Yıl: 2020 Cilt: 24 Sayı: 3 Sayfa Aralığı: 230 - 236 Metin Dili: İngilizce DOI: 10.25179/tjem.2020-74747 İndeks Tarihi: 20-10-2020

The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma

Öz:
Objective: The aim of this study was to determine whetherthyroid-stimulating hormone (TSH) levels during the diagnosisof patients with differentiated thyroid carcinoma couldbe used for the prediction of cancer behavior. Material andMethods: The records of 329 patients with differentiatedthyroid carcinoma who did not use levothyroxine at the timeof diagnosis were reviewed retrospectively. The demographicand clinical characteristics of the cases and serum TSHlevels were recorded at the time of diagnosis and statisticallyanalyzed. Results: A total of 329 cases with 322 papillarycarcinomas and 7 follicular carcinomas were includedin the study. The median age of the participants at the timeof diagnosis was 45 (17-76) years. Eighty-three percent ofthe cases were diagnosed in stage 1, 6.7% in stage 2, 3.3%in stage 3, and 7.0% in stage 4. The median serum TSHlevel at the time of diagnosis of the cases was 1.34 (0.01-9.97) mIU/mL. We did not observe any statistically significantrelationship between the serum TSH level and thestage of differentiated thyroid carcinoma, although higherserum TSH level was associated with lymph node metastasisand higher risk group in the American Thyroid Association(ATA) classification. Conclusion: The relationshipbetween serum TSH level and thyroid cancer has not beenclearly determined, but high TSH levels at the time of diagnosiswere found to be associated with lymph node metastasisand medium-high ATA risk score.
Anahtar Kelime:

Diferansiye Tiroid Karsinomunun Evresi ile TSH Düzeyi Arasındaki İlişki

Öz:
Amaç: Bu çalışmanın amacı, diferansiye tiroid karsinomlu hastaların tanı anındaki tiroid stimüle edici hormon (TSH) düzeylerinin kanser davranışını tahmin etmek için kullanılıp kullanılamayacağını belirlemekti. Gereç ve Yöntemler: Çalışmada tanı anında levotiroksin kullanmayan diferansiye tiroid karsinomlu 329 hastanın kayıtları retrospektif olarak incelendi. Olguların demografik ve klinik özellikleri ile tanı anındaki serum TSH düzeyleri kaydedildi ve istatistiksel olarak analiz edildi. Bulgular: Çalışmaya, toplam 329 (322'si papiller, 7'si foliküler karsinomlu) olgu dâhil edildi. Katılımcıların tanı anındaki ortanca yaşı 45 (17-76) yıl idi. Olguların %83'ü evre 1, %6,7'si evre 2, %3,3'ü evre 3 ve %7,0'ı evre 4 olarak teşhis edildi. Olguların tanı anında medyan serum TSH düzeyi 1,34 (0,01-9,97) mIU/mL idi. Serum TSH düzeyi ile diferansiye tiroid karsinomunun evresi arasında istatistiksel olarak anlamlı bir ilişki gözlemlemedik, ancak yüksek serum TSH düzeyi, "American Thyroid Association (ATA)" sınıflandırmasına göre lenf nodu metastazı ile ilişkili bulunmuştur. Sonuç: Serum TSH düzeyi ile tiroid kanseri arasındaki ilişki net olarak belirlenmemiştir, ancak tanı anındaki yüksek TSH düzeyleri lenf nodu metastazı ve orta-yüksek ATA risk skoru ile ilişkili bulunmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Tunçez E, Kulaksizoglu M, Tunçez İ (2020). The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. , 230 - 236. 10.25179/tjem.2020-74747
Chicago Tunçez Esra,Kulaksizoglu Mustafa,Tunçez İsmail Hakkı The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. (2020): 230 - 236. 10.25179/tjem.2020-74747
MLA Tunçez Esra,Kulaksizoglu Mustafa,Tunçez İsmail Hakkı The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. , 2020, ss.230 - 236. 10.25179/tjem.2020-74747
AMA Tunçez E,Kulaksizoglu M,Tunçez İ The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. . 2020; 230 - 236. 10.25179/tjem.2020-74747
Vancouver Tunçez E,Kulaksizoglu M,Tunçez İ The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. . 2020; 230 - 236. 10.25179/tjem.2020-74747
IEEE Tunçez E,Kulaksizoglu M,Tunçez İ "The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma." , ss.230 - 236, 2020. 10.25179/tjem.2020-74747
ISNAD Tunçez, Esra vd. "The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma". (2020), 230-236. https://doi.org/10.25179/tjem.2020-74747
APA Tunçez E, Kulaksizoglu M, Tunçez İ (2020). The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. Turkish Journal of Endocrinology and Metabolism, 24(3), 230 - 236. 10.25179/tjem.2020-74747
Chicago Tunçez Esra,Kulaksizoglu Mustafa,Tunçez İsmail Hakkı The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. Turkish Journal of Endocrinology and Metabolism 24, no.3 (2020): 230 - 236. 10.25179/tjem.2020-74747
MLA Tunçez Esra,Kulaksizoglu Mustafa,Tunçez İsmail Hakkı The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. Turkish Journal of Endocrinology and Metabolism, vol.24, no.3, 2020, ss.230 - 236. 10.25179/tjem.2020-74747
AMA Tunçez E,Kulaksizoglu M,Tunçez İ The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. Turkish Journal of Endocrinology and Metabolism. 2020; 24(3): 230 - 236. 10.25179/tjem.2020-74747
Vancouver Tunçez E,Kulaksizoglu M,Tunçez İ The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma. Turkish Journal of Endocrinology and Metabolism. 2020; 24(3): 230 - 236. 10.25179/tjem.2020-74747
IEEE Tunçez E,Kulaksizoglu M,Tunçez İ "The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma." Turkish Journal of Endocrinology and Metabolism, 24, ss.230 - 236, 2020. 10.25179/tjem.2020-74747
ISNAD Tunçez, Esra vd. "The Relationship Between TSH Level and Stage of Differentiated Thyroid Carcinoma". Turkish Journal of Endocrinology and Metabolism 24/3 (2020), 230-236. https://doi.org/10.25179/tjem.2020-74747