Does melatonin alleviate ototoxic effect caused by administration of cisplatin?

caliskan, murat; Ozel, Gokce; Besalti, Omer; Vuralkan, Erkan; akin, istemihan; Alicura Tokgoz, Sibel

doi:10.5455/annalsmedres.2019.08.485

Does melatonin alleviate ototoxic effect caused by administration of cisplatin?

Sibel ALICURA TOKGÖZ, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Gökce ŞİMŞEK, (Kırıkkale Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Kırıkkale, Türkiye)

Erkan VURALKAN, (Medical Park Trabzon Yıldızlı Hastanesi, Kulak Burun Boğaz Kliniği, Trabzon, Türkiye)

Murat ÇALIŞKAN, (Ankara Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Ankara, Türkiye)

Ömer BESALTI, (Sağlık Bilimleri Üniversitesi, Dışkapı Yıdırım Beyazıt Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Istemihan AKIN (Sağlık Bilimleri Üniversitesi, Dışkapı Yıdırım Beyazıt Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Annals of Medical Research

7 1

Yıl: 2019 Cilt: 26 Sayı: 11 Sayfa Aralığı: 2604 - 2608 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.08.485 İndeks Tarihi: 24-09-2020

Does melatonin alleviate ototoxic effect caused by administration of cisplatin?

Öz:

Aim: In this study, it was aimed to experimentally investigate the protective effects of melatonin in the cisplatin-induced ototoxicity.Material and Methods: Ten Wistar-albino rats were included in the study. Two equal groups were generated randomly as cisplatinand melatonin groups. Rats’ underwent Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emission (DPOAE)testing before the drug administration and the results were recorded. Both tests were repeated 72 hours after the cisplatinadministration in all rats.Results: Significant difference was found between the I-IV interval values before the treatment and after the treatment both incisplatin and melatonin group. As well as the significant difference in hearing threshold value changes, statistically, significantdifferences in ABR-I and ABR-IV interval variations were also seen between the cisplatin and melatonin groups. A statisticallysignificant decrease was found between the initial and final control SNR (signal-to-noise ratio) levels within the cisplatin group inthe evaluations at 2000Hz, 3000Hz and 4000Hz. Statistically, significant differences were observed between SNR levels when themelatonin group was compared with the cisplatin group.Conclusion: Melatonin appears to reduce cisplatin-induced ototoxicity in rats. Although, the use of supplementary therapies targetingto reduce the toxic effects in clinical studies is still a controversial point.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Alicura Tokgoz S, Ozel G, Vuralkan E, caliskan m, Besalti O, akin i (2019). Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. , 2604 - 2608. 10.5455/annalsmedres.2019.08.485
Chicago	Alicura Tokgoz Sibel,Ozel Gokce,Vuralkan Erkan,caliskan murat,Besalti Omer,akin istemihan Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. (2019): 2604 - 2608. 10.5455/annalsmedres.2019.08.485
MLA	Alicura Tokgoz Sibel,Ozel Gokce,Vuralkan Erkan,caliskan murat,Besalti Omer,akin istemihan Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. , 2019, ss.2604 - 2608. 10.5455/annalsmedres.2019.08.485
AMA	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. . 2019; 2604 - 2608. 10.5455/annalsmedres.2019.08.485
Vancouver	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. . 2019; 2604 - 2608. 10.5455/annalsmedres.2019.08.485
IEEE	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i "Does melatonin alleviate ototoxic effect caused by administration of cisplatin?." , ss.2604 - 2608, 2019. 10.5455/annalsmedres.2019.08.485
ISNAD	Alicura Tokgoz, Sibel vd. "Does melatonin alleviate ototoxic effect caused by administration of cisplatin?". (2019), 2604-2608. https://doi.org/10.5455/annalsmedres.2019.08.485

APA	Alicura Tokgoz S, Ozel G, Vuralkan E, caliskan m, Besalti O, akin i (2019). Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. Annals of Medical Research, 26(11), 2604 - 2608. 10.5455/annalsmedres.2019.08.485
Chicago	Alicura Tokgoz Sibel,Ozel Gokce,Vuralkan Erkan,caliskan murat,Besalti Omer,akin istemihan Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. Annals of Medical Research 26, no.11 (2019): 2604 - 2608. 10.5455/annalsmedres.2019.08.485
MLA	Alicura Tokgoz Sibel,Ozel Gokce,Vuralkan Erkan,caliskan murat,Besalti Omer,akin istemihan Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. Annals of Medical Research, vol.26, no.11, 2019, ss.2604 - 2608. 10.5455/annalsmedres.2019.08.485
AMA	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. Annals of Medical Research. 2019; 26(11): 2604 - 2608. 10.5455/annalsmedres.2019.08.485
Vancouver	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i Does melatonin alleviate ototoxic effect caused by administration of cisplatin?. Annals of Medical Research. 2019; 26(11): 2604 - 2608. 10.5455/annalsmedres.2019.08.485
IEEE	Alicura Tokgoz S,Ozel G,Vuralkan E,caliskan m,Besalti O,akin i "Does melatonin alleviate ototoxic effect caused by administration of cisplatin?." Annals of Medical Research, 26, ss.2604 - 2608, 2019. 10.5455/annalsmedres.2019.08.485
ISNAD	Alicura Tokgoz, Sibel vd. "Does melatonin alleviate ototoxic effect caused by administration of cisplatin?". Annals of Medical Research 26/11 (2019), 2604-2608. https://doi.org/10.5455/annalsmedres.2019.08.485