The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development
Yıl: 2020 Cilt: 58 Sayı: 4 Sayfa Aralığı: 364 - 369 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2020.6162 İndeks Tarihi: 25-10-2020
The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development
Öz: Aim: Primary dysmenorrhea (PD) is among the most commongynecological diseases in young women presenting to emergencydepartment. It has been shown that cytokines played roles in PDpathogenesis. Interleukin-4 (IL-4), a cytokine, regulates multiplebiological functions. The objective of the present study was toexamine possible relationship between IL-4 variable number oftandem repeat (VNTR) polymorphism and susceptibility to PD.Methods: This study was based on a prospective cohortstudy design. A total of 120 patients with PD and 116 healthycontrols, who presented to the emergency department between01.12.2018 and 01.12.2019, were included in the study. IL-4VNTR was genotyped by polymerase chain reaction (PCR). Theresults of the analyses were evaluated in terms of statisticallysignificant differences.Results: The prevalence of genotypes of P1/P1, P1/P2, and P2/P2 for IL-4 VNTR were 1.72%, 34.4%, and 63.7% in patientswith PD, and 0.8%, 26.6%, and 72.5% in controls, respectively.There was no significant difference in distribution of genotypesand allele frequencies of IL-4 VNTR between the groups (p>0.05).Conclusion: This research is the first study to examine therelationship between IL-4 VNTR and PD. The data of the presentstudy did not support a relationship between IL-4 VNTR and PDrisk.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Esen M, Nursal A, DUMAN E, Yigit S (2020). The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. , 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| Chicago | Esen Mehmet,Nursal Ayse Feyda,DUMAN ESRA,Yigit Serbulent The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. (2020): 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| MLA | Esen Mehmet,Nursal Ayse Feyda,DUMAN ESRA,Yigit Serbulent The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. , 2020, ss.364 - 369. 10.4274/haseki.galenos.2020.6162 |
| AMA | Esen M,Nursal A,DUMAN E,Yigit S The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. . 2020; 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| Vancouver | Esen M,Nursal A,DUMAN E,Yigit S The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. . 2020; 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| IEEE | Esen M,Nursal A,DUMAN E,Yigit S "The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development." , ss.364 - 369, 2020. 10.4274/haseki.galenos.2020.6162 |
| ISNAD | Esen, Mehmet vd. "The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development". (2020), 364-369. https://doi.org/10.4274/haseki.galenos.2020.6162 |
| APA | Esen M, Nursal A, DUMAN E, Yigit S (2020). The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. Haseki Tıp Bülteni, 58(4), 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| Chicago | Esen Mehmet,Nursal Ayse Feyda,DUMAN ESRA,Yigit Serbulent The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. Haseki Tıp Bülteni 58, no.4 (2020): 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| MLA | Esen Mehmet,Nursal Ayse Feyda,DUMAN ESRA,Yigit Serbulent The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. Haseki Tıp Bülteni, vol.58, no.4, 2020, ss.364 - 369. 10.4274/haseki.galenos.2020.6162 |
| AMA | Esen M,Nursal A,DUMAN E,Yigit S The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. Haseki Tıp Bülteni. 2020; 58(4): 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| Vancouver | Esen M,Nursal A,DUMAN E,Yigit S The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development. Haseki Tıp Bülteni. 2020; 58(4): 364 - 369. 10.4274/haseki.galenos.2020.6162 |
| IEEE | Esen M,Nursal A,DUMAN E,Yigit S "The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development." Haseki Tıp Bülteni, 58, ss.364 - 369, 2020. 10.4274/haseki.galenos.2020.6162 |
| ISNAD | Esen, Mehmet vd. "The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development". Haseki Tıp Bülteni 58/4 (2020), 364-369. https://doi.org/10.4274/haseki.galenos.2020.6162 |
