Yıl: 2019 Cilt: 7 Sayı: 9 Sayfa Aralığı: 1249 - 1262 Metin Dili: Türkçe DOI: 10.24925/turjaf.v7i9.1249-1262.2141 İndeks Tarihi: 01-09-2020

Bal Arısı Ürünleri ve Apiterapi

Öz:
Bal arısı ürünleri içerisinde en çok bilineni baldır. Oysa bal dışında besleyici ve tedaviye desteközellikte başka arı ürünleri de vardır. Polen, arı sütü ve propolis son yılarda yapılan araştırma sayısıen fazla olan arı ürünleri arasında yerini almıştır. Bununla birlikte arı ekmeği (perga) ve erkek arılarvası (apilarnil) gibi ürünler ise çok bilinmeyen ve hakkında az çalışma olan ürünlerdir. Apiterapi;arı ve arı ürünlerinin koruyucu ve bazı hastalıkların tedavisinde tamamlayıcı uygulama yöntemiolarak kullanılması biçimidir. Ancak bu uygulamaların başarılı bir şekilde yapılabilmesi için buürünlerin kimyasal ve biyolojik özelliklerinin bilinmesi gereklidir. Bu amaçla bu çalışmada arıürünlerinin tanımı, kimyasal ve biyolojik özellikleri ile terapötik aktivitelerine yer verilmiştir.
Anahtar Kelime:

Honeybee Products and Apitherapy

Öz:
Honey is the most known among the honeybee products. But apart from honey, there are other bee products that are nutritious and supportive of treatment. Pollen, royal jelly, and propolis are among the bee products that have the highest number of researches made in the last years. However, products such as bee bread (perga) and drone larvae (apilarnil) are very unknown products with little work. Apitherapy; bee and bee products as a method of complementary application in the protection and treatment of certain diseases. However, in order for these applications to be successful, the chemical and biological properties of these products need to be known. For this purpose, the definition, chemical and biological properties and therapeutic activities of bee products are included in this study.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • Abouda Z, Zerdani I, Kalalou I, Faid M, Ahami MT. 2011. The antibacterial activity of Moroccan bee bread and bee-pollen (fresh and dried) against pathogenic bacteria. Res J Microbiol. 6: 376-384.
  • Akçiçek E, Yücel B. 2015. Apiterapi’de Apilarnil. Arı Ürünleri ve Sağlık (Apiterapi) Sidas Yayınevi, İzmir. s:183-190, ISBN: 978-605-5267-26-1.
  • Aljadi AM, Kamaruddin M. 2004. Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chem. 85: 513–518.
  • Almaraz-Abarca N, Campos MG, Avila-Reyes JA, NaranjoJimenez N, Corral JH, Gonzalez-Valdez LS. 2007.
  • Antioxidant activity of polyphenolic extract of monofloral honeybee-collected pollen from mesquite (Prosopis juliflora, Leguminosae). J Food Comp Anal. 20: 119-124.
  • Altan Ö, Yücel B, Açıkgöz Z, Seremet C, Kösoğlu M, Turgan N, Özgönül AM. 2013. Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth. British Poult Sci. 54(3): 355-361.
  • Alvarez-Suarez JM, Tulipani S, Diaz D, Estevez Y, Romadini S, Giampieri F, Damiani E, Astolfi P, Bompadre S, Battino M. 2010. Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food Chem Toxicol. 48: 2490–2499.
  • Anonim 2012. Türk Gıda Kodeksi Bal Tebliği” http://www.resmigazete.gov.tr/eskiler/2012/07/20120727- 12.htm (Son erişim tarihi: 3.7.2019).
  • Arcot J, Brand-Miller M. 2005. “A preliminary assessment of the glycemic index of honey”. Australian Government Rural Industries Research and Development Corporation. RIRDC Publication No 05/027 RIRDC Project No UNS-17A.
  • Arslan S, Yazıcı RA, Görücü J, Pala K, Antonson DE, Antonson SE, Silici S. 2012a. Comparison of the effects of Er, Cr: YSGG laser and different cavity disinfection agents on microleakage of current adhesives. Lasers Med Sci. 27(4): 805-11.
  • Arslan S, Silici S, Percin D, Koç AN, Er Ö. 2012b. Antimicrobial activity of poplar propolis on mutans streptococci and caries development in rats.Turk J Biol 36 (1): 65-73.
