Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance

Genc, Ozlem; PAŞALI KİLİT, Türkan; ONBAŞI, Kevser; Kocak, Fatma Emel; KORKUT, Yasemin; AKSU, Evrim

doi:10.5505/TurkHijyen.2018.59013

Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance

Özlem GENÇ, (Dumlupınar Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Kütahya, Türkiye)

Evrim AKSU, (Evliya Çelebi Araştırma Ve Eğitim Hastanesi, Mikrobiyoloji Laboratuvarı, Kütahya, Türkiye)

Türkan PAŞALI KİLİT, (Dumlupınar Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kütahya, Türkiye)

Fatma Emel KOÇAK, (Dumlupınar Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kütahya, Türkiye)

Yasemin KORKUT, (Dumlupınar Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Kütahya, Türkiye)

Kevser ONBAŞI (Dumlupınar Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Kütahya, Türkiye)

Türk Hijyen ve Deneysel Biyoloji Dergisi

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Yıl: 2018 Cilt: 75 Sayı: 4 Sayfa Aralığı: 365 - 374 Metin Dili: İngilizce DOI: 10.5505/TurkHijyen.2018.59013 İndeks Tarihi: 22-07-2020

Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance

Öz:

Objective: We aimed to compare a type 2 diabeticwomen groups with a women group with impairedglucose tolerance (IGT) for the presence of urinary tractinfection (UTI) and/or asymptomatic bacteriuria (ASB)and related risk factors [age, body mass index (BMI),serum HbA1c and creatinine levels, glomerular filtrationrate (GFR), and urine microalbumin, urine leukocyte andglucose levels] associated therewith.Methods: The study population consisted of 416female patients and divided into two groups as the type2 diabetes mellitus (DM, n=208) and the IGT (n=208)group. Serum HbA1c and creatinine levels and leukocytecounts, glucose level and microalbumin level in theurine, were measured in the biochemistry laboratory.GFR was calculated using the Cockcroft-Gault formula.Urine samples were inoculated on blood agar and EosinMethylene Blue agar medium and incubated for 24-48hour at 37°C.Results: ASB was determined in 5 patients (2%) inthe DM group and in 15 patients (7%) in the IGT group.UTI was detected in 9 patients (4%) in the diabeticgroup and in 7 patients (3%) in the IGT group (p>0.05).Pyuria was found as an ASB-related risk factor in bothgroups (p<0.05). BMI (p=0.041), creatinine (p=0.045)and GFR (p=0.035) were determined as UTI-relatedrisk factors in the diabetic group. In addition, pyuriawas found as UTI-related risk factors in IGT group(p=0.019). Escherichia coli was the most prevalentpathogen (89%).Conclusion: We suggest that high BMI and creatininelevels and low GFR are risk factors for UTI in patientswith type 2 DM. Additionally this is a first study to detectthat UTI and ASB may develop in patients with IGT, justas in diabetic patients. Considering a similar frequencyof UTI and ASB in patients with IGT and with type 2 DM,urine culture may be performed in IGT patients withpyuria.

Anahtar Kelime:

Tip 2 Diyabet hastalığı ve bozulmuş glikoz toleransı olan kadınlarda asemptomatik bakteriüri ve üriner sistem enfeksiyonları

Öz:

Amaç: Çalışmamızda; tip 2 diabetes mellitusu (DM) olan ve bozulmuş glikoz toleransı (BGT) olan iki kadın hasta grubunun üriner sistem infeksiyonu (ÜSİ) ve asemptomatik bakteriüri (ASB) varlığı ve ilişkili risk faktörleri açısından karşılaştırılması amaçlandı. Risk faktörleri olarak; yaş, vücut kitle indeksi (VKİ), serum HbA1c ve kreatinin seviyeleri, glomerüler filtrasyon oranı (GFR), idrardaki lökosit sayısı, glikoz miktarı ve mikroalbumin düzeyi seçildi. Yöntem: Diyabetli 208 kadın hasta ve BGT’si olan 208 kadın hasta çalışmaya dahil edildi. Serum HbA1c ve kreatinin seviyeleri ve idrardaki lökosit sayısı, glikoz miktarı ve mikroalbumin düzeyi biyokimya laboratuvarında ölçüldü. GFR, Cockcroft-Gault formula kullanılarak hesaplandı. Hastalardan alınan orta akım idrarı mikrobiyoloji laboratuvarında kanlı agar ve EMB agara ekildi. Bulgular: Diyabetli hasta grubunda beş (%2) hastada, BGT hasta grubunda 15 (%7) hastada ASB saptandı. ÜSİ; diyabetik grupta dokuz (%4) hastada , BGT hasta grubunda yedi (%3) hastada belirlendi (p>0.05). Piyüri; her iki hasta grubunda ASB ile ilişkili risk faktörü idi (p<0.05). Diyabetli grupta; VKİ (p=0.041), kreatinin (p=0.045) ve GFR (p=0.035) ÜSİ ilişkili risk faktörü olarak saptandı. BGT hasta grubunda ise sadece piyüri; ÜSİ ile ilişkili (p=0.019) risk faktörü olarak belirlendi. Hem ASB’si olan hem de ÜSİ olan hastalarda en fazla Escherichia coli izole edildi (%89). Sonuç: Yüksek VKİ ve serum kreatinin seviyesi ve düşük GFR’nin tip 2 diyabetes mellitusu olan hastalarda ÜSİ gelişimi açısından risk faktörü olduğunu düşünmekteyiz. Ayrıca bu çalışma; BGT olan hastalarda da hem ASB hem de ÜSİ gelişme riskinin diyabetli hastalar ile aynı olduğunu gösteren ilk çalışmadır. Her iki hasta grubunda ASB ve ÜSİ oranının benzer olduğu düşünülürse, özellikle pyüri saptanan BGT’si olan hastalarda da idrar kültürü yapılmasını önermekteyiz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Genc O, AKSU E, PAŞALI KİLİT T, Kocak F, KORKUT Y, ONBAŞI K (2018). Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. , 365 - 374. 10.5505/TurkHijyen.2018.59013
Chicago	Genc Ozlem,AKSU Evrim,PAŞALI KİLİT Türkan,Kocak Fatma Emel,KORKUT Yasemin,ONBAŞI Kevser Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. (2018): 365 - 374. 10.5505/TurkHijyen.2018.59013
MLA	Genc Ozlem,AKSU Evrim,PAŞALI KİLİT Türkan,Kocak Fatma Emel,KORKUT Yasemin,ONBAŞI Kevser Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. , 2018, ss.365 - 374. 10.5505/TurkHijyen.2018.59013
AMA	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. . 2018; 365 - 374. 10.5505/TurkHijyen.2018.59013
Vancouver	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. . 2018; 365 - 374. 10.5505/TurkHijyen.2018.59013
IEEE	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K "Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance." , ss.365 - 374, 2018. 10.5505/TurkHijyen.2018.59013
ISNAD	Genc, Ozlem vd. "Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance". (2018), 365-374. https://doi.org/10.5505/TurkHijyen.2018.59013

APA	Genc O, AKSU E, PAŞALI KİLİT T, Kocak F, KORKUT Y, ONBAŞI K (2018). Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. Türk Hijyen ve Deneysel Biyoloji Dergisi, 75(4), 365 - 374. 10.5505/TurkHijyen.2018.59013
Chicago	Genc Ozlem,AKSU Evrim,PAŞALI KİLİT Türkan,Kocak Fatma Emel,KORKUT Yasemin,ONBAŞI Kevser Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. Türk Hijyen ve Deneysel Biyoloji Dergisi 75, no.4 (2018): 365 - 374. 10.5505/TurkHijyen.2018.59013
MLA	Genc Ozlem,AKSU Evrim,PAŞALI KİLİT Türkan,Kocak Fatma Emel,KORKUT Yasemin,ONBAŞI Kevser Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. Türk Hijyen ve Deneysel Biyoloji Dergisi, vol.75, no.4, 2018, ss.365 - 374. 10.5505/TurkHijyen.2018.59013
AMA	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2018; 75(4): 365 - 374. 10.5505/TurkHijyen.2018.59013
Vancouver	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2018; 75(4): 365 - 374. 10.5505/TurkHijyen.2018.59013
IEEE	Genc O,AKSU E,PAŞALI KİLİT T,Kocak F,KORKUT Y,ONBAŞI K "Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance." Türk Hijyen ve Deneysel Biyoloji Dergisi, 75, ss.365 - 374, 2018. 10.5505/TurkHijyen.2018.59013
ISNAD	Genc, Ozlem vd. "Asymptomatic bacteriuria, urinary tract infection and risk factors in women with type 2 diabetes mellitus and impaired glucose tolerance". Türk Hijyen ve Deneysel Biyoloji Dergisi 75/4 (2018), 365-374. https://doi.org/10.5505/TurkHijyen.2018.59013