Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects

Talip KARACOR, (Adıyaman Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adıyaman, Türkiye)
Pınar KIRICI, (Adıyaman Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adıyaman, Türkiye)
Mehmet Can NACAR, (Adıyaman Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adıyaman, Türkiye)
Mehmet BÜLBÜL, (Adıyaman Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adıyaman, Türkiye)
Muhittin ÖNDERCİ, (Adıyaman Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Adıyaman, Türkiye)
Nurullah PEKER (Dicle Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Diyarbakır, Türkiye)
Annals of Medical Research
4 1
Yıl: 2020 Cilt: 27 Sayı: 2 Sayfa Aralığı: 454 - 460 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.12.889 İndeks Tarihi: 15-10-2020

Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects

Öz:
Aim: The etiology of neural tube defect (NTD) is still not clear enough. In our study, we aimed to evaluate plasma heavy metal levelsof pregnant women with NTD and to determine whether there is a relationship between heavy metal levels and NTD severity.Material and Methods: TThis study was conducted in Adıyaman University, Department of Gynaecology and Obstetrics. The studyincluded 38 pregnant women with NTD and 42 pregnant women with healthy infants. Pregnant women who have NTD were dividedinto two groups as NTD Type 1 and NTD Type 2 according to the anomaly type. Levels of heavy metals such as Mercury (Hg),Cadmium (Cd), Cobalt (Co), Lead (Pb), Manganese (Mn) and Arsenic (As) were compared between groups.Results: Plasma Hg, Co, Cd and Pb levels were higher in NTD group than control group. (p values, respectively; p <0.001, p = 0.001, p<0.001, p <0.001). As and Mn levels were not statistically different between the two groups (p values; p = .519, p = .819, respectively).In the NTD group, Hg was found to be higher in NTD Type 1 than NTD Type 2 (p <0.001).Conclusion: It is obvious that some histomorphological changes are formed in the cardinal ligaments of patients with uterineprolapse due to pressure on the uterus. We believe that the increase in the number of extravasated erythrocytes and the thicknessof the vascular wall and peripheral nerve should be supported by further studies.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Wang ZP, Shang XX, Zhao ZT. Low maternal vitamin B(12) is a risk factor for neural tube defects: a metaanalysis. J Matern Fetal Neonatal Med 2012;25:389-94.
  • 2. Gu X, Lin LM, Zheng XY, et al. High prevalence of NTDs in Shanxi Province: a combined epidemiological approach. Birth Defects Res A Clin Mol Teratol 2007;79:702-7.
  • 3. Cherian A, Seena S, Bullock RK, et al. Incidence of neural tube defects in the least-developed area of India: a population-based study. The Lancet 2005;366:930-1.
  • 4. Padmanabhan R. Etiology, pathogenesis and prevention of neural tube defects. Congenit Anom 2006;46:55-67.
  • 5. Rajab A, Vaishnav A, Freeman NV, et al. Neural tube defects and congenital hydrocephalus in the Sultanate of Oman. J Tropical Pediatrics 1998;44:300-3.
  • 6. Zaganjor I, Sekkarie A, Tsang BL, et al. Describing the prevalence of neural tube defects worldwide: a systematic literature review. PloS one 2016;11:0151586.
  • 7. Heseker HB, Mason JB, Selhub J, et al. Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr 2009;102:173-80.
  • 8. Bell KN, Oakley GP. Tracking the prevention of folic acid–preventable spina bifida and anencephaly. Birth Defect Res A 2006;76:654-7.
  • 9. Demir N, Başaranoğlu M, Huyut Z, et al. The relationship between mother and infant plasma trace element and heavy metal levels and the risk of neural tube defect in infants. J Matern Fetal Neonatal Med 2019;32:1433- 40.
  • 10. Liu J, Jin L, Zhang L, et al. Placental concentrations of manganese and the risk of fetal neural tube defects. Journal of Trace Elements in Medicine and Biology 2013;27:322-5.
  • 11. Detrait ER, George TM, Etchevers HC, et al. Human neural tube defects: developmental biology, epidemiology, and genetics. Neurotoxicology and teratology 2005;27:515-24.
  • 12. Wertelecki W, Yevtushok L, Kuznietsov I, et al. Chornobyl, radiation, neural tube defects, and microcephaly. European journal of medical genetics. 2018;61:556-63.
  • 13. Brender JD, Suarez L, Felkner M, et al. Maternal exposure to arsenic, cadmium, lead, and mercury and neural tube defects in offspring. Environ Res 2006;101:132-9.
  • 14. Wang B, Zhu Y, Yan L, et al. Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China. Environment international. 2019;126:222-7.
  • 15. Özdabak HN, Karaoğlanoğlu S, Akgül N, et al. The effects of amalgam restorations on plasma mercury levels and total antioxidant activity. Archives of oral biology 2008;53:1101-6.
  • 16. Hamlin HJ, Guillette LJ. Embryos as targets of endocrine disrupting contaminants in wildlife. Birth Defects Res C Embryo Today 2011;93:19-33.
  • 17. Özel Ş, Ozyer S, Aykut O, et al. Maternal second trimester blood levels of selected heavy metals in pregnancies complicated with neural tube defects. J Matern Fetal Neonatal Med 2019;32:2547-53.
  • 18. Spyker JM, Smithberg M. Effects of methylmercury on prenatal development in mice. Teratology 1972;5:181- 90.
  • 19. Hassan SA, Moussa EA, Abbott LC. The effect of methylmercury exposure on early central nervous system development in the zebrafish (Danio rerio) embryo. Journal of Applied Toxicology 2012;32:707- 13.
