Yıl: 2020 Cilt: 6 Sayı: 1 Sayfa Aralığı: 112 - 118 Metin Dili: Türkçe DOI: 10.17954/amj.2019.2298 İndeks Tarihi: 14-10-2020

Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı

Öz:
Amaç: Akromegali hastalarında kolon polipi prevelansı artmıştır. Kolon poliplerinin malignpotansiyele sahip olabilmeleri ve saptanan poliplerin eksizyonunun kolon kanseri insidansını azaltmasınedeni ile akromegali hastalarında kolonoskopi taramalarının hasta izleminin bir parçası olmasıönerilmektedir. Çalışmada akromegali hastalarında kolon patolojilerini ve kolon polipi sıklığını veilişkili oldukları faktörleri araştırmayı amaçladık.Gereç ve Yöntemler: Total kolonoskopileri yapılmış 70 akromegali hastasının kayıtları retrospektifolarak incelendi. Kolonoskopi raporları incelenerek saptanan divertikül ve polip gibi patolojikbulgular, poliplerin yerleşim yerleri ve patoloji sonuçları incelendi. Kolon polipi olan ve olmayanhastaların verileri karşılaştırıldı.Bulgular: Hastaların medyan yaşları 49 (38-70) yıldı ve 42’si (%60) kadındı. Hastaların %62,8’inde(n=44) kolonoskopi sonuçları normal olarak raporlanmıştı. Hastaların %21,4’ünde (n=15) toplam20 adet polip, %10’unda (n=7) divertikül saptandı. Polipler en sık transvers kolonda (%35, n=7)) veikinci sıklıkta rektumda (%25, n=5) lokalizeydi. Saptanan poliplerin %50’si (n=10) hiperplastik polip,%45’i (n=9) adenomatöz polip ve %5’i (n=1) lipom idi. İki kez kolonoskopi yapılan hastaların (n=32)%18,5’inde (n=6) ikinci kolonoskopilerinde polip saptanmıştır.Sonuç: Çalışmamız akromegali hastalarında yeni kolon polipi saptama ihtimalinin az olmadığını veilk kolonoskopi sonrası aktif kolonoskopi takiplerinin devamının uygun olduğunu göstermiştir.
Anahtar Kelime:

Colonoscopy Findings and Colon Polyp Frequency in Patients with Acromegaly

Öz:
Objective: The prevalence of colon polyps is increased in acromegaly patients. Colon polyps may have malignant potential and excision reduces the colon cancer incidence. Screening with colonoscopy should therefore be included in the follow-up in acromegaly. In this study, we investigated colon pathologies, the frequency of colon polyps and related factors in acromegaly patients. Material and Methods: The retrospective records of 70 acromegaly patients who underwent colonoscopy were reviewed. Colonoscopy reports were examined and findings such as diverticulosis and polyps, polyp location and pathology results were evaluated. The data of the patients with and without colon polyps were compared. Results: The median age of the patients was 49 (38-70) years and 42 (60%) were female. Colonoscopy results were normal in 62.8% (n=44). A total of 20 polyps were detected in 21.4% (n=15) and diverticulosis was found in 10% (n=7). Polyps were most commonly localized in the transverse colon (35%, n = 7) and secondly in the rectum (25%, n=5). Of these polyps, 50% (n=10) were hyperplastic, 45% (n=9) were adenomatous and 5% (n=1) were lipomas. Polyps were detected during the second colonoscopy (n=32) in 18.5% (n=6) of the patients. Conclusion: Our study showed that the probability of detecting new colon polyps in acromegaly patients is not low and that repeated colonoscopic follow-up is appropriate
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Melmed S. Medical progress: Acromegaly. N Engl J Med 2006; 355:2558-73.
  • 2. Rokkas T, Pistiolas D, Sechopoulos P, Margantinis G, Koukoulis G. Risk of colorectal neoplasm in patients with acromegaly: A meta-analysis. World J Gastroenterol 2008; 14:3484-89.
  • 3. Baldys-Waligorska A, Krzentowska A, Golkowski F, Sokolowski G, Hubalewska-Dydejczyk A. The prevalence of benign and malignant neoplasms in acromegalic patients. Endokrynol Pol 2010; 61:29-34.
