First trimester complete blood cell indices in early and late onset preeclampsia

Orgul, Gokcen; Beksac, M.Sinan; Fadiloglu, Erdem; Ozten, Gonca; Aydin Hakli, Duygu; Tanacan, Atakan

doi:10.4274/tjod.galenos.2019.93708

First trimester complete blood cell indices in early and late onset preeclampsia

Gökçen ÖRGÜL, (Hacettepe Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Perinatoloji Bilim Dalı, Ankara, Türkiye)

Duygu AYDIN HAKLI, (Hacettepe Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Ankara, Türkiye)

Gonca ÖZTEN, (Hacettepe Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Perinatoloji Bilim Dalı, Ankara, Türkiye)

Erdem FADİLOĞLU, (Hacettepe Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Perinatoloji Bilim Dalı, Ankara, Türkiye)

Atakan TANACAN, (Hacettepe Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Perinatoloji Bilim Dalı, Ankara, Türkiye)

Mehmet Sinan BEKSAÇ (Hacettepe Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Perinatoloji Bilim Dalı, Ankara, Türkiye)

Turkish Journal of Obstetrics and Gynecology

19 4

Yıl: 2019 Cilt: 16 Sayı: 2 Sayfa Aralığı: 112 - 117 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2019.93708 İndeks Tarihi: 20-10-2020

First trimester complete blood cell indices in early and late onset preeclampsia

Öz:

Objective: This study aimed to compare the first trimester complete blood count (CBC) indices of pregnancies complicated by early-onset preeclampsia(EOPE) or late-onset preeclampsia (LOPE).Material and Methods: A retrospective case-control study was conducted with 186 patients. Patients were classified into three subgroups: EOPE,LOPE, and control groups. First trimester CBC results were obtained for each patient. Hemoglobin, hematocrit, red blood cell distribution width, meancorpuscular volume, white blood cell (WBC) count, neutrophil, eosinophil, basophil, lymphocyte, monocyte, mean platelet volume, platelet distributionwidth, plateletcrit, and platelet count were compared. The neutrophil lymphocyte ratio was calculated by dividing the absolute lymphocyte count by theabsolute neutrophil count. The platelet lymphocyte ratio was calculated by dividing the absolute lymphocyte count by the absolute platelet count.Results: The total number of cases was 21, 42, and 123, in the EOPE, LOPE, and control groups, respectively. There were statistically significant differencesin the total WBC and neutrophil counts between the three groups (both p<0.05). WBC and neutrophil counts were found to be highest in the EOPE group,and the LOPE group had higher levels compared with controls. The optimal cut-off values to predict EOPE for WBC and neutrophil counts were 9.55×103/μL (sensitivity 71.4% and specificity 70.7%) and 6.45×103/μL (sensitivity 66.7% and specificity 74.8%), respectively.Conclusion: Increased first trimester WBC and neutrophil counts may be predictive for EOPE.

Anahtar Kelime:

Erken ve geç başlangıçlı preeklampside ilk trimester tam kan sayım parametreleri

Öz:

Amaç: Bu çalışma ile erken başlangıçlı preeklampsi (EOPE) veya geç başlangıçlı preeklampsi (LOPE) ile komplike olan gebeliklerin ilk trimester tam kan sayımı (CBC) parametrelerinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Retrospektif olarak 186 hasta ile olgu kontrol çalışması yapıldı. Hastalar EOPE, LOPE ve kontrol grubu olmak üzere üç alt gruba ayrıldı. Her hasta için ilk trimester CBC sonuçları incelendi. Hemoglobin, hematokrit, kırmızı kan hücreleri dağılım genişliği, ortalama korpüsküler hacim, beyaz kan hücresi (WBC), nötrofil, eozinofil, bazofil, lenfosit, monosit, ortalama trombosit hacmi, trombosit dağılım genişliği, platelekrit ve trombosit sayımı karşılaştırıldı. Nötrofil lenfosit oranı, mutlak lenfosit sayısının mutlak nötrofil sayısına bölünmesiyle hesaplandı. Trombosit lenfosit oranı, mutlak lenfosit sayısının mutlak trombosit sayısına bölünmesiyle hesaplandı. Bulgular: Toplam olgu sayısı EOPE, LOPE ve kontrol gruplarında sırasıyla 21, 42 ve 123 idi. Üç grup arasında toplam WBC ve nötrofil sayısı açısından istatistiksel olarak anlamlı fark saptandı (p<0,05). WBC ve nötrofil sayıları EOPE grubunda en yüksek, LOPE grubunda ise kontrollere göre daha yüksek bulundu. WBC ve nötrofil sayısı için EOPE’yi tahmin etmek için en uygun kesme değerleri sırasıyla 9,55×103/μL (duyarlılık %71,4 ve özgüllük %70,7) ve 6,45×103/μL (duyarlılık %66,7 ve özgüllük %74,8) idi. Sonuç: Artan birinci trimester WBC ve nötrofil sayıları EOPE için öngörücü olabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Orgul G, Aydin Hakli D, Ozten G, Fadiloglu E, Tanacan A, Beksac M (2019). First trimester complete blood cell indices in early and late onset preeclampsia. , 112 - 117. 10.4274/tjod.galenos.2019.93708
Chicago	Orgul Gokcen,Aydin Hakli Duygu,Ozten Gonca,Fadiloglu Erdem,Tanacan Atakan,Beksac M.Sinan First trimester complete blood cell indices in early and late onset preeclampsia. (2019): 112 - 117. 10.4274/tjod.galenos.2019.93708
MLA	Orgul Gokcen,Aydin Hakli Duygu,Ozten Gonca,Fadiloglu Erdem,Tanacan Atakan,Beksac M.Sinan First trimester complete blood cell indices in early and late onset preeclampsia. , 2019, ss.112 - 117. 10.4274/tjod.galenos.2019.93708
AMA	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M First trimester complete blood cell indices in early and late onset preeclampsia. . 2019; 112 - 117. 10.4274/tjod.galenos.2019.93708
Vancouver	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M First trimester complete blood cell indices in early and late onset preeclampsia. . 2019; 112 - 117. 10.4274/tjod.galenos.2019.93708
IEEE	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M "First trimester complete blood cell indices in early and late onset preeclampsia." , ss.112 - 117, 2019. 10.4274/tjod.galenos.2019.93708
ISNAD	Orgul, Gokcen vd. "First trimester complete blood cell indices in early and late onset preeclampsia". (2019), 112-117. https://doi.org/10.4274/tjod.galenos.2019.93708

APA	Orgul G, Aydin Hakli D, Ozten G, Fadiloglu E, Tanacan A, Beksac M (2019). First trimester complete blood cell indices in early and late onset preeclampsia. Turkish Journal of Obstetrics and Gynecology, 16(2), 112 - 117. 10.4274/tjod.galenos.2019.93708
Chicago	Orgul Gokcen,Aydin Hakli Duygu,Ozten Gonca,Fadiloglu Erdem,Tanacan Atakan,Beksac M.Sinan First trimester complete blood cell indices in early and late onset preeclampsia. Turkish Journal of Obstetrics and Gynecology 16, no.2 (2019): 112 - 117. 10.4274/tjod.galenos.2019.93708
MLA	Orgul Gokcen,Aydin Hakli Duygu,Ozten Gonca,Fadiloglu Erdem,Tanacan Atakan,Beksac M.Sinan First trimester complete blood cell indices in early and late onset preeclampsia. Turkish Journal of Obstetrics and Gynecology, vol.16, no.2, 2019, ss.112 - 117. 10.4274/tjod.galenos.2019.93708
AMA	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M First trimester complete blood cell indices in early and late onset preeclampsia. Turkish Journal of Obstetrics and Gynecology. 2019; 16(2): 112 - 117. 10.4274/tjod.galenos.2019.93708
Vancouver	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M First trimester complete blood cell indices in early and late onset preeclampsia. Turkish Journal of Obstetrics and Gynecology. 2019; 16(2): 112 - 117. 10.4274/tjod.galenos.2019.93708
IEEE	Orgul G,Aydin Hakli D,Ozten G,Fadiloglu E,Tanacan A,Beksac M "First trimester complete blood cell indices in early and late onset preeclampsia." Turkish Journal of Obstetrics and Gynecology, 16, ss.112 - 117, 2019. 10.4274/tjod.galenos.2019.93708
ISNAD	Orgul, Gokcen vd. "First trimester complete blood cell indices in early and late onset preeclampsia". Turkish Journal of Obstetrics and Gynecology 16/2 (2019), 112-117. https://doi.org/10.4274/tjod.galenos.2019.93708