Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?
Yıl: 2020 Cilt: 26 Sayı: 4 Sayfa Aralığı: 580 - 585 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.34412 İndeks Tarihi: 21-10-2020
Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?
Öz: BACKGROUND: This study aims to demonstrate the sensitivity and specificity of C-reactive protein to plasma albumin (CRP/ALB)ratio in predicting morbidity and mortality in patients operated for colorectal cancer followed up in the intensive care unit by comparingit with current scoring systems.METHODS: The data of patients who underwent surgery for colorectal cancer and hospitalized in the intensive care unit between2015–2018 with available data were retrospectively analyzed in this study. The CRP/ALB ratio, the physiological and operative severityscore for the enumeration of mortality and morbidity (POSSUM) prepared for both gastrointestinal and colorectal surgery, and theAssociation of Coloproctology of Great Britain and Ireland (ACPGBI-CRC) scoring system prepared for colorectal patients, werecompared to determine their success in predicting mortality and morbidity.RESULTS: A total of 119 patients were included in this study. Mortality was observed in nine patients and morbidity was observed in38 patients. When compared with P-POSSUM, which is the only scoring system showing morbidity, the CRP/ALB ratio was found tohave a high prediction accuracy. The C reactive protein to plasma albumin ratio values was found to have lower power than P-POSSUM,CR-POSSUM and ACPGBI-CRC.CONCLUSION: Although scoring systems are useful in predicting morbidity and mortality in colorectal patients, they are difficultto use in practice since they include many parameters. that the findings obtained in this study suggest that the CRP/ALB ratio, whichcan be calculated without any additional cost, may help the clinician predict mortality and especially morbidity.
Anahtar Kelime: Kolorektal kanserli hastalarda C-reaktif protein ve plazma albumin seviyesinin oranı mortalite ve morbiditeyi göstermede alternatif bir skorlama olabilir mi?
Öz: AMAÇ: Bu çalışmada, kolorektal kanser nedeniyle ameliyat edilen ve yoğun bakımda takip edilen hastalarda, C-reaktif proteinin plazma albüminine oranının (CRP/ALB), güncel skorlama sistemleri ile karşılaştırılarak, morbidite ve mortaliteyi ön görmedeki sensitivite ve spesifitesini ortaya koymak amaçlanmıştır. GEREÇ VE YÖNTEM: Kliniğimizde 2015–2018 yılları arasında verilerine ulaşılabilen kolorektal kanser nedeniyle ameliyat olan ve yoğun bakımda yatan hastaların verileri geriye dönük incelendi. CRP/ALB, hem gastrointestinal hemde kolorektal cerrahi için hazırlanan, physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) ve kolorektal hastalar için hazırlanan “Association of Coloproctology of Great Britain and Ireland” (ACPGBI-CRC) skorlama sistemlerinin mortalite ve morbidite ön görmedeki başarıları karşılaştırıldı. BULGULAR: Toplam 119 hasta çalışmada değerlendirilmeye alındı. Hastaların dokuzunda mortalite, 38’inde morbidite olduğu görüldü. Morbiditeyi gösteren tek skorlama sistemi olan P-POSSUM ile kıyaslandığında CRP/ALB oranının daha yüksek bir doğrulukla ön görüsü olduğu bulundu. Mortaliteyi göstermede, CRP/ALB değerinin P-POSSUM, CR-POSSUM ve ACPGBI-CRC’ye oranla daha zayıf olduğu tespit edildi. TARTIŞMA: Skorlama sistemleri kolorektal hastalarda morbidite ve mortaliteyi tahmin etmede kullanışlı olsa dahi pratikte çok fazla parametre içerdikleri için kullanımları zordur. Bu çalışmanın sonuçlarına göre, ek maliyet getirmeden hesaplanabilecek CRP/ALB oranının mortalite ve özellikle morbiditeyi tahmin etmede klinisyene yardımcı olabileceğini düşünüyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Hendren S, Birkmeyer JD, Yin H, Banerjee M, Sonnenday C, Morris AM. Surgical complications are associated with omission of chemotherapy for stage III colorectal cancer. Dis Colon Rectum 2010;53:1587−93.
- 2. Jones HJ, de Cossart L. Risk scoring in surgical patients. Br J Surg 1999;86:149−57.
- 3. Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br J Surg 1991;78:355−60.
- 4. Tekkis PP, McCulloch P, Poloniecki JD, Prytherch DR, Kessaris N, Steger AC. Risk-adjusted prediction of operative mortality in oesophagogastric surgery with O-POSSUM. Br J Surg 2004;91:288−95.
