Bediha AKMESE
(Hitit Üniversitesi, Kimya Bölümü, Çorum, Türkiye)
Yıl: 2020Cilt: 7Sayı: 1ISSN: 2149-2123 / 2148-4171Sayfa Aralığı: 51 - 54İngilizce

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Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC
Stress degradation studies control the behavior and impurities of drugs under variousstress conditions. The present research is related to all degradation studies includingacidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization (ICH) guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin (ROX), tilmicosin (TIL) and tylosin (TYL)”under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performanceliquid chromatography (HPLC).
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