Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats

OKTEM, Ibrahim Suat; TUMKAYA, Levent; MERCANTEPE, Tolga; Koksal, Vaner

doi:10.5137/1019-5149.JTN.27544-19.2

Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats

Vaner KÖKSAL, (Sağlık Bilimleri Üniversitesi, Samsun Sağlık Uygulama ve Araştırma Merkezi, Nöroşirurji Anabilim Dalı, Samsun, Türkiye)

Tolga MERCANTEPE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Rize, Türkiye)

Levent TÜMKAYA, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Rize, Türkiye)

Ibrahim Suat OKTEM (Erciyes Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Kayseri, Türkiye)

Turkish Neurosurgery

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Yıl: 2020 Cilt: 30 Sayı: 2 Sayfa Aralığı: 217 - 224 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.27544-19.2 İndeks Tarihi: 11-11-2020

Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats

Öz:

AIM: To investigate the role of bipolar electrocautery in the occurrence of epidural fibrosis following lumbar spine laminectomy ina rat model.MATERIAL and METHODS: Fourteen male Sprague–Dawley rats (age: 4–6 months, weight: 250–300 g) were randomly dividedinto two groups, a bipolar group (Group I) and a control group (Group II). Laminectomy was performed between the L1 and L3levels. In Group I (n=7), a laminectomy was carried out and soft tissue around the spinal cord was coagulated by using a bipolarelectrocautery. In the control group (n=7), only laminectomy was performed. The animals were sacrificed 4 weeks after surgery, andpost-laminectomy epidural fibrosis (PLEF) was evaluated. Macropathological, qualitative and quantitative histological evaluationsas well as immunohistochemical staining including transforming growth factor-β (TGF-β), collagen I and collagen III were performed.RESULTS: The numbers of TGF-β positive cells staining (PCS) were 3.00 ± 0.46 for Group I and 1.00 ± 0.52 for Group II. Thenumbers of collagen I PCS were 2.00 ± 0.93 for Group I and 1.25 ± 0.46 for Group II. The numbers of collagen III PCS were 2.25± 0.76 for Group I, 1.25 ± 0.46 for Group II, and TGF-β PCS than Group II (p≤0.05). Compared with the control group, Group I’sformation of epidural fibrosis was significantly increased.CONCLUSION: Our study clearly demonstrated that the use of bipolar cauterisation is associated with increased PLEF in theexperimental animal model. Thus, limiting the use of bipolar cauterisation may be effective in reducing this complication.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Koksal V, MERCANTEPE T, TUMKAYA L, OKTEM I (2020). Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. , 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
Chicago	Koksal Vaner,MERCANTEPE Tolga,TUMKAYA Levent,OKTEM Ibrahim Suat Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. (2020): 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
MLA	Koksal Vaner,MERCANTEPE Tolga,TUMKAYA Levent,OKTEM Ibrahim Suat Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. , 2020, ss.217 - 224. 10.5137/1019-5149.JTN.27544-19.2
AMA	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. . 2020; 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
Vancouver	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. . 2020; 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
IEEE	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I "Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats." , ss.217 - 224, 2020. 10.5137/1019-5149.JTN.27544-19.2
ISNAD	Koksal, Vaner vd. "Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats". (2020), 217-224. https://doi.org/10.5137/1019-5149.JTN.27544-19.2

APA	Koksal V, MERCANTEPE T, TUMKAYA L, OKTEM I (2020). Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. Turkish Neurosurgery, 30(2), 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
Chicago	Koksal Vaner,MERCANTEPE Tolga,TUMKAYA Levent,OKTEM Ibrahim Suat Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. Turkish Neurosurgery 30, no.2 (2020): 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
MLA	Koksal Vaner,MERCANTEPE Tolga,TUMKAYA Levent,OKTEM Ibrahim Suat Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. Turkish Neurosurgery, vol.30, no.2, 2020, ss.217 - 224. 10.5137/1019-5149.JTN.27544-19.2
AMA	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. Turkish Neurosurgery. 2020; 30(2): 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
Vancouver	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats. Turkish Neurosurgery. 2020; 30(2): 217 - 224. 10.5137/1019-5149.JTN.27544-19.2
IEEE	Koksal V,MERCANTEPE T,TUMKAYA L,OKTEM I "Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats." Turkish Neurosurgery, 30, ss.217 - 224, 2020. 10.5137/1019-5149.JTN.27544-19.2
ISNAD	Koksal, Vaner vd. "Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats". Turkish Neurosurgery 30/2 (2020), 217-224. https://doi.org/10.5137/1019-5149.JTN.27544-19.2