Yıl: 2020 Cilt: 21 Sayı: 2 Sayfa Aralığı: 218 - 221 Metin Dili: İngilizce DOI: 10.5455/apd.53708 İndeks Tarihi: 15-10-2020

The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases

Öz:
Autism spectrum disorder (ASD) is characterized by deficits in social interactions and communication, and restricted and stereotypic behaviors. A growing body of evidence has identified metabolic pathways and glutamatergic neurotransmission affecting oxidative stress levels as potential targets of drug development in autism spectrum disorders. N-acetylcysteine (NAC) is an antioxidant that modulate glutamate and reduce oxidative stress, both associated with the pathophysiology of ASD. N-acetylcysteine has been identified as a potential treatment agent for irritability and self-injurious behaviors in autism. In this case report, we report six cases of autism with severe symptoms of irritability and aggression, two of them responded well to N-acetylcysteine treatment, two of them responded partially and while two did not. (Anatolian Journal of Psychiatry 2020; 21(2):218-221)
Anahtar Kelime:

Şiddetli irritabilite ve saldırganlığı olan otistik çocuklarda Nasetilsistein augmentasyonunun etkinliği ve güvenilirliği: Altı olgu

Öz:
Otizm spektrum bozukluğu (OSB) sosyal-iletişimsel alanda belirgin yetersizlikler ve sınırlı, yineleyici davranışlar ve ilgi alanları ile karakterizedir. Gittikçe artan sayıda kanıt, glutamaterjik nörotransmisyonu ve oksidatif stres düzeylerini etkileyen metabolik yolları otizm spektrum bozukluklarında ilaç gelişiminin potansiyel hedefleri olarak tanımlamıştır. N-asetilsistein (NAC), ikisi de OSB'nin patofizyolojisi ile ilişkili olarak glutamatı modüle eden ve oksidatif stresi azaltan bir antioksidandır. N-asetilsistein, otizmde irritabilite ve kendine zarar verme davranışları için potansiyel bir tedavi ajanı olarak tanımlanmıştır. Bu olgu sunumunda ağır saldırganlık ve irritabilite belirtileri olan altı otizmli hastada N-asetilsistein tedavisi sunulmuştur. Altı olgunun ikisi tedaviye iyi yanıt verirken, diğer ikisinde kısmi yanıt saptanmıştır. İki olgu ise tedaviye yanıt vermemiştir. (Anadolu Psikiyatri Derg 2020; 21(2):218-221)
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA ÖNDER A, ADANIR SÜRER A, GİZLİ ÇOBAN Ö, Bilaç Ö, KARA A (2020). The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. , 218 - 221. 10.5455/apd.53708
Chicago ÖNDER Arif,ADANIR SÜRER Aslı,GİZLİ ÇOBAN ÖZGE,Bilaç Öznur,KARA Aziz The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. (2020): 218 - 221. 10.5455/apd.53708
MLA ÖNDER Arif,ADANIR SÜRER Aslı,GİZLİ ÇOBAN ÖZGE,Bilaç Öznur,KARA Aziz The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. , 2020, ss.218 - 221. 10.5455/apd.53708
AMA ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. . 2020; 218 - 221. 10.5455/apd.53708
Vancouver ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. . 2020; 218 - 221. 10.5455/apd.53708
IEEE ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A "The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases." , ss.218 - 221, 2020. 10.5455/apd.53708
ISNAD ÖNDER, Arif vd. "The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases". (2020), 218-221. https://doi.org/10.5455/apd.53708
APA ÖNDER A, ADANIR SÜRER A, GİZLİ ÇOBAN Ö, Bilaç Ö, KARA A (2020). The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. Anadolu Psikiyatri Dergisi, 21(2), 218 - 221. 10.5455/apd.53708
Chicago ÖNDER Arif,ADANIR SÜRER Aslı,GİZLİ ÇOBAN ÖZGE,Bilaç Öznur,KARA Aziz The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. Anadolu Psikiyatri Dergisi 21, no.2 (2020): 218 - 221. 10.5455/apd.53708
MLA ÖNDER Arif,ADANIR SÜRER Aslı,GİZLİ ÇOBAN ÖZGE,Bilaç Öznur,KARA Aziz The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. Anadolu Psikiyatri Dergisi, vol.21, no.2, 2020, ss.218 - 221. 10.5455/apd.53708
AMA ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. Anadolu Psikiyatri Dergisi. 2020; 21(2): 218 - 221. 10.5455/apd.53708
Vancouver ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases. Anadolu Psikiyatri Dergisi. 2020; 21(2): 218 - 221. 10.5455/apd.53708
IEEE ÖNDER A,ADANIR SÜRER A,GİZLİ ÇOBAN Ö,Bilaç Ö,KARA A "The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases." Anadolu Psikiyatri Dergisi, 21, ss.218 - 221, 2020. 10.5455/apd.53708
ISNAD ÖNDER, Arif vd. "The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases". Anadolu Psikiyatri Dergisi 21/2 (2020), 218-221. https://doi.org/10.5455/apd.53708