  • Arvanitoyannis S, Chalhoub C, Gotsiou P, Lydakis-Simantiris N, Kefalas P. 2005. Novel quality control methods in conjunction with chemometrics (multivariate analysis) for detecting honey authenticity. Critic Rev Food Sci Nutr. 45 (3): 193–203.
  • Atayoğlu AT, Soylu M, Silici S, İnanç N. 2016. Glycemic index values of monofloral Turkish honeys and the effect of their consumption on glucose metabolism. Turk J Med Sci. 46: 483-488 (2016).
  • Bankova VS, De Castro SL, Marcucci MC. 2000. Propolis: recent advances in chemistry and plant origin. Apidologie, 31: 3–15
  • Bankova V, De Castro SL, Marcucci MC. 2005. Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol. 100: 114–117.
  • Barnutiu LI, Marghitaş LA, Dezmirean D, Bobiş O, Mihai C, Pavel C. 2013. Physico-chemical composition of Apilarnil (Bee drone larvae). Seria Zootechnie 59: 199-202.
  • Bastos DHM, Barth OM, Rocha CI, Cunha IBS, Carvalho PO, Torres ES, Michelan M. 2004. Fatty acid composition and palynological analysis of bee (Apis) pollen loads in the states of Sao Paulo and Minas Gerais, Brazil. J Apic Res. 43 (2): 35-39.
  • Basım E, Basım H, Özcan M. 2006. Antibacterial activities of Turkish pollen and propolis extracts against plant bacterial pathogens. J Food Engin. 77: 992–996.
  • Bertocelj J, Dobersek U, Jamnik M, Golob T. 2007. Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey. Food Chem.105: 822–828.
  • Bogdanov S. 1997. Nature and origin of the antibacterial substances in honey. Lebensmittel-Wissenschaft Technol. 30(7): 748–753.
  • Bogdanov S, Jurendic T, Sieber R, Gallmann P. 2008. Honey for nutrition and health: A review. J Am Coll Nutr. 27(6): 677– 89.
  • Bogdanov S. 2011. Pollen: Nutrition, Functional Properties, Health: A Review. Bee Prod Sci. 1-34.
  • Bogdanov S. 2012. Royal jelly, bee brood: Composition, Health, medicine: A Review Bee Product Science.www. beehexagon.net. (Son erişim tarihi: 3.7.2019)
  • Bolatovna KS, Rustenov A, Eleqalieva N, Omirzak T, Akhanov UK. 2015. Improving reproductive qualities of pigs using the drone brood homogenate. Bio Med (Aligarh), 7 (2): BM-091- 15.
  • Bonvehi JS, Jorda E. 1997. Nutrient composition and microbiological quality of honeybee-collected pollen in Spain. J Agric Food Chem. 45(3): 725-732.
  • Bratter C, Tregel M, Liebenthal C, Volk HD. 1999. Prophylactic effectiveness of propolis for immunostimulation a clinical pilot study. Forschende Komplementarmedizine 6 (5): 256- 60.
  • Brudzynski K, Kim L. 2011. Storage-induced chemical changes in active components of honey de-regulate its antibacterial activity. Food Chem. 126: 1155–1163.
  • Burdock GA. 1998. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 36: 347-363.
  • Calderone NW, Johnson BR. 2002. The within nest behaviour of honeybee pollen foragers in colonies with a high or low need for polen. Anim Behav. 63: 749-75.
  • Campos MG, Markham K, Cunha A. 1997. Bee pollen: composiiton properties and applications. In Mizrahi, A (Ed) Bee Products. Plenum Publishing Company; p: 93-100, London, UK
  • Campo Fernandez M, Cuesta-Rubio O, Rosado Perez A, Montes De Oca Porto, R, Marguez Hernandez I, Piccinelli AL, Rastrelli L. 2008. GC–MS determination of isoflavonoids in seven red Cuban propolis samples. J Agric Food Chem. 56: 9927–9932.
  • Cho E, Lee JD, Cho SH. 2011.Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 23: 85-88.
  • Constantin D. 1989. Rezultate obpinute in tratamentul cu apilarnil potent a tulburarilar de dinamicamsexuale. Romanian Apic. 10: 21.
