Evaluation of Posterior Ocular Structures in Patients with Schizophrenia

karaaslan, özgül; Bayhan, Hasan Ali; Hacımusalar, Yunus; Küçük, Bekir; Aslan Bayhan, Seray

doi:10.16919/bozokti.566862

Evaluation of Posterior Ocular Structures in Patients with Schizophrenia

Bekir KÜÇÜK, (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Oftalmoloji Anabilim Dalı, Yozgat, Türkiye)

Özgül KARAASLAN, (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Yozgat, Türkiye)

Yunus HACIMUSALAR, (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Yozgat, Türkiye)

Seray Aslan BAYHAN, (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Oftalmoloji Anabilim Dalı, Yozgat, Türkiye)

Hasan Ali BAYHAN (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Oftalmoloji Anabilim Dalı, Yozgat, Türkiye)

Bozok Tıp Dergisi

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Yıl: 2019 Cilt: 9 Sayı: 3 Sayfa Aralığı: 108 - 114 Metin Dili: İngilizce DOI: 10.16919/bozokti.566862 İndeks Tarihi: 25-10-2020

Evaluation of Posterior Ocular Structures in Patients with Schizophrenia

Öz:

Purpose: We aimed to evaluate the effcts of schizophrenia on posterior ocular structures including theretial nerve fier layer (RNFL), central macular thickness (CMT), choroidal thickness (CT) and laminacribrosa (LC) measurements.Methods: A total of 35 patints with schizophrenia and 35 healthy individuals were enrolled. Only the righteye of each partiipant was tested. RNFL thickness in all quadrants, CT, CMT, LC thickness, and LC depth(LCD) measurements were performed using Fourier domain opti coherence tomography (OCT), and eachvariable was compared between groups.Results: The mean age and sex distributins were similar between groups (p=0.528 and p=0.299,respectiely). The average, superior, inferior, nasal, and temporal RNFL thicknesses were signifiantly lower inschizophrenia patints than in controls (p<0.001, p<0.001, p=0.001, p=0.002 and p<0.001, respectiely). Themean subfoveal and perifoveal CT were not signifiantly diffrent between the groups (subfoveal; p=0.676,1.5 mm nasal; p=0.632, 3 mm nasal; p=1.000, 1.5 mm temporal; p=0.811, 3 mm temporal; p=0.145). Themean CMT was similar among the groups (p=0.678). LC thickness and LCD were not statitially signifiantbetween groups (p=0.816 and p=0.161).Conclusions: We demonstrated that RNFL thicknesses in all quadrants were signifiantly lower inschizophrenia patints than in control subjects. However, there were no signifiant diffrences in the CMT,perifoveal and subfoveal CT, LC thickness, and LCD between the groups. These results suggest that OCT canbe used to image neuronal loss by evaluatig the RNFL in patints with schizophrenia

Anahtar Kelime:

ŞİZOFRENİ HASTALARINDA GÖZÜN ARKA SEGMENT YAPILARININ DEĞERLENDİRİLMESİ

Öz:

Amaç: Bu çalışmada, şizofreni hastalığının gözün arka segment yapılarından retia sinir lif tabakası (RSLT), santral makülar kalınlık (SMK), koroidal kalınlık (KK) ve lamina kribroza (LK) ölçümleri üzerine etkisinin de- ğerlendirilmesi amaçlanmıştı. Gereç ve Yöntemler: Çalışmaya şizofrenisi bulunan 35 hasta ve 35 sağlıklı katıımcı dahil edilmişti. Her hastanın yalnızca sağ gözü çalışılmıştı. Fourier domain opti koherens tomograf (OKT) ile her kadrandan RSLT kalınlığı, KK, SMK, LK kalınlığı ve LK derinliği (LKD) ölçümleri yapılmıştı ve her değer gruplar arasında karşı- laştıılmıştı. Bulgular: Gruplar arasında ortalama yaş ve cinsiyet dağılımları benzerdi (p=0.528 ve p=0.299). Ortalama, superior, inferior, nazal ve temporal RSLT kalınlıkları şizofrenisi bulunan hastalarda, kontrollere göre anlamlı olarak düşüktü (sırasıyla; p<0.001, p<0.001, p=0.001, p=0.002 ve p<0.001). Fovea alt ve çevresindeki ortalama KK ölçümleri gruplar arasında anlamlı farklılık göstermiyordu (fovea altı p=0.676, 1.5 mm nazal; p=0.632, 3 mm nazal; p=1.000, 1.5 mm temporal; p=0.811, 3 mm temporal; p=0.145). Ortalama SMK gruplar arasında benzerdi (p=0.678). LK kalınlığı ve LKD, gruplar arasında istatitisel açıdan anlamlı farklılık göstermiyordu (p=0.816 ve p=0.161). Sonuçlar: Tüm kadranlardaki RSLT kalınlıkları şizofreni hastalarında kontrol grubuna göre anlamlı şekilde düşüktü. Fakat SMK, fovea alt ve çevresi KK, LK kalınlığı ve LKD ölçümlerinde gruplar arasında anlamlı fark yoktu. Bu bulgular şizofreni hastalarında nöron kayıplarının görüntülenmesinde, RSLT kalınlığının değerlendirildiği OKT’nin kullanılabileceğini gösterdi

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Küçük B, karaaslan ö, Hacımusalar Y, Aslan Bayhan S, Bayhan H (2019). Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. , 108 - 114. 10.16919/bozokti.566862
Chicago	Küçük Bekir,karaaslan özgül,Hacımusalar Yunus,Aslan Bayhan Seray,Bayhan Hasan Ali Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. (2019): 108 - 114. 10.16919/bozokti.566862
MLA	Küçük Bekir,karaaslan özgül,Hacımusalar Yunus,Aslan Bayhan Seray,Bayhan Hasan Ali Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. , 2019, ss.108 - 114. 10.16919/bozokti.566862
AMA	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. . 2019; 108 - 114. 10.16919/bozokti.566862
Vancouver	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. . 2019; 108 - 114. 10.16919/bozokti.566862
IEEE	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H "Evaluation of Posterior Ocular Structures in Patients with Schizophrenia." , ss.108 - 114, 2019. 10.16919/bozokti.566862
ISNAD	Küçük, Bekir vd. "Evaluation of Posterior Ocular Structures in Patients with Schizophrenia". (2019), 108-114. https://doi.org/10.16919/bozokti.566862

APA	Küçük B, karaaslan ö, Hacımusalar Y, Aslan Bayhan S, Bayhan H (2019). Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. Bozok Tıp Dergisi, 9(3), 108 - 114. 10.16919/bozokti.566862
Chicago	Küçük Bekir,karaaslan özgül,Hacımusalar Yunus,Aslan Bayhan Seray,Bayhan Hasan Ali Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. Bozok Tıp Dergisi 9, no.3 (2019): 108 - 114. 10.16919/bozokti.566862
MLA	Küçük Bekir,karaaslan özgül,Hacımusalar Yunus,Aslan Bayhan Seray,Bayhan Hasan Ali Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. Bozok Tıp Dergisi, vol.9, no.3, 2019, ss.108 - 114. 10.16919/bozokti.566862
AMA	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. Bozok Tıp Dergisi. 2019; 9(3): 108 - 114. 10.16919/bozokti.566862
Vancouver	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H Evaluation of Posterior Ocular Structures in Patients with Schizophrenia. Bozok Tıp Dergisi. 2019; 9(3): 108 - 114. 10.16919/bozokti.566862
IEEE	Küçük B,karaaslan ö,Hacımusalar Y,Aslan Bayhan S,Bayhan H "Evaluation of Posterior Ocular Structures in Patients with Schizophrenia." Bozok Tıp Dergisi, 9, ss.108 - 114, 2019. 10.16919/bozokti.566862
ISNAD	Küçük, Bekir vd. "Evaluation of Posterior Ocular Structures in Patients with Schizophrenia". Bozok Tıp Dergisi 9/3 (2019), 108-114. https://doi.org/10.16919/bozokti.566862