  • 4. Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992; 326:658-62.
  • 5. Katznelson L, Laws ER, Jr., Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine S. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014; 99:3933-51.
  • 6. Mechanick JI, Bergman DA, Braithwaite SS, Palumbo PJ, American Association of Clinical Endocrinologists Ad Hoc Task Force for Standardized Production of Clinical Practice G. American Association of Clinical Endocrinologists protocol for standardized production of clinical practice guidelines. Endocr Pract 2004; 10:353-61.
  • 7. Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K, Melmed S, Acromegaly Consensus G. A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metab 2010; 95:3141-8.
  • 8. Delhougne B, Deneux C, Abs R, Chanson P, Fierens H, Laurent-Puig P, Duysburgh I, Stevenaert A, Tabarin A, Delwaide J, Schaison G, Belaiche J, Beckers A. The prevalence of colonic polyps in acromegaly: A colonoscopic and pathological study in 103 patients. J Clin Endocrinol Metab 1995; 80:3223-6.
  • 9. Koksal AR, Ergun M, Boga S, Alkim H, Bayram M, Altuntas Y, Ozguven Yilmaz B, Alkim C. Increased prevalence of colorectal polyp in acromegaly patients: A case-control study. Diagn Ther Endosc 2014; 2014:152049.
  • 10. Petrossians P, Daly AF, Natchev E, Maione L, Blijdorp K, Sahnoun-Fathallah M, Auriemma R, Diallo AM, Hulting AL, Ferone D, Hana V, Jr., Filipponi S, Sievers C, Nogueira C, Fajardo-Montanana C, Carvalho D, Hana V, Stalla GK, Jaffrain-Rea ML, Delemer B, Colao A, Brue T, Neggers S, Zacharieva S, Chanson P, Beckers A. Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database. Endocr Relat Cancer 2017; 24:505-18.
  • 11. Gonzalez B, Vargas G, Mendoza V, Nava M, Rojas M, Mercado M. The prevalence of colonic polyps in patients with acromegaly: A case-control, nested in a cohort colonoscopic study. Endocr Pract 2017; 23:594-9.
  • 12. Iliaz R, Dogansen SC, Tanrikulu S, Yalin GY, Cavus B, Gulluoglu M, Akyuz F, Yarman S. Predictors of colonic pathologies in active acromegaly: Single tertiary center experience. Wien Klin Wochenschr 2018; 130:511-6.
  • 13. Bogazzi F, Cosci C, Sardella C, Costa A, Manetti L, Gasperi M, Rossi G, Bartalena L, Martino E. Identification of acromegalic patients at risk of developing colonic adenomas. J Clin Endocrinol Metab 2006; 91:1351-6.
  • 14. Berker D, Ates Tutuncu Y, Isik S, Aydin Y, Ozuguz Y, Akbaba G, Yuksel O, Erden G, Altiparmak E, Guler S. Prevalence and recurrence rate of colonic lesions in acromegalic patients. Cent Eur J Med 2010; 5:704-11.
  • 15. Kurtulmus N, Yarman, S., Demir, K. Association between skin tags and colonic polyps in patients with acromegaly. Turkish Journal of Endocrinology and Metabolism 2005; 9:45-47.
  • 16. Eminler AT, Sakalli M, Irak K, Ayyildiz T, Keskin M, Yogurt I, Gulten M, Kiyici M, Gurel S, Dolar E, Nak SG. Colonoscopic polypectomy results of our gastroenterology unit. The Journal of Academic Gastroenterology 2011; 10:112-5.
  • 17. Colao A, Pivonello R, Auriemma RS, Galdiero M, Ferone D, Minuto F, Marzullo P, Lombardi G. The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. J Clin Endocrinol Metab 2007; 92:3854-60.
  • 18. Terzolo M, Reimondo G, Gasperi M, Cozzi R, Pivonello R, Vitale G, Scillitani A, Attanasio R, Cecconi E, Daffara F, Gaia E, Martino E, Lombardi G, Angeli A, Colao A. Colonoscopic screening and follow-up in patients with acromegaly: A multicenter study in Italy. J Clin Endocrinol Metab 2005; 90:84-90.
