Objective: The aim of our study was to evaluate apical root resorption and changes in tooth inclinations, marginal bone height, andlabio-lingual bone thickness at the mid-root and apical level in mandibular anterior teeth during the Forsus treatment using conebeam computed tomography (CBCT).Methods: CBCT scans of 16 subjects (8 males and 8 females) with Class II malocclusion (age group: 13–29 years) taken before and 6months after the Forsus treatment were evaluated for apical root resorption, tooth inclination, marginal bone height, and thicknessof bone at the mid-root and apical level in mandibular anterior teeth.Results: There was statistically significant root resorption of central incisors (0.39 mm) and canines (0.66 mm); a decrease in the angleof inclination for all teeth; an increase in the marginal bone measurement in labial (1.31 mm) and decrease in lingual (0.93 mm) aspectat the canine region; and an increase in bone width by 0.87 mm and 0.75 mm in central and lateral incisor regions, respectively, at themid-root level lingually. At the apex level in the canine region, bone width increased by 1.4 mm labially, while it decreased by 2.18 mmlingually; it increased significantly for incisors in the lingual region.Conclusion: The Forsus appliance therapy causes clinically insignificant root resorption and bone changes, and clinically significantproclination of mandibular anterior teeth. The findings of the present study aid clinicians in proper case selection and reinforce theprevention of incisor proclination while using the Forsus therapy to achieve better treatment results and stability.