Objective: This study aimed to evaluate the prevalence of hypoalbuminemia and hyperuricemia, and investigate uric acidalbumin ratio association with mortality and acute kidney injury (AKI) in critically ill patients.Materials and Methods: We evaluated 754 patients who were admitted to intensive care unit (ICU) between 2008 and 2014.We investigated the effects of hypoalbuminemia and uric acid / albumin ratio on mortality and AKI.Results: A total of 754 critically ill patients (52.4% male and mean age 57.1±18.7 years) were enrolled in this study. Amongthem, 72.8% (549/754) patients had hypoalbuminemia during the admission to ICU. A total of 381/754 (50.5%) patients developed AKI. The 28-day mortality rate was significantly higher in hypoalbuminemia group than in normal plasma albumingroup [35.7% (196) vs. 18.5% (38), p=0.01]. The uric acid level higher than 7 mg/dl was associated with AKI (p<0.001). Uricacid albumin ratio higher than 1.7 was significantly associated with AKI and 28-day mortality (p<0.001 and p<0.001).Conclusion: This study successfully confirmed that hypoalbuminemia in ICU admission has been independently associated with increased early death and AKI in critically ill patients; and uric acid albumin ratio could be a marker to predict AKIand mortality.