The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study

GÜNEŞ ŞAHİN, GÜLŞAH; Şahin Ergül, Serap; MUHTAROĞLU, Sebahattin; Gündoğan, Kürşat; Sungur, Murat; dogan, ender; Ziegler, Thomas; Akbudak, İsmail hakkı; OZER, NURHAYAT TUGRA; Güven, Muhammet

doi:10.3906/sag-1911-165

The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study

Kürşat GÜNDOĞAN, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Yoğun Bakım Bilim Dalı, Kayseri, Türkiye)

Ender DOĞAN, (Erciyes Üniversitesi, Tıp Fakültesi, Kayseri, Türkiye)

Nurhayat ÖZER, (Erciyes Üniversitesi, Sağlık Bilimleri Enstitüsü, Klinik Beslenme Anabilim Dalı, Kayseri, Türkiye)

Gülşah ŞAHİN, (Erciyes Üniversitesi, Sağlık Bilimleri Enstitüsü, Klinik Beslenme Anabilim Dalı, Kayseri, Türkiye)

Serap ŞAHİN, (Erciyes Üniversitesi, Sağlık Bilimleri Enstitüsü, Klinik Beslenme Anabilim Dalı, Kayseri, Türkiye)

Murat SUNGUR, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Yoğun Bakım Bilim Dalı, Kayseri, Türkiye)

İsmail AKBUDAK, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Yoğun Bakım Bilim Dalı, Kayseri, Türkiye)

Sebahattin MUHTAROĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Muhammet GÜVEN, (Erciyes Üniversitesi Tıp Fakültesi, Tıbbi Yoğun Bakım Bilim Dalı, Kayseri, Türkiye)

Thomas ZIEGLER (Emory University Hospital, Nutrition and Metabolic Support Service, Atlanta, Georgia, USA)

Turkish Journal of Medical Sciences

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Yıl: 2020 Cilt: 50 Sayı: 4 Sayfa Aralığı: 877 - 884 Metin Dili: İngilizce DOI: 10.3906/sag-1911-165 İndeks Tarihi: 31-08-2020

The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study

Öz:

Background/aim: Adipokines play an important role in the regulation of metabolism. In critical illness, they alter serum levels and aresuspected to worsen clinical outcomes. But the effect of the route of nutrition on adipokines is not known. The purpose of this studywas to evaluate the association between the route of nutrition and adipokine levels in critically ill patients.Materials and methods: This prospective study was performed in an intensive care unit (ICU). Patients admitted to the ICU for least72 h and receiving either enteral nutrition (EN) via tube feeding or parenteral nutrition (PN) were enrolled. Serum was obtained atbaseline, 24 h, and 72 h for concentrations of leptin, adiponectin, resistin, glucagon–like peptide 1 (GLP–1), insulin–like growth factors1 (IGF–1), and ghrelin.Results: A total of 26 patients were included in the study. Thirteen patients received EN and 13 patients received PN. In the PN group,leptin level significantly increased (P = 0.037), adiponectin and ghrelin significantly decreased during follow up (P = 0.037, P = 0.008,respectively). There was no significant change between all adipokines in the EN group and resistin, IGF–1 and GLP–1 in the PN groupduring follow up. Resistin levels were markedly lower in the EN group at both 24 h (P = 0.015) and 72 h (P = 0.006) while GLP–1 levelswere higher in the EN group at baseline, 24 h, and 72 h (P = 0.018, P = 0.005, and P = 0.003, respectively). There were no differences inleptin, adiponectin, IGF–1, and ghrelin levels over time.Conclusion: The delivery of EN in critical illness was associated with decreased resistin levels and increased GLP–1 levels. Thus, theroute of nutrition may impact the clinical outcome in critical illness due to adipokines.

