The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study
Yıl: 2019 Cilt: 20 Sayı: 1 Sayfa Aralığı: 82 - 86 Metin Dili: İngilizce DOI: 10.4274/meandros.galenos.2018.72692 İndeks Tarihi: 18-10-2020
The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study
Öz: Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats’ bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats’ bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to group 1, and ibuprofen to group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in group 2, and the relaxation response reached the baseline tonus in this group.Conclusion: Intraoperative analgesia is very important in preventing post-operative complications and ensuring patient comfort. In general, opioids and concomitant nonsteroidal anti-inflammatory or paracetamol group drugs are preferred intraoperatively for post-operative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm.
Anahtar Kelime: Parasetamol ve Ibuprofenin Bronkospazm Oluşturulmuş Bronş Düz Kas Dokusunda Etkileri: In Vitro Çalışma
Öz: Amaç: Bronkospazm post-operastif ve intraoperatif dönem boyunca karşılaşılabilen çok önemli bir komplikasyondur. Bu komplikasyon cerrahi, anestezi ve hastaya ait nedenlerle oluşabilmektedir. Post-operatif analjezi oluşturmak için intraoperatif dönemde rutinde pek çok analjezik tercih edilmektedir. Bizde bu çalışmada in vitro şartlarda bir bronkospazm modeli olarak supramaksimal tonuslü rat trakeasında intravenöz analjeziklerden ibuprofen ve parasetamolün etkilerini görmeyi amaçladık.Gereç ve Yöntemler: Çalışmamızda toplam 20 erkek rat kullanıldı. Ketamin anestezisi sonrası her ratın sol ana bronşları çıkarılarak Krebs solüsyonunda organ banyosuna asıldı. Dört rat bronşu asetilkolin ve atropine cevap alınamadığı için çalışma dışı bırakıldı. Canlılığı kanıtlanan rat bronşlarına (n=16) asetilkolin uygulanarak supramaksimal kontraksiyon oluşturuldu. Supramaksimal kontraksiyon oluşturulan rat bronşları randomize olarak iki gruba ayrıldı. grup 1’e (n=8) parasetamol, grup 2’e (n=8) ibuprofen uygulandı. Her bir grubun kontraksiyon cevapları kaydedildi ve sonra istatistiksel olarak karşılaştırıldı.Bulgular: Supramaksimal kontraksiyonda grup 1’de ortalama %0,18±0,07 ile istatistiksel olarak anlamlı bir değişiklik saptanmazken (p>0,05) grup 2’de ortalama %6,79±0,28 (p<0.05) tonusu düşüşü izlenerek bazal değerlere indiği belirlendi. Sonuç: İntraoperatif analjezi post-operatif komplikasyonların önlenmesinde ve hasta konforunun sağlanmasında çok önemlidir. Genel olarak post-operatif analjezi için intraoperatif olarak opioidler ve beraberinde non-steroid anti-enflamatuvar ilaçlar veya parasetamol grubu ilaçlar tercih edilmektedir. Çalışmamızda tonusu artırılmış bronş dokusunda “in vitro bronkospazm modeli” parasetamolun herhangi etkisi olmazken, iboprofenin beklenilenin aksine istatistiksel olarak anlamlı oranda gevşeme cevabı verdiğini saptadık. Sonuç olarak eğer in vivo çalışmalarla da desteklenirse klinik olarak bronkospazm riski yüksek olan hastalarda ibuprofenin parasetamolden daha öncelikli olarak tercih edilebileceğini düşünmekteyiz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Erdem A, Karaca Ozkisacik S, Yazici M, Erel V (2019). The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. , 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| Chicago | Erdem Ali Onur,Karaca Ozkisacik Sezen,Yazici Mesut,Erel Varlik K. The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. (2019): 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| MLA | Erdem Ali Onur,Karaca Ozkisacik Sezen,Yazici Mesut,Erel Varlik K. The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. , 2019, ss.82 - 86. 10.4274/meandros.galenos.2018.72692 |
| AMA | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. . 2019; 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| Vancouver | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. . 2019; 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| IEEE | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V "The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study." , ss.82 - 86, 2019. 10.4274/meandros.galenos.2018.72692 |
| ISNAD | Erdem, Ali Onur vd. "The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study". (2019), 82-86. https://doi.org/10.4274/meandros.galenos.2018.72692 |
| APA | Erdem A, Karaca Ozkisacik S, Yazici M, Erel V (2019). The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. Meandros Medical And Dental Journal, 20(1), 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| Chicago | Erdem Ali Onur,Karaca Ozkisacik Sezen,Yazici Mesut,Erel Varlik K. The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. Meandros Medical And Dental Journal 20, no.1 (2019): 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| MLA | Erdem Ali Onur,Karaca Ozkisacik Sezen,Yazici Mesut,Erel Varlik K. The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. Meandros Medical And Dental Journal, vol.20, no.1, 2019, ss.82 - 86. 10.4274/meandros.galenos.2018.72692 |
| AMA | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. Meandros Medical And Dental Journal. 2019; 20(1): 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| Vancouver | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study. Meandros Medical And Dental Journal. 2019; 20(1): 82 - 86. 10.4274/meandros.galenos.2018.72692 |
| IEEE | Erdem A,Karaca Ozkisacik S,Yazici M,Erel V "The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study." Meandros Medical And Dental Journal, 20, ss.82 - 86, 2019. 10.4274/meandros.galenos.2018.72692 |
| ISNAD | Erdem, Ali Onur vd. "The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study". Meandros Medical And Dental Journal 20/1 (2019), 82-86. https://doi.org/10.4274/meandros.galenos.2018.72692 |