  • Cooper RA, Molan PC, Harding KG. 1999. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J Royal Soc Med. 92: 283-285.
  • Crane E. 1976. Honey, A comprehensive survey. International Bee Research Association. London: Heinemann.
  • Cuesta A, Rodriguez A, Esteban MA, Mesequer J. 2005. In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses. Fish Selfish Immunol. 18 (1): 71- 80.
  • Çam Y, Koç AN, Silici S, Güneş V, Buldu H, Onmaz AC, Kasap FF. 2009. Treatment of dermatophytosis in young cattle with propolis and Whitfield’s ointment. Vet Record. 165(2): 57- 58.
  • Çetin E, Kanbur M, Silici S, Eraslan G. 2010a. Propetamphosinduced changes in hematological and biochemical parameters of female rats: protective role of propolis. Food Chem Toxicol. 48 (7): 1806-1810.
  • Çetin E, Silici S, Çetin N. 2010b. Effects of diets containing different concentrations of propolis on hematological and immunological variables in laying hens. Poult Sci. 89 (8): 1703-1708.
  • D’Arcy B, Caffin N, Bhandari B, Squires N, Fedorow P, Mackay D. 1999. Australian liquid honey in commerical bakery products. Australian Government Rural Industries Research and Development Corporation. RIRDC Publication No.: 99/145 RIRDC Project No: UQ-50A.
  • Dobson HEM, Peng YS. 1997. Digestion of pollen components by larvae of the flower-specialist bee helostoma florisomne (Hymenoptera: Megachilidae). J Insect Physiol. 43: 89-100.
  • Denli M, Cankaya S, Silici S, Okan F, Uluocak AN. 2005. Effect of dietary addition of Turkish propolis on the growth performance, carcass characteristics and serum variables of quail (Coturnix coturnix japonica). Asian-Aust J Anim Sci. 18(6): 848-854.
  • Elkins R. 1996. Bee polen royal jelly propolisand honey, Woodland Publishing, London.
  • Elnagar S. 2010. Royal jelly counteracts bucks' summer infertility. Anim Rep Sci. 121: 174-180.
  • English R, Lewis J. 1991. Nutritional Values of Australian Foods, Canberra, Australian Government Publishing Service, Australia.
  • Eraslan G, Kanbur M, Silici S, Karabacak M. 2008. Effects of cypermethrin on some biochemical changes in rats: The protective role of propolis. Exp Anim. 57(5): 453-460.
  • Eroğlu HE, Ozkul Y, Tatlisen A, Silici S. 2008. Anticarcinogenic and antimitotic effects of Turkish propolis and mitomycin-C on tissue cultures of bladder cancer. Nat Prod Res. 22(12): 1060-1066.
  • Fınke MD. 2005. Nutrient composition of bee brood and its potential as human food. Ecol Food Nutr. 44(4): 257-270.
  • Gardana C, Scaglianti M, Pietta P, Simonetti P. 2007. Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 4: 390–399.
  • Gencay Ö, Sorkun K. 2006. Microscopic analysis of propolis samples collected from east Anatolia (Kemaliye-Erzincan). FABAD J Pharm Sci. 31: 192-197.
  • Ghisalberti EL. 1979. Propolis: A Review. Bee World 60(2): 59- 84.
  • Gonzalez Parama´s AM, Barez JAG, Marcos CC, GarcıaVillanova RJ, Sanchez JS. 2006. HPLC-fluorimetric method for analysis of amino acids in products of the hive (honey and bee-pollen). Food Chem. 95: 148–156.
  • Greenaway W, May J, Scaysbrook T, Whatley FR. 1991. Identification by gas chromatography mass spectrometry of 150 compounds in propolis. Z. Naturforsch. 46c: 111-121.
  • Guo H, Kozuma Y, Yonekura M. 2009. Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chem. 113(1): 238–245.
  • Gurr M. 1997. Nutritional and Health Aspects of Sugars. Evaluation of New Findings. ILSI series.
  • Gülçin I, Bursal E, Sehitoğlu MH, Birsel M, Gören AC. 2010. Polyphenols contents and antioxidant activity of lyophilized aqueus extract of propolis from Erzurum, Turkey. Food Chem Toxicol. 48: 2227-2238.
  • Harborne JB, Williams CA. 2000. Advances in flavonoid research since 1992. Phytochem. 55: 481–504.
