May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?

Aydın, Oktay; AYDINURAZ, Kuzey; KARACA, GÖKHAN; Aydın, gülcin; bulut, huri; PEHLİVANLI, Faruk; ALTUNKAYA, CANAN

doi:10.5152/tjg.2019.18697

May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?

Oktay AYDIN, (Kırıkkale Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kırıkkale, Türkiye)

Faruk PEHLİVANLI, (Kırıkkale Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kırıkkale, Türkiye)

Gökhan KARACA, (Kırıkkale Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kırıkkale, Türkiye)

Gülçin AYDIN, (Kırıkkale Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kırıkkale, Türkiye)

Canan ALTUNKAYA, (Kırıkkale Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Kırıkkale, Türkiye)

Huri BULUT, (Bezmialem Vakıf Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Kuzey AYDINURAZ (Kırıkkale Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kırıkkale, Türkiye)

Turkish Journal of Gastroenterology

8 0

Yıl: 2019 Cilt: 30 Sayı: 9 Sayfa Aralığı: 826 - 834 Metin Dili: İngilizce DOI: 10.5152/tjg.2019.18697 İndeks Tarihi: 20-07-2020

May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?

Öz:

Background/Aims: Complete liver regeneration may not always be possible after liver injuries and/or partial liver resection. The presentstudy investigated the effects of dexpanthenol, platelet-rich plasma (PRP), and thymoquinone on liver regeneration in rats after partialhepatectomy (PH).Materials and Methods: A total of 34 Wistar albino rats, each weighing 250-280 g, were randomly separated into four groups.PH was performed, and except for the control group, intraperitoneal dexpanthenol, PRP, or thymoquinone was administered tothe relevant groups for 7 days. All rats were then sacrificed, and the liver tissues were examined histopathologically and biochemically.Results: PRP reduced all oxidant-antioxidant parameters in rats that experienced liver regeneration, but did not create histopathological improvement in the liver tissue. Dexpanthenol had a histopathological improving effect on the liver tissue, but had no effect onbiochemical parameters. Thymoquinone showed no histopathological or biochemical effects on liver regeneration.Conclusion: Although dexpanthenol did not affect biochemical oxidative parameters, it was considered to have improving effects onliver regeneration histopathologically. In addition, it was thought that PRP may be used for treatment of ischemia-reperfusion injury andcholestatic damage of the liver. Nevertheless, further studies are required on these subjects.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aydın O, PEHLİVANLI F, KARACA G, Aydın g, ALTUNKAYA C, bulut h, AYDINURAZ K (2019). May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. , 826 - 834. 10.5152/tjg.2019.18697
Chicago	Aydın Oktay,PEHLİVANLI Faruk,KARACA GÖKHAN,Aydın gülcin,ALTUNKAYA CANAN,bulut huri,AYDINURAZ Kuzey May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. (2019): 826 - 834. 10.5152/tjg.2019.18697
MLA	Aydın Oktay,PEHLİVANLI Faruk,KARACA GÖKHAN,Aydın gülcin,ALTUNKAYA CANAN,bulut huri,AYDINURAZ Kuzey May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. , 2019, ss.826 - 834. 10.5152/tjg.2019.18697
AMA	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. . 2019; 826 - 834. 10.5152/tjg.2019.18697
Vancouver	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. . 2019; 826 - 834. 10.5152/tjg.2019.18697
IEEE	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K "May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?." , ss.826 - 834, 2019. 10.5152/tjg.2019.18697
ISNAD	Aydın, Oktay vd. "May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?". (2019), 826-834. https://doi.org/10.5152/tjg.2019.18697

APA	Aydın O, PEHLİVANLI F, KARACA G, Aydın g, ALTUNKAYA C, bulut h, AYDINURAZ K (2019). May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. Turkish Journal of Gastroenterology, 30(9), 826 - 834. 10.5152/tjg.2019.18697
Chicago	Aydın Oktay,PEHLİVANLI Faruk,KARACA GÖKHAN,Aydın gülcin,ALTUNKAYA CANAN,bulut huri,AYDINURAZ Kuzey May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. Turkish Journal of Gastroenterology 30, no.9 (2019): 826 - 834. 10.5152/tjg.2019.18697
MLA	Aydın Oktay,PEHLİVANLI Faruk,KARACA GÖKHAN,Aydın gülcin,ALTUNKAYA CANAN,bulut huri,AYDINURAZ Kuzey May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. Turkish Journal of Gastroenterology, vol.30, no.9, 2019, ss.826 - 834. 10.5152/tjg.2019.18697
AMA	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. Turkish Journal of Gastroenterology. 2019; 30(9): 826 - 834. 10.5152/tjg.2019.18697
Vancouver	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. Turkish Journal of Gastroenterology. 2019; 30(9): 826 - 834. 10.5152/tjg.2019.18697
IEEE	Aydın O,PEHLİVANLI F,KARACA G,Aydın g,ALTUNKAYA C,bulut h,AYDINURAZ K "May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?." Turkish Journal of Gastroenterology, 30, ss.826 - 834, 2019. 10.5152/tjg.2019.18697
ISNAD	Aydın, Oktay vd. "May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?". Turkish Journal of Gastroenterology 30/9 (2019), 826-834. https://doi.org/10.5152/tjg.2019.18697