Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease characterized by recurrent attacks of fever,usually accompanied by sterile polyserositis. Although colchicine is the main medical treatment option for FMF, potentialadverse effects and drug interactions should be considered during the follow-up of these patients. Herein, we presented acase of a hemodialysis patient with FMF, who developed rhabdomyolysis due to concomitant use of colchicine and clarithromycin for pneumonia treatment.