  • Havsteen BH. 1983. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32: 1141–1448.
  • Heitkamp K. 1984. Pro und Kontra Honig-Sind Aussagen zur Wirkung des Honigs “wissenschaftlich hinreichend gesichert?”. Schriften zur Oectrophologie, 1-60.
  • Hernandez IM, Cuesta-Rubio O, Fernández MC, Rosado Perez A, Montes de Oca Porto R, Piccinelli AL, Rastrelli L. 2010. Studies on the constituents of yellow Cuban propolis: GC– MS determination of triterpenoids and flavonoids. J Agric Food Chem., 58: 4725–4730.
  • Herbert EW, Shimanuki H. 1978. Chemical composition and nutritive value of bee collected and bee stored pollen. Apidologie 9(1): 33-40.
  • Hertog MGL, Hollman PC, Katan MB. 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in Netherlands. Nutr Cancer Int J. 20: 21-29.
  • Human H, Nicolson SW. 2006. Nutritional content of fresh, beecollected and stored pollen of Aloe greatheadii var. davyana (Asphodelaceae). Phytochem. 67: 1486-1492.
  • Isidorov VA, Czyzewska U, Isidorova AG, Bakier S. 2009. Gas chromatographic and mass spectrometric characterization of organic acids extracted from some preparations containing lyophilized royal jelly. J Chromatogr. B, 877, 3776–3780.
  • Isıdorov VA, Bakier S, Stocki M. 2016. GC-MS investigation of the chemical composition of hoeybee drone and queen larva homogenate. J Apic Res. 60 (1): 111-120.
  • Jamnik P, Goranovic D, Raspor P. 2007. Antioxidative action of royal jelly in the yeast cell. Exp Gerontol. 42, 594–600.
  • Jasprica I, Mornar A, Debeljak Z, Smolcic-Bubalo A, MedicSaric M, Mayer L, Romic Z, Bucan K, Balog T, Sobocanec S, Sverko V. 2007. In vivo study of propolis supplementation effects on anti-oxidative status and red blood cells. J Ethnopharmacol.110: 548-554.
  • Kamakura M, Fukuda T, Fukushima M, Yonekura M. 2001. Storage dependent degradation of 57-kDa protein in royal jelly: A possible marker for freshness. Biosci Biochem Biotechnol. 65: 277–284.
  • Kanbur M, Eraslan G, Silici S. 2009. Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotox Environ Safety. 72(3): 909-915.
  • Kaplan M, Karaoğlu Ö, Eroğlu N, Silici S. 2016. Fatty acid and proximate composition of bee bread. Food Technol Biotechnol 54(4): 497-504.
  • Karabağ K, Dinç H, Selçuk M. 2010. Arı sütünün insan sağlığı için önemi. Ulusal Meslek Yüksekokulları Öğrenci Sempozyumu, Düzce.
  • Karataş F, Şerbetçi Z. 2008. Arı polenlerindeki adrenalin ve noradrenalin miktarlarının HPLC ile belirlenmesi. Sci Engineer J Fırat Univ. 20(3): 419-422.
  • Kartal M, Kaya S, Kurucu S. 2002. GC-MS Analysis of propolis samples from two diferent regions of Turkey. Z. Naturforsch. 57: 905-909.
  • Kılıçoğlu B, Kısmet K, Koru O, Tanyuksel M, Oruç MT, Sorkun K, Akkus MA. 2006. The scolicidal effects of honey. Adv Therapy 23: 1077-1083.
  • Koç AN, Silici S, Ayangil D, Ferahbaş A, Çankaya S. 2005. Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay. Mycoses 48: 205-210.
  • Koç AN, Silici S, Mutlu-Sarıgüzel F, Sagdic O. 2007. Antifungal activity of propolis in four different fruit juices.Food Technol Biotechnol. 45 (1): 57-61.
  • Koç AN, Silici S, Ercal BD, Kasap F, Hörmet-Öz HT, MavusBuldu H. 2009. Antifumgal activity of Turkish honey against Candida spp. and Trichosporon spp: an in vitro evaluation. J Med Mycol. 47(7): 707-712.
  • Konar V, Özdemir, FA, Karataş F. 2010. Ticari arı polenlerinde b vitamini miktarlarının araştırılması. Fırat Univ J Sci., 22: 61-64.
