Pheochromocytoma is an adrenal medulla-derived tumororiginating from the chromaffin cells that produce and secretecatecholamines. These tumors usually occur sporadically,but they may also be associated with genetic diseases,such as multiple endocrine neoplasia syndrome type 2 (MEN2). A hypertensive crisis that occurs after the spontaneousrupture of pheochromocytoma, is a rare clinical complicationwith a high mortality rate. In this article, we present a malecase who developed hypertensive crisis and thrombotic microangiopathy(TMA) after a spontaneous pheochromocytomarupture due to MEN 2A.