Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue

KARAARSLAN, Numan; SIMSEK, Abdullah Talha; BİRCAN, Rifat; Yılmaz, İbrahim; özbek, hanefi; CALISKAN, Tezcan; SIRIN, Duygu YASAR; KAPLAN, Necati

doi:10.5137/1019-5149.JTN.24447-18.3

Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue

Necati KAPLAN, (İstanbul Rumeli Üniversitesi, Çorlu Reyap Hastanesi, Nöroşirurji Kliniği, Tekirdağ, Türkiye)

İbrahim YILMAZ, (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Numan KARAARSLAN, (Namık Kemal Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Tekirdağ, Türkiye)

Duygu YASAR SIRIN, (Namık Kemal Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Tekirdağ, Türkiye)

Abdullah Talha SIMSEK, (Namık Kemal Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Tekirdağ, Türkiye)

Tezcan CALISKAN, (Namık Kemal Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Tekirdağ, Türkiye)

Rifat BİRCAN, (Namık Kemal Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Tekirdağ, Türkiye)

HANEFİ ÖZBEK (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Neurosurgery

1 0

Yıl: 2019 Cilt: 29 Sayı: 4 Sayfa Aralığı: 522 - 529 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.24447-18.3 İndeks Tarihi: 08-09-2020

Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue

Öz:

AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebraldisc tissue cells.MATERIAL and METHODS: Primary cell cultures were established using tissues obtained through decompressive laminectomy,traumatic intervertebral disc herniation excision, and posterior transpedicular stabilization. Non-drug-administered samples wereused as a control group. The samples treated with DAP formed the study group. Molecular assays for proliferation and geneexpression were performed. The obtained data were evaluated statistically, and results with a value of p<0.05 were accepted assignificant.RESULTS: While no reduction was observed in the proliferation, the gene expression of intact intervertebral disc tissue cells wastime-dependently decreased compared to the control group, and these results were reported to be statistically significant.CONCLUSION: This study observed the effect that a pharmaceutical preparation, which was used on intervertebral disc tissuebefore and after the operation, had on normal, healthy, and intact tissue. It concludes that alterations in the expression of genesinvolved in the anabolic and/or catabolic process, even in adjacent healthy tissue, may slow down the healing process of thedamaged tissue or cause undesired cell differentiation.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAPLAN N, Yılmaz İ, KARAARSLAN N, SIRIN D, SIMSEK A, CALISKAN T, BİRCAN R, özbek h (2019). Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. , 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
Chicago	KAPLAN Necati,Yılmaz İbrahim,KARAARSLAN Numan,SIRIN Duygu YASAR,SIMSEK Abdullah Talha,CALISKAN Tezcan,BİRCAN Rifat,özbek hanefi Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. (2019): 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
MLA	KAPLAN Necati,Yılmaz İbrahim,KARAARSLAN Numan,SIRIN Duygu YASAR,SIMSEK Abdullah Talha,CALISKAN Tezcan,BİRCAN Rifat,özbek hanefi Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. , 2019, ss.522 - 529. 10.5137/1019-5149.JTN.24447-18.3
AMA	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. . 2019; 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
Vancouver	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. . 2019; 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
IEEE	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h "Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue." , ss.522 - 529, 2019. 10.5137/1019-5149.JTN.24447-18.3
ISNAD	KAPLAN, Necati vd. "Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue". (2019), 522-529. https://doi.org/10.5137/1019-5149.JTN.24447-18.3

APA	KAPLAN N, Yılmaz İ, KARAARSLAN N, SIRIN D, SIMSEK A, CALISKAN T, BİRCAN R, özbek h (2019). Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. Turkish Neurosurgery, 29(4), 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
Chicago	KAPLAN Necati,Yılmaz İbrahim,KARAARSLAN Numan,SIRIN Duygu YASAR,SIMSEK Abdullah Talha,CALISKAN Tezcan,BİRCAN Rifat,özbek hanefi Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. Turkish Neurosurgery 29, no.4 (2019): 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
MLA	KAPLAN Necati,Yılmaz İbrahim,KARAARSLAN Numan,SIRIN Duygu YASAR,SIMSEK Abdullah Talha,CALISKAN Tezcan,BİRCAN Rifat,özbek hanefi Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. Turkish Neurosurgery, vol.29, no.4, 2019, ss.522 - 529. 10.5137/1019-5149.JTN.24447-18.3
AMA	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. Turkish Neurosurgery. 2019; 29(4): 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
Vancouver	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue. Turkish Neurosurgery. 2019; 29(4): 522 - 529. 10.5137/1019-5149.JTN.24447-18.3
IEEE	KAPLAN N,Yılmaz İ,KARAARSLAN N,SIRIN D,SIMSEK A,CALISKAN T,BİRCAN R,özbek h "Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue." Turkish Neurosurgery, 29, ss.522 - 529, 2019. 10.5137/1019-5149.JTN.24447-18.3
ISNAD	KAPLAN, Necati vd. "Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue". Turkish Neurosurgery 29/4 (2019), 522-529. https://doi.org/10.5137/1019-5149.JTN.24447-18.3