VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS

Çolak, Ayfer; Bekdik Şirinocak, Pınar; Eskut, Neslihan; Sener, Ufuk; Zorlu, Yasar

VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS

Pınar BEKDİK ŞİRİNOCAK, (Sağlık Bilimleri Üniversitesi, Derince Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, Kocaeli, Türkiye)

Neslihan EŞKUT, (Sağlık Bilimleri Üniversitesi, İzmir Bozyaka Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, İzmir, Türkiye)

Ayfer ÇOLAK, (Sağlık Bilimleri Üniversitesi, İzmir Tepecik Eğitim ve Araştırma Hastanesi, Biyokimya Kliniği, İzmir, Türkiye)

Ufuk ŞENER, (Sağlık Bilimleri Üniversitesi, İzmir Tepecik Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, İzmir, Türkiye)

Yaşar ZORLU (Sağlık Bilimleri Üniversitesi, İzmir Tepecik Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, İzmir, Türkiye)

İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi

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Yıl: 2020 Cilt: 24 Sayı: 2 Sayfa Aralığı: 121 - 126 Metin Dili: İngilizce İndeks Tarihi: 19-10-2020

VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS

Öz:

Introduction: Vitamin D is thought to have a role on multiple sclerosis hence MS cases are less frequent in theareas where exposure to sunlight is high. The idea that vitamin D is related to clinical features and this effect ismore prominent in female patients is controversial. In this study, the relationship between vitamin D levels, proand anti-inflammatory cytokine levels and gender in relapsing-remitting multiple sclerosis patients wereinvestigated. Materials and Methods: 74 patients with relapsing-remitting multiple sclerosis who were in the remission periodwere included in the study. The control group consisted of 50 healthy individuals with similar age and gender.Serum vitamin D, parathormone, interleukin-10 and tumor necrosis factor-α levels were tested in the patient andcontrol groups. The relationship of vitamin D with gender, clinical features and cytokine levels was alsoinvestigated.Results: The mean vitamin D level was 14.4 ng/ml in the patient group and 16 ng/ml in the control group. Thelevels of vitamin D (p: 0,206), Interleukin-10 (p: 0,081), Tumor necrosis factor-α (p: 0,340) and parathormone (p:0,107) were similar in the patient and control groups. Although vitamin D values tended to decrease as clinicalseverity was worsening, this relationship was not statistically significant. Vitamin D levels found to be lower infemale .Conclusion: Vitamin D levels were low in both the patient and control group. There was no correlation betweenvitamin D levels and clinical features.

Anahtar Kelime:

MULTİPL SKLEROZ HASTALARINDA VİTAMİN D, PARATHORMON, CİNSİYET, İNTERLÖKİN 10 VE TÜMÖR NEKROZ FAKTÖR ALFA İLİŞKİSİ

Öz:

Giriş: Güneş ışığına maruziyetin fazla olduğu bölgelerde Multipl Skleroz’un daha az sıklıkla görülmesinde D vitamininin rolü olduğu düşünülmektedir. Vitamin D’nin klinik özellikler ile ilişkisi ve bu etkisinin kadın hastalarda daha belirgin olduğu görüşü tartışmalıdır. Bu çalışmada relapsing-remitting multipl skleroz hastalarında vitamin D, sitokin ve cinsiyet arasındaki ilişki araştırıldı. Gereç ve yöntem: Çalışmaya remisyon döneminde olan 74 Relapsing-remitting multiple skleroz hastası alındı. Kontrol grubu benzer yaş ve cinsiyette 50 sağlıklı bireyden oluşturuldu. Hasta ve kontrol gruplarında serum vitamin D, interlökin-10, tümör nekroz faktör-α ve parathormon düzeyleri ölçüldü. Vitamin D’nin cinsiyet ve klinik özellikler ile ilişkisi araştırıldı. Bulgular: Ortalama vitamin D düzeyi hasta grubunda 14.4 ng/ml, kontrol grubunda 16 ng/ml olarak saptandı. Hasta ve kontrol gruplarında vitamin D (p:0.206), Interlökin-10 (p:0.081), tümör nekroz faktör-α (p: 0,340) ve parathormon (p:0.107) düzeyleri benzer bulundu. Klinik ağırlaştıkça vitamin D düzeyinin düşme eğiliminde olduğu gözlendi ise de bu ilişki istatistiksel anlamlılığa ulaşmadı. Kadınlarda vitamin D düzeyi daha düşük saptandı. Sonuç: Hem hasta hem de kontrol grubunda vitamin D düzeyi düşüktü ve vitamin D klinik özellikler ile ilişkili bulunmadı.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Bekdik Şirinocak P, Eskut N, Çolak A, Sener U, Zorlu Y (2020). VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. , 121 - 126.
Chicago	Bekdik Şirinocak Pınar,Eskut Neslihan,Çolak Ayfer,Sener Ufuk,Zorlu Yasar VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. (2020): 121 - 126.
MLA	Bekdik Şirinocak Pınar,Eskut Neslihan,Çolak Ayfer,Sener Ufuk,Zorlu Yasar VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. , 2020, ss.121 - 126.
AMA	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. . 2020; 121 - 126.
Vancouver	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. . 2020; 121 - 126.
IEEE	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y "VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS." , ss.121 - 126, 2020.
ISNAD	Bekdik Şirinocak, Pınar vd. "VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS". (2020), 121-126.

APA	Bekdik Şirinocak P, Eskut N, Çolak A, Sener U, Zorlu Y (2020). VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, 24(2), 121 - 126.
Chicago	Bekdik Şirinocak Pınar,Eskut Neslihan,Çolak Ayfer,Sener Ufuk,Zorlu Yasar VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 24, no.2 (2020): 121 - 126.
MLA	Bekdik Şirinocak Pınar,Eskut Neslihan,Çolak Ayfer,Sener Ufuk,Zorlu Yasar VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, vol.24, no.2, 2020, ss.121 - 126.
AMA	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020; 24(2): 121 - 126.
Vancouver	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020; 24(2): 121 - 126.
IEEE	Bekdik Şirinocak P,Eskut N,Çolak A,Sener U,Zorlu Y "VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS." İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, 24, ss.121 - 126, 2020.
ISNAD	Bekdik Şirinocak, Pınar vd. "VITAMIN D, PARATHORMONE, GENDER, INTERLEUKIN 10 AND TUMOR NECROSIS ALPHA RELATIONSHIP IN MULTIPLE SCLEROSIS PATIENTS". İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 24/2 (2020), 121-126.