Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

AKMESE ,Bediha

doi:10.17350/HJSE19030000172

Bediha AKMESE

(Hitit Üniversitesi, Kimya Bölümü, Çorum, Türkiye)

Hittite Journal of Science and Engineering

Yıl: 2020Cilt: 7Sayı: 1ISSN: 2149-2123 / 2148-4171Sayfa Aralığı: 51 - 54Metin Dili: İngilizce

DOI: https://doi.org/10.17350/HJSE19030000172

81 0

İngilizce

Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

Abstract: Stress degradation studies control the behavior and impurities of drugs under variousstress conditions. The present research is related to all degradation studies includingacidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization (ICH) guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin (ROX), tilmicosin (TIL) and tylosin (TYL)”under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performanceliquid chromatography (HPLC).

Keywords:

Subject Area:

Belge Türü: DergiMakale Türü: Araştırma MakalesiErişim Formatı: Erişime Açık

1. Rensen B.H. Algal toxicity of antibacterial agents used in intensive farming. Chemosphere 40 (2000) 731–739.
2. Ying GG, He LY, Ying AJ, Zhang QQ, Liu YS, Zhao JL. China must reduce its antibiotic use. Environmental Science & Technology 51 (2017) 1072–1073.
3. Chun-Xiang L, Han J, Wang Y, Yong-Sheng Y, Xiao-Hui X, JianMing P, Analytica Chimica Acta 653 (2009) 178–183.
4. Zhang H, Lu Y, Zhang G, Gao S, Sun D, Zhong Y. Bupivacaineloaded biodegradable poly(lactic-co-glycolic) acid microspheres I. Optimization of the drug incorporation into the polymer matrix and modelling of drug release. International Journal of Pharmaceutics 351 (2008) 244–249.
5. Yang Y, Yuan L, Li J, Muhammad I, Cheng P, Xiao T, Zhang X. Preparation and evaluation of tilmicosin microspheres and lungtargeting studies in rabbits. The Veterinary Journal 246 (2019) 27–34.
6. Cheng J, Ye Q, Yang Z, Yang W, Zhou J, Cen K. Chlorella PYZU1 during tilmicosin removal from wastewater under 15% CO2. Journal of Hazardous Materials 324 (2017) 414–419.
7. Paesen J, Cypers W, Busson R, Roets E, Hoogmartens J. Isolation of decomposition products of tylosin using liquid chromatography, Journal of Chromatography A 699 (1995) 99–106.
8. Daugherty AL, Mrsny RJ. Formulation and delivery issues for monoclonal antibody therapeutics, Advanced Drug Delivery Reviews 58 (2006) 686–706.
9. Filipe V, Hawe A, Carpenter JF, Jiskoot W. Analytical approaches to assess the degradation of therapeutic proteins, Trac-Trends in Analytical Chemistry 49 (2013) 118–125.
10. Tamizi E, Jouyban A. Forced degradation studies of biopharmaceuticals: Selection of stress conditions. European Journal of Pharmaceutics and Biopharmaceutics 98 (2016) 26–46.
11. Wahba MEK. Liquid chromatographic determination of roxithromycin: application to stability studies. Journal of Chromatographic Science 51 (2013) 44–52.
12. Prats C, Francesch R, Arboix M, Pérez B. Determination of tylosin residues in different animal tissues by high performance liquid chromatography. Journal of Chromatography B 766 (2001) 57-65.
13. Zhang Y, Pan Z, Ronga C, Shao Y, Wang Y, Yu K. Transformation of antibacterial agent roxithromycin in sodium hypochlorite disinfection process of different water matrices. Separation and Purification Technology 212 (2019) 528-535.
14. Şanli S, Palabiyik IM, Şanli N, Guzel-Seydim SB, Alsancak G. Optimization of the experimental conditions for macrolide antibiotics in high performance liquid chromatography by using response surface methodology and determination of tylosin in milk samples. Journal of Analytical Chemistry 66 (2011) 838–847.
15. ICH, Stability Testing of New Drug Substances and Products (Q1AR): International Conference on Harmonization, IFPMA, Geneva, 2000.