Yıl: 2020 Cilt: 57 Sayı: 2 Sayfa Aralığı: 154 - 159 Metin Dili: Türkçe DOI: 10.29399/npa.26148 İndeks Tarihi: 02-10-2020

Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar

Öz:
Bazı solunum yolu virüslerinin nörolojik tutulum yapabildiği uzunyıllardır bilinmektedir. Ne yazık ki, Aralık 2019’da ortaya çıkan ve akut ağırsolunum yetersizliği sendromuna yol açan yeni tip koronavirüs 2 (SARSCoV-2), diğer adıyla koronavirüs hastalığı 19 (COVID-19) ile artık nörolojikenvazyon potansiyeli olan virüsler grubuna yeni bir üyenin katıldığıgörülmektedir. Önüne geçilemeyen bir hızla tüm dünyada yayılmayadevam eden ve şimdiden milyonlarca insanı enfekte eden SARSCoV-2 ile ilişkili nörolojik semptom ve bulgulara gün geçtikçe yenilerieklenmektedir. Başağrısı, “dizziness”, bilinç bulanıklığı, ataksi, epilepsi,iskemik inme, nöropatik ağrı ve miyopatinin özellikle enfeksiyonun ağırseyrettiği olgularda daha sık olarak görüldüğü bildirilmektedir. Ayrıcaikincil nörolojik semptom gelişmesinin kötü sonlanım ile ilişkili olduğuda ifade edilmektedir. Öte yandan, çok sayıda SARS-CoV-2 taşıyıcısındaise tek semptomun koku duyusunda azalma olduğu ve bu semptomunhastalık belirteci olarak kabul edilebileceği ileri sürülmüştür. Kısacasıhafif semptomu olan ya da hastalığın ağır seyrettiği geniş spektrumda,SARS-CoV-2’nin direkt ve dolaylı mekanizmalar aracılığıyla bu nörolojiksemptomlara yol açabileceği düşünülmektedir. Bununla birlikte, birensefalit hastasının beyin omurilik sıvısında virüsün gen sekanslamasıile gösterilebilmesinin ardından, virüsün nöro-envazyon yapabildiğineve merkezi sinir sistemini enfekte edebildiğine yüksek olasılık olarakbakılmaya başlanmıştır. Sonuçta, salgının yükselme dönemini yaşamaktaolduğumuz dönemde, pandemi süresince en fazla karşılaşacağımızhastalığın olası nörolojik bulguları ile ilgili bilgi sahibi olmak değerlidir.Bu amaçla, literatürde SARS-CoV-2 ile ilişkilendirilmiş nörolojik tablolaraek olarak, yeni koronavirüsün yüksek oranda homoloji gösterdiği SARSCoV veya Ortadoğu solunum sendromu (MERS)-CoV gibi insandaenfeksiyona yol açan diğer koronavirüslere ilişkin literatürün de gözdengeçirilmesi ve salgının uzun dönem komplikasyonlarıyla ilgili fikir sahibiolunması amaçlanmıştır
Anahtar Kelime:

Coronavirus Disease 2019 (COVID-19) From the Point of View of Neurologists: Observation of Neurological Findings and Symptoms During the Combat Against a Pandemic

