In the 19th century while the idea was fabricated and the standard of living was synchronized with individual efforts, a community was formed from individuals who were unaware of each other, the emergence of endemic diseases with epidemic and pandemic characteristics was facilitated in this upheaval. The removal of this threat to the general structure of the system has been attempted with investments towards public health. However, the reverse ratio between the short-term dimension of the threat from epidemics and the need for a long process of investments that prioritize public health has brought alternative methods and practices to the agenda. At the beginning of the mentioned alternative procedures, which are related to the legacy of the ancients, was the quarantine procedure and the cordon application. The Ottoman Empire, which was one of the countries with the greatest geographical boundaries of the century, did not have the factories of the idea and the societies formed around these structures. But the fact that it constitutes one of the largest parts of the shrinking world has laid the groundwork for the threat of epidemics such as cholera. Public Health Investments, which will be conditioned to remove the threat mentioned in industrializing countries, are also in question in the Ottoman state, but the reasons in the aforementioned countries are also valid in terms of the Ottoman world caused priority to be given to quarantine and Cordon procedures. The most important part of this painting was the practices established in Van and its surroundings. Efforts towards the execution of the aforementioned procedures and practices by taking into account the characteristics and sensitivities of the region subject to research have been tried to be embodied by reviewing the secondary sources, especially the archive documents.