  • 20. Jin L, Liu M, Zhang L et al. Exposure of methyl mercury in utero and the risk of neural tube defects in a Chinese population. Reproductive Toxicology 2016;61:131-5.
  • 21. Zhang GB, Wang H, Hu J et al. Cadmium-induced neural tube defects and fetal growth restriction: Association with disturbance of placental folate transport. Toxicology and Applied Pharmacology 2016;306:79-85.
  • 22. Webster WS, Messerle K. Changes in the mouse neuroepithelium associated with cadmium-induced neural tube defects. Teratology 1980;21:79-88.
  • 23. Jiang H, Liu F, Yang H et al. Effects of cobalt nanoparticles on human T cells in vitro. Biological Trace Element Research 2012;146:23-9.
  • 24. Olivieri G, Hess C, Savaskan E et al. Melatonin protects SHSY5Y neuroblastoma cells from cobaltinduced oxidative stress, neurotoxicity and increased β-amyloid secretion. Journal of pineal research. 2001;31:320-5.
  • 25. Oldenburg M, Wegner R, Baur X. Severe cobalt intoxication due to prosthesis wear in repeated total hip arthroplasty. The J Arthroplasty 2009;24:825-15.
  • 26. Jiang H, Liu F, Yang H et al. Effects of cobalt nanoparticles on human T cells in vitro. Biol Trace Elem Res 2012;146:23-9.
  • 27. Jordan CM, Whitman RD, Harbut M. Memory deficits and industrial toxicant exposure: a comparative study of hard metal, solvent and asbestos workers. Int. J. Neurosci 1997;90:113-28.
  • 28. Karovic O, Tonazzini I, Rebola N, et al. Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha. Biochem. Pharmacol 2007;73:694-708.
  • 29. Yang SJ, Pyen J, Lee I, et al. Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells. J Biochem Mol Biol 2004;37:480-6.
  • 30. Oberdörster G. Oberdörster. E. Oberdörster. J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005;113:823-39.
  • 31. Zheng F, Luo Z, Zheng C et al. Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats. Toxicol Appl Pharmacol 2019;369:90-9.
  • 32. Tang N, Zhu ZQ. Adverse reproductive effects in female workers of lead battery plants. International J Occupational Med and Environmental Health 2003;16:359-61.
  • 33. Dawson EB, Evans DR, Harris WA, et al. Amniotic fluid B12, calcium, and lead levels associated with neural tube defects. American J Perinatology 1999;16:373-8.
  • 34. Mousa AM, Al-Fadhli AS, Rao MS, et al. Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats. Drug and chemical toxicology 2015;38:73-83.
  • 35. Vinceti M, Rovesti S, Bergomi M, et al. Risk of birth defects in a population exposed to environmental lead pollution. Science of the Total Environment 2001;278:23-30.
  • 36. Jin L, Zhang L, Li Z, et al. Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population. Reproductive toxicology 2013;35:25-31.
  • 37. Bound JP, Harvey PW, Francis BJ, et al. Involvement of deprivation and environmental lead in neural tube defects: a matched case-control study. Archives Of Disease In Childhood 1997;76:107-12.
APA karaçor t, Kırıcı P, NACAR M, BULBUL M, Önderci M, Peker N (2020). Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. , 454 - 460. 10.5455/annalsmedres.2019.12.889
Chicago karaçor talip,Kırıcı Pınar,NACAR MEHMET CAN,BULBUL Mehmet,Önderci Muhittin,Peker Nurullah Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. (2020): 454 - 460. 10.5455/annalsmedres.2019.12.889
MLA karaçor talip,Kırıcı Pınar,NACAR MEHMET CAN,BULBUL Mehmet,Önderci Muhittin,Peker Nurullah Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. , 2020, ss.454 - 460. 10.5455/annalsmedres.2019.12.889
AMA karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. . 2020; 454 - 460. 10.5455/annalsmedres.2019.12.889
Vancouver karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. . 2020; 454 - 460. 10.5455/annalsmedres.2019.12.889
IEEE karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N "Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects." , ss.454 - 460, 2020. 10.5455/annalsmedres.2019.12.889
ISNAD karaçor, talip vd. "Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects". (2020), 454-460. https://doi.org/10.5455/annalsmedres.2019.12.889
APA karaçor t, Kırıcı P, NACAR M, BULBUL M, Önderci M, Peker N (2020). Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. Annals of Medical Research, 27(2), 454 - 460. 10.5455/annalsmedres.2019.12.889
Chicago karaçor talip,Kırıcı Pınar,NACAR MEHMET CAN,BULBUL Mehmet,Önderci Muhittin,Peker Nurullah Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. Annals of Medical Research 27, no.2 (2020): 454 - 460. 10.5455/annalsmedres.2019.12.889
MLA karaçor talip,Kırıcı Pınar,NACAR MEHMET CAN,BULBUL Mehmet,Önderci Muhittin,Peker Nurullah Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. Annals of Medical Research, vol.27, no.2, 2020, ss.454 - 460. 10.5455/annalsmedres.2019.12.889
AMA karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. Annals of Medical Research. 2020; 27(2): 454 - 460. 10.5455/annalsmedres.2019.12.889
Vancouver karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects. Annals of Medical Research. 2020; 27(2): 454 - 460. 10.5455/annalsmedres.2019.12.889
IEEE karaçor t,Kırıcı P,NACAR M,BULBUL M,Önderci M,Peker N "Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects." Annals of Medical Research, 27, ss.454 - 460, 2020. 10.5455/annalsmedres.2019.12.889
ISNAD karaçor, talip vd. "Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects". Annals of Medical Research 27/2 (2020), 454-460. https://doi.org/10.5455/annalsmedres.2019.12.889
Sayfa Oluşturulma Tarihi
17-04-2024 16:10

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