The practice of quarantine was among the precautions against the Black Sea Region epidemic in the 19th century. The Ottoman Government established an administration for quarantine, which was institutionalized in 1838. It turned into a large organization and expanded to the provinces in a short time, including Batum, a border town in the Eastern Black Sea with Russia. Batum had a special significance for the Ottoman Empire in the 19th century. Batum Quarantine was imposed during the reign of Sultan Abdülmecid, with compelling sanitary controls in the Eastern Black Sea for many years until the Eastern Black Sea border shifted to Hopa when Batum was lost according to Treaty of Berlin. Henceforth, Hopa Quarantine at the Sanjak of Lazistan was further institutionalized. Towards the end of the century, the Hopa Quarantine was temporarily transformed into a tahaffuzhane to lessen the burden of Kavak and Sinop, two major tahaffuzhanes at the time in the Black Sea coast. This paper sheds light on how the Hopa quarantine was made better in the Sultan Hamid II period than the one previously established before the loss of Batumi and why Hopa quarantine was transformed into a tahaffuzhane.