  • Kogalniceanu S, Lancrajan I, Ardelean G. 2010. Changes of the glucidic metabolism determined by the physical effort of the treatment with the Aslavital and Apilarnil. J Med Aradian, 3: 33-41.
  • Kramer KJ, Tager HS, Childs CN, Speirs RD. 1977. Insulin like hypoglycemic and immunological activities in honey bee royal jelly. J Insect Physiol. 23: 293–295.
  • Krell R. 1996. Value-added products from beekeeping. FAO Agricultural Services Bulletin No. 124 Food and Agriculture Organization of the United Nations Rome.
  • Küçük M, Kolaylı S, Karaoglu S, Ulusoy E, Baltaci C, Candan F. 2007. Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chem.100: 526–534.
  • Kühnau J. 1976. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 24: 117-191.
  • Lachman J, Orsak M, Hejtmankova A, Kovarova E. 2010. Evaluation of antioxidant activity and total phenolics of selected Czech honeys. Leben Wissen Technol. 43: 52–58.
  • Lee SY, Lee DR, You CE, Park MY, Son SJ. 2006. Autosensitization dermatitis associated with propolisinduced allergic contact dermatitis. J Drugs Dermatol. 5: 458-460.
  • Linskens HF, Jorde W. 1997. Pollen as food and medicine – A review. Economic Botany 51: 78-86.
  • Liebelt RA, Lyle D, Walker J. 1994. Effects of a bee polen diet on su and growth of ınbred strains of mice. Am Bee J. 134: 615-620.
  • Loper GM, Standifer LN, Thompson MJ, Gilliam M. 1980. Biochemistry and microbiology of bee collected almond (Prunus dulcis) pollen and bee bread. I. Fatty acids, sterols, vitamins, and minerals. Apidologie 11(1): 63-73.
  • Luz CFP, Barth OM. 2012. Pollen analysis of honey and beebread derived from Brazilian mangroves. Braz J Botany 35(1): 79- 85.
  • Majtan J, Kovacova E, Bilikova K, Simuth J. 2006. The immunostimulatory effect of the recombinant apalbumin 1- major honeybee royal jelly protein-on TNFalpha release. Int Immunopharmacol. 6: 269–278.
  • Malika N, Mohamed F, Chakib EA. 2004. Antimicrobial activities of natural honey from aromatic and medicinal plants on antibio-resistant strains of bacteria. Int J Agric Biol. 6(2): 289-293.
  • Maruyama H, Yoshida C, Tokunaga K, Araki Y, Mishima S. 2005. The effect of a peptide (Ile-Val-Tyr) derived from royal jelly treated with protease on blood pressure of spontaneously hypertensive rat. The Japanese Soc. Food Sci Technol - Nippon Shokuhin Kagaku Kogaku Kaishi, 52: 491-494.
  • Mahan LK. 1990. Nutrition and the allergic athlete. Japan J Pharmacol 53: 157-64.
  • Mandal MD, Mandal S. 2011. Honey: its medicinal property and antibacterial activity. Asian Pacific J Tropic Biomed. 1(2):154-160.
  • Matsuka M, Wataa N, Taceuchi K. 1973. Analyses of the food of larval drone honeybees. J Apic Res. 12: 3-7.
  • Meda A, Lamien CE, Millogo J, Romito M, Nacoulma OG. 2004. Therapeutic uses of honey and honeybee larvae in central Burkina Faso. J Ethnopharmacol. 95:103-107.
  • Medeiros KC, Figueiredo CA, Freire KR, Santos FA, AlcantaraNeves NM, Silva TM, Piuvezam MR. 2008. Anti allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. J Ethnopharmacol. 119 (1): 41- 46.
  • Mohapatra DP, Thakur V, Brar SK. 2011. Antibacterial efficacy of raw and processed honey. Biotechnol Res Int. 917505.
  • Mohammadzadeh S, Shariatpanahi M, Hamedi M, Ahmadkhaniha R, Samadi N, Ostad SN. 2007. Chemical composition, oral toxicity and antimicrobial activityof Iranian propolis. Food Chem. 103: 1097-1103.
  • Mutsaers M, Blitterswijk H, Leven L, Kerkvliet J, Waerdt J. 2005. Bee products properties, processing and marketing. Agrodok series, 42.