  • 19. Iwamuro M, Yasuda M, Hasegawa K, Fujisawa S, Ogura-Ochi K, Sugihara Y, Harada K, Hiraoka S, Okada H, Otsuka F. Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals. Endocr J 2018; 65:151-7.
  • 20. Renehan AG, Bhaskar P, Painter JE, O’Dwyer ST, Haboubi N, Varma J, Ball SG, Shalet SM. The prevalence and characteristics of colorectal neoplasia in acromegaly. J Clin Endocrinol Metab 2000; 85:3417-24.
  • 21. Martino A, Cammarota G, Cianci R, Bianchi A, Sacco E, Tilaro L, Marzetti E, Certo M, Pirozzi G, Fedeli P, Pandolfi F, Pontecorvi A, Gasbarrini G, De Marinis L. High prevalence of hyperplastic colonic polyps in acromegalic subjects. Dig Dis Sci 2004; 49:662-6.
  • 22. Wassenaar MJ, Cazemier M, Biermasz NR, Pereira AM, Roelfsema F, Smit JW, Hommes DW, Felt-Bersma RJ, Romijn JA. Acromegaly is associated with an increased prevalence of colonic diverticula: A case-control study. J Clin Endocrinol Metab 2010; 95:2073-9.
  • 23. Petroff D, Tonjes A, Grussendorf M, Droste M, Dimopoulou C, Stalla G, Jaursch-Hancke C, Mai M, Schopohl J, Schofl C. The incidence of cancer among acromegaly patients: Results from the german acromegaly registry. J Clin Endocrinol Metab 2015; 100:3894-902.
  • 24. Dworakowska D, Gueorguiev M, Kelly P, Monson JP, Besser GM, Chew SL, Akker SA, Drake WM, Fairclough PD, Grossman AB, Jenkins PJ. Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines. Eur J Endocrinol 2010; 163:21-8.
APA YILMAZ N, Tazegul G, SARI R, altunbas h, BALCI M (2020). Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. , 112 - 118. 10.17954/amj.2019.2298
Chicago YILMAZ NUSRET,Tazegul Gokhan,SARI RAMAZAN,altunbas hasan,BALCI Mustafa Kemal Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. (2020): 112 - 118. 10.17954/amj.2019.2298
MLA YILMAZ NUSRET,Tazegul Gokhan,SARI RAMAZAN,altunbas hasan,BALCI Mustafa Kemal Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. , 2020, ss.112 - 118. 10.17954/amj.2019.2298
AMA YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. . 2020; 112 - 118. 10.17954/amj.2019.2298
Vancouver YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. . 2020; 112 - 118. 10.17954/amj.2019.2298
IEEE YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M "Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı." , ss.112 - 118, 2020. 10.17954/amj.2019.2298
ISNAD YILMAZ, NUSRET vd. "Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı". (2020), 112-118. https://doi.org/10.17954/amj.2019.2298
APA YILMAZ N, Tazegul G, SARI R, altunbas h, BALCI M (2020). Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. Akdeniz Tıp Dergisi, 6(1), 112 - 118. 10.17954/amj.2019.2298
Chicago YILMAZ NUSRET,Tazegul Gokhan,SARI RAMAZAN,altunbas hasan,BALCI Mustafa Kemal Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. Akdeniz Tıp Dergisi 6, no.1 (2020): 112 - 118. 10.17954/amj.2019.2298
MLA YILMAZ NUSRET,Tazegul Gokhan,SARI RAMAZAN,altunbas hasan,BALCI Mustafa Kemal Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. Akdeniz Tıp Dergisi, vol.6, no.1, 2020, ss.112 - 118. 10.17954/amj.2019.2298
AMA YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. Akdeniz Tıp Dergisi. 2020; 6(1): 112 - 118. 10.17954/amj.2019.2298
Vancouver YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı. Akdeniz Tıp Dergisi. 2020; 6(1): 112 - 118. 10.17954/amj.2019.2298
IEEE YILMAZ N,Tazegul G,SARI R,altunbas h,BALCI M "Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı." Akdeniz Tıp Dergisi, 6, ss.112 - 118, 2020. 10.17954/amj.2019.2298
ISNAD YILMAZ, NUSRET vd. "Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı". Akdeniz Tıp Dergisi 6/1 (2020), 112-118. https://doi.org/10.17954/amj.2019.2298