Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

AKMESE, BEDIHA

doi:10.17350/HJSE19030000172

Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

Bediha AKMESE (Hitit Üniversitesi, Kimya Bölümü, Çorum, Türkiye)

Hittite Journal of Science and Engineering

12 3

Yıl: 2020 Cilt: 7 Sayı: 1 Sayfa Aralığı: 51 - 54 Metin Dili: İngilizce DOI: 10.17350/HJSE19030000172 İndeks Tarihi: 18-10-2020

Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

Öz:

Stress degradation studies control the behavior and impurities of drugs under variousstress conditions. The present research is related to all degradation studies includingacidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization (ICH) guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin (ROX), tilmicosin (TIL) and tylosin (TYL)”under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performanceliquid chromatography (HPLC).

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKMESE B (2020). Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. , 51 - 54. 10.17350/HJSE19030000172
Chicago	AKMESE BEDIHA Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. (2020): 51 - 54. 10.17350/HJSE19030000172
MLA	AKMESE BEDIHA Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. , 2020, ss.51 - 54. 10.17350/HJSE19030000172
AMA	AKMESE B Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. . 2020; 51 - 54. 10.17350/HJSE19030000172
Vancouver	AKMESE B Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. . 2020; 51 - 54. 10.17350/HJSE19030000172
IEEE	AKMESE B "Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC." , ss.51 - 54, 2020. 10.17350/HJSE19030000172
ISNAD	AKMESE, BEDIHA. "Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC". (2020), 51-54. https://doi.org/10.17350/HJSE19030000172

APA	AKMESE B (2020). Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. Hittite Journal of Science and Engineering, 7(1), 51 - 54. 10.17350/HJSE19030000172
Chicago	AKMESE BEDIHA Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. Hittite Journal of Science and Engineering 7, no.1 (2020): 51 - 54. 10.17350/HJSE19030000172
MLA	AKMESE BEDIHA Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. Hittite Journal of Science and Engineering, vol.7, no.1, 2020, ss.51 - 54. 10.17350/HJSE19030000172
AMA	AKMESE B Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. Hittite Journal of Science and Engineering. 2020; 7(1): 51 - 54. 10.17350/HJSE19030000172
Vancouver	AKMESE B Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC. Hittite Journal of Science and Engineering. 2020; 7(1): 51 - 54. 10.17350/HJSE19030000172
IEEE	AKMESE B "Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC." Hittite Journal of Science and Engineering, 7, ss.51 - 54, 2020. 10.17350/HJSE19030000172
ISNAD	AKMESE, BEDIHA. "Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC". Hittite Journal of Science and Engineering 7/1 (2020), 51-54. https://doi.org/10.17350/HJSE19030000172