- 5. Tekkis PP, Prytherch DR, Kocher HM, Senapati A, Poloniecki JD, Stamatakis JD, et al. Development of a dedicated risk-adjustment scoring system for colorectal surgery (colorectal POSSUM). Br J Surg 2004;91:1174−82.
- 6. Leung E, McArdle K, Wong LS. Risk-adjusted scoring systems in colorectal surgery. Int J Surg 2011;9:130−5.
- 7. Al-Homoud S, Purkayastha S, Aziz O, Smith JJ, Thompson MD, Darzi AW, et al. Evaluating operative risk in colorectal cancer surgery: ASA and POSSUM-based predictive models. Surg Oncol 2004;13:83−92.
- 8. Park JE, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, et al. The CReactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients. J Clin Med 2018;7:333.
- 9. Nehring SM, Goyal A, Bansal P, Patel BC. C Reactive Protein (CRP). Treasure Island. FL: StatPearls; 2018.
- 10. Shalaby M, Di Lorenzo N, Franceschilli L, Perrone F, Angelucci GP, Quareisma S, et al. Outcome of Colorectal Surgery in Elderly Populations. Ann Coloproctol 2016;32:139−43.
- 11. Prytherch DR, Whiteley MS, Higgins B, Weaver PC, Prout WG, Powell SJ. POSSUM and Portsmouth POSSUM for predicting mortality. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity. Br J Surg 1998;85:1217−20.
- 12. Tekkis PP, Poloniecki JD, Thompson MR, Stamatakis JD. Operative mortality in colorectal cancer: prospective national study. BMJ 2003;327:1196−201.
- 13. Oh TK, Ji E, Na HS, Min B, Jeon YT, Do SH, et al. C-Reactive Protein to Albumin Ratio Predicts 30-Day and 1-Year Mortality in Postoperative Patients after Admission to the Intensive Care Unit. J Clin Med 2018;7:39.
- 14. Wang F, Li P, Li FS. Prognostic role of C-reactive protein to albumin ratio in colorectal cancer: A meta analysis. Medicine (Baltimore) 2019;98:e16064.
- 15. Yan J, Wang YX, Li ZP. Predictive value of the POSSUM, p-POSSUM, cr-POSSUM, APACHE II and ACPGBI scoring systems in colorectal cancer resection. J Int Med Res 2011;39:1464−73.
| APA | Şahiner Y, YILDIRIM M (2020). Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. , 580 - 585. 10.14744/tjtes.2020.34412 |
| Chicago | Şahiner Yeliz,YILDIRIM Murat Baki Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. (2020): 580 - 585. 10.14744/tjtes.2020.34412 |
| MLA | Şahiner Yeliz,YILDIRIM Murat Baki Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. , 2020, ss.580 - 585. 10.14744/tjtes.2020.34412 |
| AMA | Şahiner Y,YILDIRIM M Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. . 2020; 580 - 585. 10.14744/tjtes.2020.34412 |
| Vancouver | Şahiner Y,YILDIRIM M Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. . 2020; 580 - 585. 10.14744/tjtes.2020.34412 |
| IEEE | Şahiner Y,YILDIRIM M "Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?." , ss.580 - 585, 2020. 10.14744/tjtes.2020.34412 |
| ISNAD | Şahiner, Yeliz - YILDIRIM, Murat Baki. "Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?". (2020), 580-585. https://doi.org/10.14744/tjtes.2020.34412 |
| APA | Şahiner Y, YILDIRIM M (2020). Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. Ulusal Travma ve Acil Cerrahi Dergisi, 26(4), 580 - 585. 10.14744/tjtes.2020.34412 |
| Chicago | Şahiner Yeliz,YILDIRIM Murat Baki Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.4 (2020): 580 - 585. 10.14744/tjtes.2020.34412 |
| MLA | Şahiner Yeliz,YILDIRIM Murat Baki Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.4, 2020, ss.580 - 585. 10.14744/tjtes.2020.34412 |
| AMA | Şahiner Y,YILDIRIM M Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 580 - 585. 10.14744/tjtes.2020.34412 |
| Vancouver | Şahiner Y,YILDIRIM M Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(4): 580 - 585. 10.14744/tjtes.2020.34412 |
| IEEE | Şahiner Y,YILDIRIM M "Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.580 - 585, 2020. 10.14744/tjtes.2020.34412 |
| ISNAD | Şahiner, Yeliz - YILDIRIM, Murat Baki. "Can the C-reactive protein-to-plasma albumin ratio be an alternative scoring to show mortality and morbidity in patients with colorectal cancer?". Ulusal Travma ve Acil Cerrahi Dergisi 26/4 (2020), 580-585. https://doi.org/10.14744/tjtes.2020.34412 |
