özgüç Halil Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. Ulusal Travma ve Acil Cerrahi Dergisi 24, no.5 (2018): 405 - 411. 10.5505/tjtes.2018.59280 |
| MLA | Altinel Yuksel,Chung Soon Sup,Ozkaya Guven,Ugras Nesrin,ISIK AHMET FATIH,Ozturk Ersin,Özgüç Halil Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. Ulusal Travma ve Acil Cerrahi Dergisi, vol.24, no.5, 2018, ss.405 - 411. 10.5505/tjtes.2018.59280 |
| AMA | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. Ulusal Travma ve Acil Cerrahi Dergisi. 2018; 24(5): 405 - 411. 10.5505/tjtes.2018.59280 |
| Vancouver | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis. Ulusal Travma ve Acil Cerrahi Dergisi. 2018; 24(5): 405 - 411. 10.5505/tjtes.2018.59280 |
| IEEE | Altinel Y,Chung S,Ozkaya G,Ugras N,ISIK A,Ozturk E,Özgüç H "Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis." Ulusal Travma ve Acil Cerrahi Dergisi, 24, ss.405 - 411, 2018. 10.5505/tjtes.2018.59280 |
| ISNAD | Altinel, Yuksel vd. "Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis". Ulusal Travma ve Acil Cerrahi Dergisi 24/5 (2018), 405-411. https://doi.org/10.5505/tjtes.2018.59280 |
