Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI

EKSI, Murat Sakir; EKSI, Emel Ece OZCAN; Konya, Deniz; Gungor, Abuzer; ŞİRİNOĞLU, Hakan; ALGIN, Oktay; ERBIL, Sertac; ARSLANHAN, Ayça

doi:10.5137/1019-5149.JTN.25595-18.2

Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI

Murat Sakir EKSI, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıp Fakültesi, Nöroşirurji Anabilim Dalı, İstanbul, Türkiye)

Emel Ece OZCAN EKSI, (Bahçeşehir Üniversitesi, Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Ayça ARSLANHAN, (Marmara Üniversitesi, Nörolojik Bilimler Enstitüsü, İstanbul, Türkiye)

Hakan ŞİRİNOĞLU, (Dr.Lütfü Kırdar Kartal Eğitim ve Araştırma Hastanesi, Plastik ve Rekonstrüktif Cerrahi Kliniği, İstanbul, Türkiye)

Sertac ERBIL, (Marmara Üniversitesi, Nörolojik Bilimler Enstitüsü, İstanbul, Türkiye)

Abuzer GÜNGÖR, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıp Fakültesi, Nöroşirurji Anabilim Dalı, İstanbul, Türkiye)

Oktay ALGIN, (Yıldırım Beyazıt Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi, Radyoloji Bölümü, Ankara, Türkiye)

Deniz KONYA (Bahçeşehir Üniversitesi, Tıp Fakültesi Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Turkish Neurosurgery

2 0

Yıl: 2020 Cilt: 30 Sayı: 1 Sayfa Aralığı: 17 - 22 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.25595-18.2 İndeks Tarihi: 11-11-2020

Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI

Öz:

AIM: To learn how rat primary somatosensory cortex (pSSC) responses to the loss of inputs from hind-paw, using fMRI of an inferiormagnetic power (1.5 Tesla) with special designed high-powered rat coil.MATERIAL and METHODS: Ten adult male Sprague-Dawley rats were enrolled in this study. The rats were anesthetized withketamine injection. Xylazine was intraperitoneally injected for analgesia and muscle relaxation with careful maintenance ofspontaneous respiration. Either right or left hind-paws were amputated under aseptic conditions according to predefined randomallocation of the rats. A 12-channel rat surface coil developed for proper image resolution in 1.5 Tesla MR was used. Functionalmagnetic resonance imaging was obtained before hind-paw amputation; 2, 15 and 30 days after the amputation.RESULTS: Activation signals were detected in 5 rats’ contralateral pSSC before the hind-paw amputation with regression andcessation of the signal after the amputation. Signal re-appeared in the contralateral pSSC of only one rat (rat 9) 30 days after theamputation.CONCLUSION: This study showed that functional plasticity might occur in the pSSC following hind-paw amputation of rats.Further studies are necessary to understand the true nature of the plasticity observed in pSSC, with new and novel measurementtechniques on cellular basis rather than gross anatomical one.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EKSI M, EKSI E, ARSLANHAN A, ŞİRİNOĞLU H, ERBIL S, Gungor A, ALGIN O, Konya D (2020). Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. , 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
Chicago	EKSI Murat Sakir,EKSI Emel Ece OZCAN,ARSLANHAN Ayça,ŞİRİNOĞLU Hakan,ERBIL Sertac,Gungor Abuzer,ALGIN Oktay,Konya Deniz Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. (2020): 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
MLA	EKSI Murat Sakir,EKSI Emel Ece OZCAN,ARSLANHAN Ayça,ŞİRİNOĞLU Hakan,ERBIL Sertac,Gungor Abuzer,ALGIN Oktay,Konya Deniz Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. , 2020, ss.17 - 22. 10.5137/1019-5149.JTN.25595-18.2
AMA	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. . 2020; 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
Vancouver	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. . 2020; 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
IEEE	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D "Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI." , ss.17 - 22, 2020. 10.5137/1019-5149.JTN.25595-18.2
ISNAD	EKSI, Murat Sakir vd. "Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI". (2020), 17-22. https://doi.org/10.5137/1019-5149.JTN.25595-18.2

APA	EKSI M, EKSI E, ARSLANHAN A, ŞİRİNOĞLU H, ERBIL S, Gungor A, ALGIN O, Konya D (2020). Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. Turkish Neurosurgery, 30(1), 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
Chicago	EKSI Murat Sakir,EKSI Emel Ece OZCAN,ARSLANHAN Ayça,ŞİRİNOĞLU Hakan,ERBIL Sertac,Gungor Abuzer,ALGIN Oktay,Konya Deniz Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. Turkish Neurosurgery 30, no.1 (2020): 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
MLA	EKSI Murat Sakir,EKSI Emel Ece OZCAN,ARSLANHAN Ayça,ŞİRİNOĞLU Hakan,ERBIL Sertac,Gungor Abuzer,ALGIN Oktay,Konya Deniz Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. Turkish Neurosurgery, vol.30, no.1, 2020, ss.17 - 22. 10.5137/1019-5149.JTN.25595-18.2
AMA	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. Turkish Neurosurgery. 2020; 30(1): 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
Vancouver	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI. Turkish Neurosurgery. 2020; 30(1): 17 - 22. 10.5137/1019-5149.JTN.25595-18.2
IEEE	EKSI M,EKSI E,ARSLANHAN A,ŞİRİNOĞLU H,ERBIL S,Gungor A,ALGIN O,Konya D "Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI." Turkish Neurosurgery, 30, ss.17 - 22, 2020. 10.5137/1019-5149.JTN.25595-18.2
ISNAD	EKSI, Murat Sakir vd. "Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI". Turkish Neurosurgery 30/1 (2020), 17-22. https://doi.org/10.5137/1019-5149.JTN.25595-18.2