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1. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Molecular and cellular endocrinology 2010; 316 (2): 129-139. doi: 10.1016/j.mce.2009.08.018
2. Bays HE. “Sick fat,” metabolic disease, and atherosclerosis. American Journal of Medicine 2009; 122 (1): 26-37. doi: 10.1016/j.amjmed.2008.10.015
3. Hajri T, Gharib M, Kaul S, Karpeh Jr MS. Association between adipokines and critical illness outcomes. Journal of Trauma and Acute Care Surgery 2017; 83 (3): 507-519. doi: 10.1097/ TA.0000000000001610
4. Alipoor E, Hosseinzadeh FM, Hosseinzadeh-Attar MJ. Adipokines in critical illness: A review of the evidence and knowledge gaps. Biomedicine & Pharmacotherapy 2018; 108: 1739-1750. doi: 10.1016/j.biopha.2018.09.165
5. Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R et al. Persistent inflammation, immunosuppression and catabolism syndrome after severe blunt trauma. Journal of Trauma and Acute Care Surgery 2014; 76 (1): 21. doi: 10.1097/ TA.0b013e3182ab1ab5
6. Marques M, Langouche L. Adipose tissue and endocrine function in critical care. Diet and Nutrition in Critical Care 2015: 119-129. doi: 10.1097/CCM.0b013e318265f21c
7. Narula T, deBoisblanc BP. Ghrelin in critical illness. American Journal of Respiratory Cell and Molecular Biology 2015; 53 (4): 437-442. doi: 10.1165/rcmb.2014-0226TR
8. Stanojcic M, Finnerty CC, Jeschke MG. Anabolic and anticatabolic agents in critical care. Current Opinion in Critical Care 2016; 22 (4): 325-331. doi: 10.1097/ MCC.0000000000000330
9. Marik PE. Endocrinology of the stress response during critical illness. Critical Care Nephrology: Elsevier; 2019; 446-454.
10. Lebherz C, Schlieper G, Möllmann J, Kahles F, Schwarz M et al. GLP-1 levels predict mortality in patients with critical illness as well as end-stage renal disease. American Journal of Medicine 2017; 130 (7): 833-841. doi: 10.1016/j.amjmed.2017.03.010
11. Vassiliadi DA, Tzanela M, Kotanidou A, Orfanos SE, Nikitas N et al. Serial changes in adiponectin and resistin in critically ill patients with sepsis: associations with sepsis phase, severity, and circulating cytokine levels. Journal of Critical Care 2012; 27 (4): 400-409. doi: 10.1016/j.jcrc.2012.04.007
12. Robinson K, Prins J, Venkatesh B. Adipokines in critical illness. The Stress Response of Critical Illness: Metabolic and Hormonal Aspects: Springer; 2016; 169-183.
13. Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clinical Nutrition 2019; 38 (1): 48-79. doi: 10.1016/j. clnu.2018.08.037
14. Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). Critical Care Medicine 2016; 44 (2): 390-438. doi: 10.1177/0148607115621863
15. Tan X, Mao J, Tang H, Wang Y. Mechanisms underlying clinical efficacy of enteral nutrition in inflammatory bowel disease. International Journal of Clinical and Experimental Medicine 2017; 10(2): 2026-2035
16. Jamaludin UK, Docherty P, Preiser J-C. Incretin effects and enteral feed transitions. Diet and Nutrition in Critical Care 2015; 1269-1281. doi: 10.1007/978-1-4614-7836-2_157
17. McKenzie SJ, Premkumar R, Askelund KJ, Pendharkar SA, Phillips AR et al. The effect of enteral nutrition on adipokines in patients with acute pancreatitis. Journal of Nutritional Science 2015; 4. doi: 10.1017/jns.2015.20
18. Feng Y, Li Y, Mei S, Zhang L, Gong J et al. Exclusive enteral nutrition ameliorates mesenteric adipose tissue alterations in patients with active Crohn’s disease. Clinical Nutrition 2014; 33 (5): 850-858. doi: 10.1016/j.clnu.2013.10.009
19. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28 (7): 412-419. doi: 10.1007/bf00280883
20. Kreymann K, Berger M, Deutz Ne, Hiesmayr M, Jolliet P et al. ESPEN guidelines on enteral nutrition: intensive care. Clinical Nutrition 2006; 25 (2): 210-223. doi: 10.1016/j.clnu.2006.01.021
21. Shapiro NI, Khankin EV, Van Meurs M, Shih S-C, Lu S et al. Leptin exacerbates sepsis-mediated morbidity and mortality. Journal of Immunology 2010; 185 (1): 517-524. doi: 10.4049/ jimmunol.0903975
22. Oztekin MG, Erel S, Kismet K, Kilicoglu B, Gencay C et al. Use of serum leptin levels for determination of nutritional status and the effects of different enteral nutrients on intestinal mucosa after minor surgery: An experimental study. International Journal of Surgery 2007; 5(5): 336-341. doi: 10.1016/j.ijsu.2007.05.002
23. Yagan O, Tas N, Ayyildiz SN, Karakahya M, Noyan T. Comparison of the effects of continuous versus intermittent enteral feeding on plasma leptin and ghrelin levels in Intensive Care Units. Revista de Nutrição 2017; 30(4): 409-418. doi: 10.1590/1678-98652017000400001
24. Hillenbrand A, Weiss M, Knippschild U, Stromeyer HG, Henne-Bruns D et al. Association of adiponectin levels and insulin demand in critically ill patients. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2011; 4: 45. doi: 10.2147/DMSO.S15211
25. Rocca A, Brubaker P. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 1999; 140 (4): 1687-1694. doi: 10.1210/ endo.140.4.6643
26. Uozumi M, Sanui M, Komuro T, Iizuka Y, Kamio T et al. Interruption of enteral nutrition in the intensive care unit: a single-center survey. Journal of Intensive Care 2017; 5 (1): 52. doi: 10.1186/s40560-017-0245-9
27. Isley WL, Underwood LE, Clemmons DR. Changes in plasma somatomedin‐C in response to ingestion of diets with variable protein and energy content. Journal of Parenteral and Enteral Nutrition 1984; 8 (4): 407-411. doi: https://doi. org/10.1177/0148607184008004407
28. Hagiwara S, Iwasaka H, Shingu C, Noguchi T. Effect of enteral versus parenteral nutrition on inflammation and cardiac function in a rat model of endotoxin–induced sepsis. Shock 2008; 30(3): 280-284. doi: 10.1097/shk.0b013e318162d0fe
29. Yousef AAA-M, Amr YM, Suliman GA. The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-α in critically ill patients: a prospective observational study. Critical Care 2010; 14 (2): 33. doi: 10.1186/ cc8911
30. Kythreotis P, Kokkini A, Avgeropoulou S, Hadjioannou A, Anastasakou E et al. Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease. BMC Pulmonary Medicine 2009; 9 (1): 11. doi: 10.1186/1471-2466-9-11
31. Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C et al. Relevance of serum leptin and leptinreceptor concentrations in critically ill patients. Mediators of Inflammation 2010; 2010. doi: 10.1155/2010/473540
32. Schaffler A, Hamer O, Dickopf J, Goetz A, Landfried K et al. Admission resistin levels predict peripancreatic necrosis and clinical severity in acute pancreatitis. American Journal of Gastroenterology 2010; 105 (11): 2474-2484. doi: 10.1038/ ajg.2010.278
33. Yu P, Wang S, Qiu Z, Bai B, Zhao Z et al. Efficacy of resistin and leptin in predicting persistent organ failure in patients with acute pancreatitis. Pancreatology 2016; 16 (6): 952-957. doi: 10.1016/j.pan.2016.09.002