  • Nagai T, Nagashima T, Suzuki N, Inoue R. 2005. Antioxidant activity and angiotensin-I converting enzyme inhibition by enzymatic hydolysates from bee bread. Z Natuforsch. 60c: 133-138.
  • Nagai T, Sakai M, Inoue R, Inoue H, Suzuki N. 2001. Antioxidative activities of some commercially honeys, royal jelly and propolis. Food Chem. 75(2): 240-244.
  • Okamoto I, Taniguchi Y, Kunikata T, Kohno K, Iwaki K, Ikeda M. 2003. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci. 73: 2029–2045.
  • Öksüz H, Duran N, Tamer C, Cetin M, Silici S. 2005. Effect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbits. Opthal Res. 37(6): 328-334.
  • Özcan M. 1999. Antifungal properties of propolis. Grasas y Aceites 50(5): 395-398.
  • Özcan M, Ceylan A, Ünver A, Yetişir R. 2003a. Antifungal effect of pollen and propolis extracts colleceted from different regions of Turkey. Uludağ Arıcılık Dergisi 3: 33-36.
  • Özcan M, Ozcan M, Ayar A. 2003b. Effect of propolis extracts on butter stability. J Food Qual. 26(1): 65-73.
  • Özcan M, Ünver A, Ceylan DA, Yetisir R. 2004. Inhibitory effect of pollen and propolis extracts. Mol Nutr Food Res 48(3): 188-194.
  • Özbilge H, Kaya EG, Albayrak S, Silici S. 2010. Anti-leishmanial activities of ethanolic extract of Kayseri propolis. African J Microbiol Res 4(7): 556-560.
  • Özkök D, İşcan K, Silici S. 2013. Effects of dietray propolis supplementation on performance and egg quality in laying hens. J Anim vet Adv. 12(2): 269-275.
  • Özkul Y, Silici S, Eroğlu E. 2005. The anticarcinogenic effect of propolis in human lymphocytes culture. Phytomed. 12(10): 742-747.
  • Özen T, Kılıç A, Bedir O, Koru Ö, Sorkun K, Tanyüksel M, Kılıç S, Gencay Ö, Yıldız O, Baysallar M. 2010. In vitro activity of Turkish propolis samples against anaerobic bacteria causing oral cavity infections. Kafkas Uni Vet Fak Der. 16(2): 293- 298.
  • Percie Du Sert P. 2009a. Les pollens apicoles. Phytotherapy 7:75- 82.
  • Percie Du Sert P. 2009b. Probiotic effect of lactic acid bacteria in fresh pollen, 41st Apimondia Congress Montpellier, France.
  • Popova M, Silici S, Kaftanoglu O, Bankova V. 2005. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition. Phytomed. 12(3), 221-228.
  • Popova MP, Bankova VS, Bogdanov S, Tsvetkova I, Naydenski C, Marcazzan GL, Sabatini AG. 2007. Chemical characteristics of poplar type propolis of different geographic origin. Apidologie 38: 306-311.
  • Pernal SF, Currie RW. 2001. The influence of pollen quaality on foraging behavior in honeybees (Apis mellifera L.). Behav Ecol Sociobiol. 51: 53-68.
  • Ramadan A, Soliman G, Mahmoud SS, Nofal SM, AbdelRahman RF. 2012. Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts. J saudi Chem Soc. 16(1): 13–21.
  • Romanelli P, Miteva M, Schwartzfarb E. 2009. P63 is a helpful tool in the diagnosis of a primary cutaneous carcinosarcoma. J Cutan Pathol. 36: 280–282.
  • Rios AM, Novoa ML, Vit P. 2001. Effects of extraction, storage conditions and heating treatment on antibacterial activity of Zanthoxylum fagara honey from, Cojedes, Venezuela. Revoluçao Cientifica 11(5): 397-402.
  • Sağdıç O, Silici S, Yetim H. 2007. Fate of Escherichia coli and E.coli 0157:H7 in apple juice treated with propolis extract. Ann Microbiol 57(3): 345-348.
  • Saric A, Balog T, Sobocanec S, Kusic B, Sverko V, Rusak G, Likic S, Bubalo D, Pinto B, Reali D, Marotti T. 2009. Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. Food Chem Toxicol. 47: 547–554.
