Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”
Yıl: 2020 Cilt: 17 Sayı: 3 Sayfa Aralığı: 249 - 253 Metin Dili: İngilizce DOI: 10.4274/tjps.galenos.2019.38278 İndeks Tarihi: 27-11-2020
Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”
Öz: Objectives: This study was performed to understand the behavior of poorly compressible paracetamol powder using a compaction simulator (CS),equipment that records data during the compaction process. The aim was to investigate the compressibility of paracetamol tablets using a drygranulation (slugging) process, with different formulation compositions.Materials and Methods: Formulations were prepared to observe the effect on compressibility with two different lactose-based fillers, Flowlac®100and Granulac®70, and a binder, Kollidon® K90. In each combination, a total of four formulations were prepared with paracetamol to filler ratiosof 1:1 and 0.8:1. Tablets were produced by single punch (11.28 mm) CS at six different pressures (152, 210, 263, 316, 400, and 452 MPa). Duringcompression, upper punch displacement and force data were produced by the CS equipment. The compressed tablets were tested for hardness,thickness, and weight variation and compared with each other.Results: All formulations reached maximum tensile strength at compaction pressures between 263 and 316 MPa. In the formulations without binder,those containing Granulac®70 had higher tensile strength than those containing Flowlac®100 at both filler ratios. The results obtained indicated thatthe addition of binder to the formulations (F-45-1, F-45-2, F-50-3, and F-50-4) improved the compressibility of paracetamol. Formulation F-45-2,containing Flowlac®100 and binder, showed better compressibility at 2.9 MPa tensile strength. Data from the CS were used to compare Young’smodulus and work of compaction on selected formulations (F-45-1 and F-45-2).Conclusion: The proposed lactose-based filler, Flowlac®100, with low pressure can be successfully applied for improving the compressibility ofparacetamol. An optimum formulation can be designed with smaller amounts of materials using a compaction simulator.
Anahtar Kelime: “Compaction Simulator” Kullanılarak Parasetamolün Basılabilirlik Özelliklerinin İncelenmesi
Öz: Amaç: Bu çalışmada basım sırasında verileri kaydeden “Compaction Simulator (CS)” cihazı kullanılarak sıkışabilirlik özellikleri zayıf olan toz parasetamolün basılabilirlik davranışları incelendi. Çalışmanın amacı, kuru granülasyon (slugging) yöntemi ile hazırlanan farklı formülasyonlardaki parasetamol tabletlerin basılabilirlik özelliklerinin incelenmesidir. Gereç ve Yöntemler: Laktoz bazlı iki değişik dolgu maddesi olarak Flowlac®100 ve Granulac®70 ile bağlayıcı olarak Kollidon®K90 kullanılarak hazırlanan farklı formülasyonların basılabilirliği üzerine bu maddelerin etkisi gözlendi. Her kombinasyon için parasetamol: yardımcı madde oranı 1:1 ve 0.8:1 olan toplam 4 formülasyon hazırlandı. Tabletler tek zımbalı (11,28 mm) CS’de altı farklı basınçta (152, 210, 263, 316, 400, 452 MPa) üretildi. Sıkıştırma sırasında üst zımba ötelemesi ve zımba kuvvet verileri CS cihazı çıktılarıdır. Basılan tabletleride sertlik, kalınlık ve ağırlık sapması testleri yapıldı ve sonuçlar birbirleri ile mukayese edildi. Bulgular: Bütün formülasyonlar en büyük gerilme direncine 263-316 MPa sıkıştırma aralığındaki basınçta ulaştılar. Bağlayıcı olmayan ve aynı oranda dolgu maddesi içeren formülasyonlarda Granulac®70 içerenler, Flowlac®100 içerenlere göre daha yüksek gerilme direnci göstermiştir. Sonuçlara göre, formülasyonlara bağlayıcı ilavesi (F-45-1, F-45-2, F-50-3 ve F-50-4), parasetamolün basılabilirliğini iyileştirmiştir. Flowlac®100 ve bağlayıcı içeren F-45-2 formülasyonu 2,9 MPa basınçta daha iyi bir basılabilirlik göstermiştir. CS verileri belli formülasyonlarda (F-45-1 ve F-45-2) Young modülleri ve basım çalışmaları sonuçlarını karşılaştırmada kullanılmıştır. Sonuç: Parasetamolün düşük basınçta basılabilirliği laktoz bazlı dolgu maddesi olan Flowlac®100 ile başarıyla sağlanabilmiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Ozalp Y, CHUNU J, Jiwa N (2020). Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. , 249 - 253. 10.4274/tjps.galenos.2019.38278 |
Chicago | Ozalp Yildiz,CHUNU Joseph Turemi,Jiwa Nailla Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. (2020): 249 - 253. 10.4274/tjps.galenos.2019.38278 |
MLA | Ozalp Yildiz,CHUNU Joseph Turemi,Jiwa Nailla Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. , 2020, ss.249 - 253. 10.4274/tjps.galenos.2019.38278 |
AMA | Ozalp Y,CHUNU J,Jiwa N Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. . 2020; 249 - 253. 10.4274/tjps.galenos.2019.38278 |
Vancouver | Ozalp Y,CHUNU J,Jiwa N Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. . 2020; 249 - 253. 10.4274/tjps.galenos.2019.38278 |
IEEE | Ozalp Y,CHUNU J,Jiwa N "Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”." , ss.249 - 253, 2020. 10.4274/tjps.galenos.2019.38278 |
ISNAD | Ozalp, Yildiz vd. "Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”". (2020), 249-253. https://doi.org/10.4274/tjps.galenos.2019.38278 |
APA | Ozalp Y, CHUNU J, Jiwa N (2020). Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. Turkish Journal of Pharmaceutical Sciences, 17(3), 249 - 253. 10.4274/tjps.galenos.2019.38278 |
Chicago | Ozalp Yildiz,CHUNU Joseph Turemi,Jiwa Nailla Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. Turkish Journal of Pharmaceutical Sciences 17, no.3 (2020): 249 - 253. 10.4274/tjps.galenos.2019.38278 |
MLA | Ozalp Yildiz,CHUNU Joseph Turemi,Jiwa Nailla Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. Turkish Journal of Pharmaceutical Sciences, vol.17, no.3, 2020, ss.249 - 253. 10.4274/tjps.galenos.2019.38278 |
AMA | Ozalp Y,CHUNU J,Jiwa N Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. Turkish Journal of Pharmaceutical Sciences. 2020; 17(3): 249 - 253. 10.4274/tjps.galenos.2019.38278 |
Vancouver | Ozalp Y,CHUNU J,Jiwa N Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”. Turkish Journal of Pharmaceutical Sciences. 2020; 17(3): 249 - 253. 10.4274/tjps.galenos.2019.38278 |
IEEE | Ozalp Y,CHUNU J,Jiwa N "Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”." Turkish Journal of Pharmaceutical Sciences, 17, ss.249 - 253, 2020. 10.4274/tjps.galenos.2019.38278 |
ISNAD | Ozalp, Yildiz vd. "Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”". Turkish Journal of Pharmaceutical Sciences 17/3 (2020), 249-253. https://doi.org/10.4274/tjps.galenos.2019.38278 |