Yıl: 2020 Cilt: 5 Sayı: 1 Sayfa Aralığı: 47 - 50 Metin Dili: İngilizce DOI: DOI: 10.5152/cjms.2020.748 İndeks Tarihi: 21-10-2020

Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis

Öz:
BACKGROUND/AIMSThis study aimed to compare the outcomes of platelet-rich plasma (PRP) and hyaluronic acid (HA) injections in early-stage gonarthrosis.MATERIAL and METHODSRadiographs were examined retrospectively, and 60 patients with Kellgren Lawrence Stage 1, 2, and 3 were included in the study. Twentyeight patients were administered HA, and 32 patients were administered PRP. PRP injections were administered three times in totalwith two-week intervals, while the HA injection was used once. The initial, 1-month, and 6-month follow-up records were obtained. TheWestern Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (pain, stiffness, physical function) and Visual Analog Scale(VAS) scores were evaluated.RESULTSNo statistically significant difference was observed between the HA and PRP groups. When the WOMAC scores were evaluated, it wasseen that the function, joint stiffness, and overall WOMAC scores were positively affected in both the groups; however, there was nodifference between the two groups.CONCLUSIONPRP is a novel treatment option in knee osteoarthritis (OA) management, and an increasing number of clinical studies have shownpromising results. Both PRP and HA have positive effect in patients with early gonarthrosis; however, the results indicated no superiorityin the PRP group.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Wong LY, Yiu RL, Chiu CK, Lee WK, Lee YL, Kwong PK, et al. Prevalence of Psychiatric Morbidity in Chinese Subjects with Knee Osteoarthritis in a Hong Kong Orthopaedic Clinic East Asian Arch Psychiatry 2015; 25(4): 150-8.
  • 2. Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage 2013; 21(9): 1145-53. [CrossRef]
  • 3. Michael JW, Schlüter-Brust KU and Eysel P. The epidemiology, etiology, diagnosis and treatment of osteoarthritis of the knee. Dtsch Arztebl Int 2010; 107(9): 152-62. [CrossRef]
  • 4. Sinusas K. Osteoarthritis: diagnosis and treatment. Am Fam Physician 2012; 85(1): 49-56.
  • 5. Chang KV, Hung CY, Aliwarga F, Wang TG, Han DS, Chen WS, et al. Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. Arch Phys Med Rehabil 2014; 95(3): 562- 75. [CrossRef]
  • 6. Khoshbin A, Leroux T, Wasserstein D, Marks P, Theodoropoulos J, Ogilvie-Harris D, et al. The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy 2013; 29(12): 2037-48. [CrossRef]
  • 7. Dold AP, Zywiel MG, Taylor DW, Dwyer T, Theodoropoulos J. Platelet-rich plasma in the management of articular cartilage pathology: a systematic review. Clin J Sport Med 2014; 24(1): 31-43. [CrossRef]
  • 8. Rodriguez-Merchan EC. Intra-articular Injections of Hyaluronic Acid and Other Drugs in the Knee Joint HSS J 2013; 9(2): 180-2. [CrossRef]
  • 9. Vaquerizo V, Plasencia MÁ, Arribas I, Seijas R, Padilla S, Orive G, et al. Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: a randomized controlled trial. Arthroscopy 2013; 29(10): 1635-43. [CrossRef]
  • 10. Filardo G, Kon E, Di Martino A, Di Matteo B, Merli ML, Cenacchi A, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord 2012; 23; 13:229. [CrossRef]
  • 11. Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, et al. Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial. Am J Sports Med 2015; 43(7): 1575-82. [CrossRef]
  • 12. Sadabad HN, Behzadifar M, Arasteh F, Behzadifar M, Dehghan HR. Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis. Electronic Physician 2016; 8(3): 2115-22. [CrossRef]
  • 13. Cerza F, Carnì S, Carcangiu A, Di Vavo I, Schiavilla V, Pecora A, et al. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med 2012; 40(12): 2822-7. [CrossRef]
APA BEKTAS Y, GURAN O, demirkiran n, OZMANEVRA R (2020). Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. , 47 - 50. DOI: 10.5152/cjms.2020.748
Chicago BEKTAS Yunus Emre,GURAN Ortac,demirkiran nihat demirhan,OZMANEVRA Ramadan Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. (2020): 47 - 50. DOI: 10.5152/cjms.2020.748
MLA BEKTAS Yunus Emre,GURAN Ortac,demirkiran nihat demirhan,OZMANEVRA Ramadan Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. , 2020, ss.47 - 50. DOI: 10.5152/cjms.2020.748
AMA BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. . 2020; 47 - 50. DOI: 10.5152/cjms.2020.748
Vancouver BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. . 2020; 47 - 50. DOI: 10.5152/cjms.2020.748
IEEE BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R "Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis." , ss.47 - 50, 2020. DOI: 10.5152/cjms.2020.748
ISNAD BEKTAS, Yunus Emre vd. "Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis". (2020), 47-50. https://doi.org/DOI: 10.5152/cjms.2020.748
APA BEKTAS Y, GURAN O, demirkiran n, OZMANEVRA R (2020). Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. Cyprus Journal of Medical Sciences, 5(1), 47 - 50. DOI: 10.5152/cjms.2020.748
Chicago BEKTAS Yunus Emre,GURAN Ortac,demirkiran nihat demirhan,OZMANEVRA Ramadan Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. Cyprus Journal of Medical Sciences 5, no.1 (2020): 47 - 50. DOI: 10.5152/cjms.2020.748
MLA BEKTAS Yunus Emre,GURAN Ortac,demirkiran nihat demirhan,OZMANEVRA Ramadan Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. Cyprus Journal of Medical Sciences, vol.5, no.1, 2020, ss.47 - 50. DOI: 10.5152/cjms.2020.748
AMA BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. Cyprus Journal of Medical Sciences. 2020; 5(1): 47 - 50. DOI: 10.5152/cjms.2020.748
Vancouver BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis. Cyprus Journal of Medical Sciences. 2020; 5(1): 47 - 50. DOI: 10.5152/cjms.2020.748
IEEE BEKTAS Y,GURAN O,demirkiran n,OZMANEVRA R "Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis." Cyprus Journal of Medical Sciences, 5, ss.47 - 50, 2020. DOI: 10.5152/cjms.2020.748
ISNAD BEKTAS, Yunus Emre vd. "Comparison of Platelet-Rich Plasma and Hyaluronic Acid for Treatment of Early Stage Gonarthrosis". Cyprus Journal of Medical Sciences 5/1 (2020), 47-50. https://doi.org/DOI: 10.5152/cjms.2020.748