  • Schmidt JO, Buchmann SL.1992. Other products of the hive. In: The Hive and the Honeybee. J.M. Graham, ed. Dadant & Sons, p: 927-988.Hamilton, Illinois, USA.
  • Sforcin JM, Bankova V. 2011. Propolis: Is there a potential for the development of new drugs?. J Ethnopharmacol. 133: 253– 260.
  • Sorkun K, Süer B, Salih B. 2001. Determination of chemical composition of Turkish propolis. Z Naturforsch. 56c: 666- 668.
  • Seven I, Tatlı-Seven P, Silici S. 2011. Effects of dietary Turkish propolis as alternative to antibiotic on growth and laying performances, nutrient digestibility and egg quality in laying hens under heat stress. Rev Med Vet. 162(4): 186-191.
  • Shinmei Y, Yano H, Kagawa Y, Izawa K, Akagi M, Inoue T, Kamei C. 2009. Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. Immunopharmacol Immunotoxicol. 31(4): 688–693.
  • Silici S, Koc AN, Mutlu-Sarıgüzel F, Sağdıç O. 2005. Mould inhibition in different fruit juices by propolis. Arch Lebensmittel. 56(4): 87-90.
  • Silici S, Gokceoğlu M. 2007. Polen analysis of honeys from Mediteranean region of Anatolia. Grana 46: 57-64.
  • Silici S, Kutluca S. 2005. Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. J Ethnopharmacol. 99: 69-73.
  • Silici S, Unlu M, Vardar-Unlu G. 2007. Antibacterial activity and phytochemical evidence for the plant origin of Turkish propolis from different regions. Eorld J Microbiol Biotechnol. 23(12): 1797-1803.
  • Silici S. 2015. Pre-clinical studies on propolis. Erciyes J Ins Sci Technol. 31(3):185-191.
  • Silva TMS, Camara CA, Silva Lins AC, Barbosa-Filho JM, Silva EMS, Freitas BM, Santos FAR. 2006. Chemical composition and free radical scavenging activity of pollen loads from stingless bee Melipona subnitida Ducke. J Food Comp Anal. 19: 507-511.
  • Simpopoulos AP. 2004. Omega 3 fatty acids and antioxidants in edible wild plants. Biol Res. 37: 263-277.
  • Snowdon JA, Clier DO. 1996. Microorganisms in honey. Int J Food Microbiol. 31: 1-26.
  • Stephens MJ, Schlothauer RC, Morris BD, Yang D, Fearnley L, Greenwood DR, Loomes KM. 2010. Phenolic compounds and methylglyoxal in some New Zealand manuka and kanuka honeys. Food Chem. 120: 78–86.
  • Stocker A, Schramel P, Kettrup A, Bengsch E. 2005. Trace and mineral elements in royal jelly and homeostatic effects. J Trace Element Med Biol. 19:183–189
  • Szczesna T. 2006. Long-chain fatty acids composition of honeybee-collected pollen. J Apic Sci. 50(2): 65-79.
  • Saa-Otero MP, Diaz-Losada, Fernandez-Gomez E. 2000. Anlaysis of fatty acids, proteins and ethereal extract in honeybee pollen. Considerations of their floral origin. Grana 39(4):175-181.
  • Stangaciu S. 1999. Apitherapy course notes, Constanta Apitherapy Research Hospital, p:286, Bucuresti-Romania. Tsurama Y, Maruyama H, Araki Y. 2011. Effect of a Glycoprotein (Apisin) in Royal Jelly on Proliferation and Differentiation in Skin Fibroblast and Osteoblastic Cells. The Japanese Society for Food Science and Technology -Nippon Shokuhin Kagaku Kogaku Kaishi 58 (3): 121-126.
  • Viuda-Martos M, Ruiz-Navajas Y, Fernandez-Lopez J, PerezAlvarez JA. 2008. Functional properties of honey, propolis, and royal jelly. J Food Sci. 73(9): 117–24.
  • Velikova M, Bankova V, Sorkun K, Popov S, Kujumgiev A. 2000. Chemical composition and biological activity of propolis from Turkish and Bulgarian origin. Mellifera, 1(1): 57-59.
  • Valencia-Barrera RM, Herrero B, Molnar T. 2000. Pollen and organoleptic analysis of honeys in Leon province (Spain). Grana 39: 133- 140.