APA	Gündoğan K, dogan e, OZER N, GÜNEŞ ŞAHİN G, Şahin Ergül S, Sungur M, Akbudak İ, MUHTAROĞLU S, Güven M, Ziegler T (2020). The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. , 877 - 884. 10.3906/sag-1911-165
Chicago	Gündoğan Kürşat,dogan ender,OZER NURHAYAT TUGRA,GÜNEŞ ŞAHİN GÜLŞAH,Şahin Ergül Serap,Sungur Murat,Akbudak İsmail hakkı,MUHTAROĞLU Sebahattin,Güven Muhammet,Ziegler Thomas The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. (2020): 877 - 884. 10.3906/sag-1911-165
MLA	Gündoğan Kürşat,dogan ender,OZER NURHAYAT TUGRA,GÜNEŞ ŞAHİN GÜLŞAH,Şahin Ergül Serap,Sungur Murat,Akbudak İsmail hakkı,MUHTAROĞLU Sebahattin,Güven Muhammet,Ziegler Thomas The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. , 2020, ss.877 - 884. 10.3906/sag-1911-165
AMA	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. . 2020; 877 - 884. 10.3906/sag-1911-165
Vancouver	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. . 2020; 877 - 884. 10.3906/sag-1911-165
IEEE	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T "The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study." , ss.877 - 884, 2020. 10.3906/sag-1911-165
ISNAD	Gündoğan, Kürşat vd. "The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study". (2020), 877-884. https://doi.org/10.3906/sag-1911-165

APA	Gündoğan K, dogan e, OZER N, GÜNEŞ ŞAHİN G, Şahin Ergül S, Sungur M, Akbudak İ, MUHTAROĞLU S, Güven M, Ziegler T (2020). The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. Turkish Journal of Medical Sciences, 50(4), 877 - 884. 10.3906/sag-1911-165
Chicago	Gündoğan Kürşat,dogan ender,OZER NURHAYAT TUGRA,GÜNEŞ ŞAHİN GÜLŞAH,Şahin Ergül Serap,Sungur Murat,Akbudak İsmail hakkı,MUHTAROĞLU Sebahattin,Güven Muhammet,Ziegler Thomas The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. Turkish Journal of Medical Sciences 50, no.4 (2020): 877 - 884. 10.3906/sag-1911-165
MLA	Gündoğan Kürşat,dogan ender,OZER NURHAYAT TUGRA,GÜNEŞ ŞAHİN GÜLŞAH,Şahin Ergül Serap,Sungur Murat,Akbudak İsmail hakkı,MUHTAROĞLU Sebahattin,Güven Muhammet,Ziegler Thomas The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. Turkish Journal of Medical Sciences, vol.50, no.4, 2020, ss.877 - 884. 10.3906/sag-1911-165
AMA	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. Turkish Journal of Medical Sciences. 2020; 50(4): 877 - 884. 10.3906/sag-1911-165
Vancouver	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study. Turkish Journal of Medical Sciences. 2020; 50(4): 877 - 884. 10.3906/sag-1911-165
IEEE	Gündoğan K,dogan e,OZER N,GÜNEŞ ŞAHİN G,Şahin Ergül S,Sungur M,Akbudak İ,MUHTAROĞLU S,Güven M,Ziegler T "The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study." Turkish Journal of Medical Sciences, 50, ss.877 - 884, 2020. 10.3906/sag-1911-165
ISNAD	Gündoğan, Kürşat vd. "The association between the route of nutrition and serum levels of adipokines in critical illness: a pilot study". Turkish Journal of Medical Sciences 50/4 (2020), 877-884. https://doi.org/10.3906/sag-1911-165