Öz:
Some respiratory viruses have long been known to cause neurological involvement. A novel coronavirus, leading to severe acute respiratory syndrome, also called coronavirus disease 19 (COVID-19), seems to be a new member of neuroinvasive viruses. While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps on spreading around the world rapidly, reports about the neurological manifestations associated with SARS-CoV-2, increases day by day. It is reported that a variety of symptoms and syndromes such as headache, dizziness, confusion, ataxia, epilepsy, ischemic stroke, neuropathic pain and myopathy are common especially in more severe COVID-19 patients. It is also suggested that the development of neurological complications is strongly associated with a poor outcome. On the other hand, hyposmia can be the unique symptom in COVID-19 carriers and this can serve as a marker for identifying the otherwise asymptomatically infected patients. It is thought that SARSCoV-2 may cause neurological symptoms through direct or indirect mechanisms. Nevertheless, neuroinvasion capability of SARS-CoV2 is confirmed by the presence of the virus, in the cerebrospinal fluid of a COVID-19 patient with encephalitis, and this is proven by gene sequencing. In conclusion, during the COVID-19 pandemic, it is crucial to be aware of the possible neurological complications of the disease. Therefore, in this review, we aimed to report neurological manifestations associated with SARS-CoV-2 and possible underlying pathophysiological mechanisms. Due to the high homology of SARS-CoV-2 with other human coronaviruses such as SARS-CoV or Middle East Respiratory Syndrome (MERS)-CoV, reviewing the neurological involvement also associated with these coronaviruses will also provide an idea about the long-term complications of COVID-19.
Anahtar Kelime:

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APA Ozdag Acarli A, Samanci B, Ekizoglu E, Cakar A, Sirin N, GÜNDÜZ T, parman y, Baykan B (2020). Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. , 154 - 159. 10.29399/npa.26148
Chicago Ozdag Acarli Ayse Nur,Samanci Bedia,Ekizoglu Esme,Cakar Arman,Sirin Nermin Gorkem,GÜNDÜZ TUNCAY,parman yesim,Baykan Betul Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. (2020): 154 - 159. 10.29399/npa.26148
MLA Ozdag Acarli Ayse Nur,Samanci Bedia,Ekizoglu Esme,Cakar Arman,Sirin Nermin Gorkem,GÜNDÜZ TUNCAY,parman yesim,Baykan Betul Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. , 2020, ss.154 - 159. 10.29399/npa.26148
AMA Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. . 2020; 154 - 159. 10.29399/npa.26148
Vancouver Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. . 2020; 154 - 159. 10.29399/npa.26148
IEEE Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B "Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar." , ss.154 - 159, 2020. 10.29399/npa.26148
ISNAD Ozdag Acarli, Ayse Nur vd. "Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar". (2020), 154-159. https://doi.org/10.29399/npa.26148
APA Ozdag Acarli A, Samanci B, Ekizoglu E, Cakar A, Sirin N, GÜNDÜZ T, parman y, Baykan B (2020). Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. Nöropsikiyatri Arşivi, 57(2), 154 - 159. 10.29399/npa.26148
Chicago Ozdag Acarli Ayse Nur,Samanci Bedia,Ekizoglu Esme,Cakar Arman,Sirin Nermin Gorkem,GÜNDÜZ TUNCAY,parman yesim,Baykan Betul Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. Nöropsikiyatri Arşivi 57, no.2 (2020): 154 - 159. 10.29399/npa.26148
MLA Ozdag Acarli Ayse Nur,Samanci Bedia,Ekizoglu Esme,Cakar Arman,Sirin Nermin Gorkem,GÜNDÜZ TUNCAY,parman yesim,Baykan Betul Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. Nöropsikiyatri Arşivi, vol.57, no.2, 2020, ss.154 - 159. 10.29399/npa.26148
AMA Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. Nöropsikiyatri Arşivi. 2020; 57(2): 154 - 159. 10.29399/npa.26148
Vancouver Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar. Nöropsikiyatri Arşivi. 2020; 57(2): 154 - 159. 10.29399/npa.26148
IEEE Ozdag Acarli A,Samanci B,Ekizoglu E,Cakar A,Sirin N,GÜNDÜZ T,parman y,Baykan B "Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar." Nöropsikiyatri Arşivi, 57, ss.154 - 159, 2020. 10.29399/npa.26148
ISNAD Ozdag Acarli, Ayse Nur vd. "Nörolog Gözüyle Koronavirüs Hastalığı 2019 (COVID-19): Pandemi ile Mücadele Sırasında Dikkat Edilmesi Gereken Nörolojik Bulgu ve Semptomlar". Nöropsikiyatri Arşivi 57/2 (2020), 154-159. https://doi.org/10.29399/npa.26148