Objectives: This study aims to compare the clinical andradiological outcomes of the two fixation methods frequently usedin the treatment of Schatzker type II fractures: lag screw fixationand lateral anatomic plate fixation.Patients and methods: This retrospective study, which wasconducted between January 2005 and December 2014, included61 patients (41 males, 20 females; mean age 43.4±13.1 years;range, 20 to 76 years) with Schatzker type II (Orthopaedic TraumaAssociation (OTA)/Arbeitsgemeinschaft für Osteosynthesefragen(AO) 41-B3) fractures. Patients were divided into two groupsaccording to the type of surgery as cannulated lag screw fixationgroup (group 1, n=24, 39.4%) and lateral locking plate fixationgroup (group 2, n=37, 60.6%). Intraoperative mediolateral andanteroposterior instability were measured. Final knee flexionextention range of motion (ROM), single-leg hop test, KneeSociety Score (KSS), Hospital for Special Surgery (HSS) and shortform 36 (SF36) scores were obtained at the last follow-up.Results: The mean age of patients was 42.1±13.8 years in group2 and 45.5±12.2 years in group 1. The mean follow-up period was34±4 months. Minimal or no arthritis was detected in 75% (n=18) ofpatients in group 1 and 78% (n=29) of patients in group 2 (p=0.27).Single leg-hop test results (p=0.55), final follow-up knee ROM(p=0.40), KSS (p=0.21), HSS (p=0.15), and SF36 scores of group 1were similar to group 2. In group 1, the duration of surgery wasshorter (p<0.001) and the cost of treatment was lower (p<0.001).Conclusion: Treatment of Schatzker type II tibial plateau fractureswith lag screws seems to provide less invasive, cheaper, and fastersurgical treatment as compared with lateral locking plate fixation.In addition, patients who underwent internal fixation with lagscrews had similar clinical and radiological outcomes with thosewho underwent lateral locking plate fixation.