BACKGROUND/AIMSTo investigate the clinical utility of complete blood count (CBC) parameters in the preoperative diagnosis of lymph node involvement(LNI) in endometrial carcinomas (ECs).MATERIAL and METHODSWe conducted a retrospective study of 159 patients with ECs who underwent complete staging surgery at a tertiary center between2007 and 2017. After demographic characteristics and preoperative CBC parameters were retrieved from the patients’ medical records,the patients were grouped according to lymph node status (positive and negative) and compared. Variables with p<0.05 were includedin the logistic regression analysis, and receiver operating characteristic curve analysis was used to determine the cut-off values forpredicting LNI.RESULTSThe mean age of the patients was 59.1 years, and 14 (8.8%) patients had LNI. The mean white blood cell, neutrophil, and platelet counts;plateletcrit level; and neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were significantly higher in patients with LNI. Logisticregression analysis identified an independent association between increased neutrophil count and LNI (odds ratio 5.12; p<0.05). Theoptimal cut-off value was 4.85 (×103/μL) (sensitivity, 77.4% and specificity, 74.2%). A cut-off of 6.25 (×103/μL) was used to identify LNI with100% specificity.CONCLUSIONAn increased neutrophil count can be considered a useful additional tool for the preoperative diagnosis of LNI.