Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?
Yıl: 2019 Cilt: 18 Sayı: 1 Sayfa Aralığı: 6 - 9 Metin Dili: İngilizce DOI: 10.4274/uob.galenos.2018.1099 İndeks Tarihi: 29-07-2022
Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?
Öz: Objective: To determine the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) in predicting laminapropria invasion in bladder cancer.Materials and Methods: Eighty-eight patients with non-muscle-invasive bladder cancer were evaluated retrospectively. The patients were dividedinto those with Ta tumors (group 1: n=36) and those with T1 tumors (group 2: n=52). For each patient, white blood cell, neutrophil, and leukocytecounts and RDW values were evaluated.Results: NLR was significantly lower in patients with Ta tumors. In addition, NLR below 3.22 was associated with 80.6% probability of Ta disease.RDW sensitivity in Ta non-muscle-invasive bladder tumors was much higher compared to T1 tumors. RDW below 15.35 was associated with 94.4%probability of Ta disease.Conclusion: NLR and RDW are basic blood parameters that physicians can assess easily. Our results indicate that a combination of NLR and RDW canhelp clinicians predict lamina propria invasion in non-muscle-invasive bladder tumors.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Tiu A, Jenkins LC, Soloway MS. Active surveillance for low-risk bladder cancer. Urol Oncol 2014;32:33.
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30.
- Burger M, Catto JW, Dalbagni G, et al. Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 2013;63:234-241.
- Isharwal S, Konety B. Non-muscle invasive bladder cancer risk stratification. Indian J Urol 2015;31:289-296.
- Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflamation. Nature 2008;454:436-444.
- McMillan DC, Canna K, McArdle CS. Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 2003;90:215-219.
- Kum RO, Ozcan M, Baklaci D, et al. Elevated neutrophil-tolymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev 2014;15:7351-7355.
- Duzlu M, Karamert R, Tutar H, et al. Neutrophil-lymphocyte ratio findings and larynx carcinoma: a preliminary study in Turkey. Asian Pac J Cancer Prev 2015;16:351-354.
- Mano R, Baniel J, Shoshany O, et al. Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non-muscle-invasive bladder cancer. Urol Oncol 2015;33:67.
- Ceylan C, Doluoglu OG, Keleş I, et al. Importance of the neutrophilto- lymphocyte ratio in muscle-invasive and non-muscle invasive bladder tumors. Urologia 2014;81:120-124.
- Krane LS, Richards KA, Kader AK, et al. Preoperative neutrophil/ lymphocyte ratio predicts overall survival and extravesical disease in patients undergoing radical cystectomy. J Endourol 2013;27:1046-1050.
- Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other redblood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS One 2014;9:e111440.
- Yilmaz A, Malya F, Ozturk G, et al. Effect of pre-operative red blood cell distribution on cancer stage and morbidity rate in patients with pancreatic cancer. Int J Clin Exp Med 2014;7:3072-3075.
- Busato Júnior WF, Almeida GL, Ribas CA, et al. EORTC Risk Model to Predict Progression in Patients With Non-Muscle-Invasive Bladder Cancer: Is It Safe to Use in Clinical Practice? Clin Genitourin Cancer 2016;14:176-182.
- Cimen HI, Halis F, Saglam HS, Gokce A. Can neutrophil to lymphocyte ratio predict lamina propria invasion in patients with non muscle invasive bladder cancer? Int Braz J Urol 2017;43:67-72.
- Cheng YC, Huang CN, Wu WJ, et al. The Prognostic Significance of Inflammation Associated Blood Cell Markers in Patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol 2016;23:343-351.
- Paramanathan A, Saxena A, Morris DL. A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol 2014;23:31-39.
- Maltoni M, Caraceni A, Brunelli Cet al. Prognostic factors in advanced cancer patients: evidence-based clinical recommendations--a study by the Steering Committee of the European Association for Palliative Care. J Clin Oncol 2005;23:6240-6248.
- Ozyalvacli ME, Ozyalvacli G, Kocaaslan R, et al. Neutrophillymphocyte ratio as a predictor of recurrence and progression in patients with high-grade pT1 bladder cancer. Can Urol Assoc J 2015;9:126-131.
- Ay S, Eryilmaz MA, Aksoy N, et al. Is early detection of colon cancer possible with red blood cell distribution width? Asian Pac J Cancer Prev 2015;16:753-756.
- Rhodes CJ, Howard LS, Busbridge M, et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights. J Am Coll Cardiol 2011;58:300-309.
- de Gonzalo-Calvo D, de Luxán-Delgado B, Rodríguez-González S, et al. Interleukin 6, soluble tumor necrosis factor receptor I and red blood cell distribution width as biological markers of functional dependence in an elderly population: a translational approach. Cytokine 2012;58:193-198.
- Tetè S, Nicoletti M, Saggini A, et al. Nutrition and cancer prevention. Int J Immunopathol Pharmacol 2012;25:573-581.
- Podhorecka M, Halicka D, Szymczyk A, et al. Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia. Oncotarget 2016;7:32846-32853.
| APA | senturk a, Ekici M, aydin c, baykam m, Tas T, Arda E, Cakiroglu B (2019). Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. , 6 - 9. 10.4274/uob.galenos.2018.1099 |
| Chicago | senturk aykut bugra,Ekici Musa,aydin cemil,baykam mehmet murat,Tas Tuncay,Arda Ersan,Cakiroglu Basri Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. (2019): 6 - 9. 10.4274/uob.galenos.2018.1099 |
| MLA | senturk aykut bugra,Ekici Musa,aydin cemil,baykam mehmet murat,Tas Tuncay,Arda Ersan,Cakiroglu Basri Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. , 2019, ss.6 - 9. 10.4274/uob.galenos.2018.1099 |
| AMA | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. . 2019; 6 - 9. 10.4274/uob.galenos.2018.1099 |
| Vancouver | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. . 2019; 6 - 9. 10.4274/uob.galenos.2018.1099 |
| IEEE | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B "Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?." , ss.6 - 9, 2019. 10.4274/uob.galenos.2018.1099 |
| ISNAD | senturk, aykut bugra vd. "Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?". (2019), 6-9. https://doi.org/10.4274/uob.galenos.2018.1099 |
| APA | senturk a, Ekici M, aydin c, baykam m, Tas T, Arda E, Cakiroglu B (2019). Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni, 18(1), 6 - 9. 10.4274/uob.galenos.2018.1099 |
| Chicago | senturk aykut bugra,Ekici Musa,aydin cemil,baykam mehmet murat,Tas Tuncay,Arda Ersan,Cakiroglu Basri Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni 18, no.1 (2019): 6 - 9. 10.4274/uob.galenos.2018.1099 |
| MLA | senturk aykut bugra,Ekici Musa,aydin cemil,baykam mehmet murat,Tas Tuncay,Arda Ersan,Cakiroglu Basri Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni, vol.18, no.1, 2019, ss.6 - 9. 10.4274/uob.galenos.2018.1099 |
| AMA | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni. 2019; 18(1): 6 - 9. 10.4274/uob.galenos.2018.1099 |
| Vancouver | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni. 2019; 18(1): 6 - 9. 10.4274/uob.galenos.2018.1099 |
| IEEE | senturk a,Ekici M,aydin c,baykam m,Tas T,Arda E,Cakiroglu B "Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?." Üroonkoloji Bülteni, 18, ss.6 - 9, 2019. 10.4274/uob.galenos.2018.1099 |
| ISNAD | senturk, aykut bugra vd. "Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?". Üroonkoloji Bülteni 18/1 (2019), 6-9. https://doi.org/10.4274/uob.galenos.2018.1099 |
