Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients

Chen, Xuan; WEN, Xue; CHENG, Xiaoping

doi:10.5137/1019-5149.JTN.21840-17.4

Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients

Xue WEN, (Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan 432000, China)

Xuan CHEN, (Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan 432000, China)

Xiaoping CHENG (Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan 432000, China)

Turkish Neurosurgery

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Yıl: 2020 Cilt: 30 Sayı: 1 Sayfa Aralığı: 11 - 16 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.21840-17.4 İndeks Tarihi: 11-11-2020

Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients

Öz:

AIM: To evaluate the over expression of Glucose-regulated protein 78 kda (GRP78) in recurrent glioblastoma multiforme (GBM) andexplore its chemoresatance.MATERIAL and METHODS: Western blot analysis and real-time PCR were done to detect the expression of GRP78 in GBM tissues.RESULTS: It was detected that GRP78 is up-expressed in GBM, especially in recurrent GBM. Radiotherapy (RT) plus temozolomidechemotherapy after primary tumor removal in relapsed patients induces C/EBP homologous protein (CHOP).CONCLUSION: The results mentioned above illustrate an essential function of GRP78 in the pathogenesis of GBM and suggestthis receptor as the latest prognostic marker for further GRP78-targeted molecular cancer therapy and potential diagnosis of GMB.

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APA	WEN X, Chen X, CHENG X (2020). Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. , 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
Chicago	WEN Xue,Chen Xuan,CHENG Xiaoping Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. (2020): 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
MLA	WEN Xue,Chen Xuan,CHENG Xiaoping Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. , 2020, ss.11 - 16. 10.5137/1019-5149.JTN.21840-17.4
AMA	WEN X,Chen X,CHENG X Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. . 2020; 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
Vancouver	WEN X,Chen X,CHENG X Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. . 2020; 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
IEEE	WEN X,Chen X,CHENG X "Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients." , ss.11 - 16, 2020. 10.5137/1019-5149.JTN.21840-17.4
ISNAD	WEN, Xue vd. "Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients". (2020), 11-16. https://doi.org/10.5137/1019-5149.JTN.21840-17.4

APA	WEN X, Chen X, CHENG X (2020). Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. Turkish Neurosurgery, 30(1), 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
Chicago	WEN Xue,Chen Xuan,CHENG Xiaoping Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. Turkish Neurosurgery 30, no.1 (2020): 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
MLA	WEN Xue,Chen Xuan,CHENG Xiaoping Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. Turkish Neurosurgery, vol.30, no.1, 2020, ss.11 - 16. 10.5137/1019-5149.JTN.21840-17.4
AMA	WEN X,Chen X,CHENG X Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. Turkish Neurosurgery. 2020; 30(1): 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
Vancouver	WEN X,Chen X,CHENG X Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients. Turkish Neurosurgery. 2020; 30(1): 11 - 16. 10.5137/1019-5149.JTN.21840-17.4
IEEE	WEN X,Chen X,CHENG X "Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients." Turkish Neurosurgery, 30, ss.11 - 16, 2020. 10.5137/1019-5149.JTN.21840-17.4
ISNAD	WEN, Xue vd. "Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients". Turkish Neurosurgery 30/1 (2020), 11-16. https://doi.org/10.5137/1019-5149.JTN.21840-17.4