  • Von Schacky C, Harris WS. 2007. Cardiovascular benefits of omega-3 fatty acids. Cardiovas Res. 73: 310–315.
  • Williams RJ, Spencer JPE, Rice-Evans CA. 2004. Flavonoids: antioxidants or signaling molecules? Free Rad Biol Med. 36: 838-849.
  • Yonar ME, Yonar SM, Ural MŞ, Silici S, Düşükcan M. 2012. Protective role of propolis chlorpyrifos-induced changes in the haematological parameters and the oxidative/ antioxidative status of Cyprinus carpio carpio”. Food Chem Toxicol. 50(8): 2703-2708.
  • Yonar ME, Yonar SM, Silici S. 2011. Protective effect of propolis against oxidative stress and immunosuppression induced by oxytetracycline in rainbow trout (Oncorhynchus mykiss, W.). Fish Shelfish Immunol. 31(2): 318-325.
  • Yonar SM, Ural MŞ, Silici S, Yonar ME. 2014. Malathioninduced changes in the haematological profile, the immun response, and the oxidative/antioxidant status of Cyprinus carpio carpio: Protective role of propolis. Ecotoxicol Environ Safety. 102: 202-209.
  • Yücel B, Açıkgöz Z, Bayraktar H, Seremet Ç. 2011. The effects of apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers. J Anim Vet Adv. 10(17): 2263-2266.
  • Walgrave SE, Warshaw EM, Glesne LA. 2005. Allergic contact dermatitis from propolis. Dermatitis 16: 209-215.
  • Weston RJ, Brocklebank LK, Lu Y. 2000. Identification and quantitative levels of antibacterial components of some New Zealand honeys. Food Chem. 70i: 427–435.
  • Zeina B, Othman O, Al-Assad S. 1996. Effect of honey versus thyme on Rubella virus in survival vitro. J Alter Comp Med. 2: 345-348.
APA Silici S (2019). Bal Arısı Ürünleri ve Apiterapi. , 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
Chicago Silici Sibel Bal Arısı Ürünleri ve Apiterapi. (2019): 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
MLA Silici Sibel Bal Arısı Ürünleri ve Apiterapi. , 2019, ss.1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
AMA Silici S Bal Arısı Ürünleri ve Apiterapi. . 2019; 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
Vancouver Silici S Bal Arısı Ürünleri ve Apiterapi. . 2019; 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
IEEE Silici S "Bal Arısı Ürünleri ve Apiterapi." , ss.1249 - 1262, 2019. 10.24925/turjaf.v7i9.1249-1262.2141
ISNAD Silici, Sibel. "Bal Arısı Ürünleri ve Apiterapi". (2019), 1249-1262. https://doi.org/10.24925/turjaf.v7i9.1249-1262.2141
APA Silici S (2019). Bal Arısı Ürünleri ve Apiterapi. Türk Tarım - Gıda Bilim ve Teknoloji dergisi, 7(9), 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
Chicago Silici Sibel Bal Arısı Ürünleri ve Apiterapi. Türk Tarım - Gıda Bilim ve Teknoloji dergisi 7, no.9 (2019): 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
MLA Silici Sibel Bal Arısı Ürünleri ve Apiterapi. Türk Tarım - Gıda Bilim ve Teknoloji dergisi, vol.7, no.9, 2019, ss.1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
AMA Silici S Bal Arısı Ürünleri ve Apiterapi. Türk Tarım - Gıda Bilim ve Teknoloji dergisi. 2019; 7(9): 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
Vancouver Silici S Bal Arısı Ürünleri ve Apiterapi. Türk Tarım - Gıda Bilim ve Teknoloji dergisi. 2019; 7(9): 1249 - 1262. 10.24925/turjaf.v7i9.1249-1262.2141
IEEE Silici S "Bal Arısı Ürünleri ve Apiterapi." Türk Tarım - Gıda Bilim ve Teknoloji dergisi, 7, ss.1249 - 1262, 2019. 10.24925/turjaf.v7i9.1249-1262.2141
ISNAD Silici, Sibel. "Bal Arısı Ürünleri ve Apiterapi". Türk Tarım - Gıda Bilim ve Teknoloji dergisi 7/9 (2019), 1249-1262. https://doi.org/10.24925/turjaf.v7i9.1249-1262.2141