Hypophysitis is an autoimmune heterogeneous inflammatory disease of the pituitary gland. It is seen in two forms being primary and secondary. Lymphocytic hypophysitis is the most commonly observed form of hypophysitis and it is a disease capable of disrupting the hormonal secretions of the pituitary gland, imitating pituitary adenomas, and sometimes even causes mortality due to pituitary failure. The purpose of the treatment is to reduce the existing symptoms, to minimize the hypophyseal tumor and to eliminate the resultant hormonal deficiencies. The most commonly used medications in medical treatment are the glucocorticoids and they ensure minimization of the pituitary gland and improve pituitary function. In cases of glucocorticoids inadequacy, the other immunosuppressive medications, such as azathioprine, methotrexate and cyclosporine A, might be used. Surgical treatment might be necessary in some cases. In this evaluation, in the light of most up-to-date literature information, classification of hypophysitis, its clinical importance and treatment approaches are discussed.