The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Aras, Omer; KUL, Ayhan

doi:10.5505/vtd.2020.98216

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Ayhan KUL, (Atatürk Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı, Erzurum, Türkiye)

Ömer ARAZ (Atatürk Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Ana Bilim Dalı, Erzurum, Türkiye)

Van Tıp Dergisi

4 0

Yıl: 2020 Cilt: 27 Sayı: 1 Sayfa Aralığı: 50 - 55 Metin Dili: İngilizce DOI: 10.5505/vtd.2020.98216 İndeks Tarihi: 26-10-2020

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Öz:

Introduction: The aim of this study was to assessvitamin D levels in obstructive sleep apnea syndrome(OSAS) and whether there is a relationship between theseverity of the disease and vitamin D.Materials and Methods: In this retrospective study,demographic data, serum 25-Hydroxycholecalciferol [25(OH) D3], parathyroid hormone (PTH), calcium (Ca),phosphate (P), magnesium (Mg) levels and diseaseseverity [mild, moderate and severe OSAS (AHI = 5-15,16-30,> 30 / hour)] of patients diagnosed with OSAS byusing polysomnography [apnea-hypopnea index (AHI>5/hour] and normal patients (AHI <5/hour)] wereevaluated based on hospital records.Results: Of the 293 subjects whose records wereexamined, 229 had OSAS (mean age 55.7 ± 11.3 years;age range 26-86 years), whereas 64 subjects were normal(mean age 55.4 ± 13.7 years; age range 24-78 years). 25(OH) D3 level was significantly lower while BMI andPTH levels were higher in OSAS patients compared tothe control group (p <0.05). 25 (OH) D3 levels weresignificantly lower in patients with severe OSAS (p<0.05). In addition, there was a weak negativerelationship between AHI and 25 (OH) D3 (p: 0.001, r: -0.328), while a weak positive relationship was observedbetween PTH (p: 0.001, r: 0.186) and BMI (p: 0.001, r:0.208).Conclusion: OSAS patients have vitamin D deficiency,and patients especially with severe OSAS have lowervitamin D deficiency. Therefore, We think that makingup of vitamin D deficiency in these patients may bebeneficial in reducing the severity of the disease.

Anahtar Kelime:

Öz:

Amaç: Obstrüktif uyku apne sendromunda (OUAS) D vitamini düzeylerinin belirlenmesi ve hastalık şiddeti ile arasında ilişki olup olmadığı amaçlanmıştır. Gereç ve Yöntem: Bu retrospektif çalışmada OUAS ön tanısı nedeniyle polisomnografi yapılıp tanı konulan [apne-hipopne indeksi (AHİ)>5/saat] ve normal (AHİ<5/saat) olarak değerlendirilen hastaların demografik verileri, serum 25-Hidroksikolekalsiferol [25(OH)D3], paratiroid hormon (PTH), kalsiyum (Ca), fosfat (P), magnezyum (Mg) düzeyleri ve hastalık şiddeti [hafif, orta ve şiddetli OUAS (AHİ=5-15, 16-30, >30/saat)] bilgi işlem kayıtları incelenerek değerlendirildi. Bulgular: Kayıtları incelenen 293 kişinin 229’da OUAS (ortalama yaş 55,7±11,3 yıl; yaş aralığı;26-86 yıl) mevcut iken 64 kişi normal (ortalama yaş 55,4±13,7 yıl; yaş aralığı;24-78 yıl) idi. OUAS hastalarında 25(OH)D3 seviyesinin kontrol grubuna göre anlamlı bir şekilde daha düşük olduğu ve BMI ile PTH seviyelerinin ise daha yüksek olduğu tespit edildi (p<0.05). Şiddetli OUAS hastalarında 25(OH)D3 düzeyinin anlamlı bir şekilde daha düşük seviyedeydi (p<0.05). Ayrıca AHİ ile 25(OH)D3 arasında anlamlı zayıf negatif bir ilişki bulunurken (p:0.001, r:-0.328), PTH (p:0.001, r:0.186) ve BMI (p:0.001, r:0.208) ile arasında ise anlamlı zayıf pozitif bir ilişki tespit edildi. Sonuç: OUAS hastalarında D vitamin eksikliğinin olduğu ve özellikle şiddetli OUAS hastalarında D vitamininin daha düşük olması nedeniyle bu hastalarda D vitamin eksikliğinin yerine konulmasının hastalığın şiddetini azaltmada faydalı olabileceğini düşünmekteyiz

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

1. Al Lawati NM, Patel SR, Ayas NT. Epidemiology, risk factors, and consequences of obstructive sleep apnea and short sleep duration. Prog Cardiovasc Dis 2009; 51(4): 285-293.
2. Archontogeorgis K, Nena E, Papanas N, Steiropoulos P. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med 2014; 2014: 930535.
3. Pafili K, Steiropoulos P, Papanas N. The relationship between obstructive sleep apnoea and coronary heart disease. Curr Opin Cardiol 2015; 30(4): 439-446.
4. McCarty DE, Chesson AL, Jr., Jain SK, Marino AA. The link between vitamin D metabolism and sleep medicine. Sleep Med Rev 2014; 18(4): 311-319.
5. Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. J Am Board Fam Med 2009; 22(6): 698-706.
6. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437(7063): 1257-1263.
7. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012; 8(5): 597-619.
8. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol (1985) 1998; 84(3): 1055-1062.
9. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 2005; 90(7): 4119-4123.
10. Archontogeorgis K, Nena E, Papanas N, Zissimopoulos A, Voulgaris A, Xanthoudaki M, et al. Vitamin D Levels in Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome. Curr Vasc Pharmaco 2018; 16(3): 289-297.
11. Bozkurt NC, Cakal E, Sahin M, Ozkaya EC, Firat H, Delibasi T. The relation of serum 25- hydroxyvitamin-D levels with severity of obstructive sleep apnea and glucose metabolism abnormalities. Endocrine 2012; 41(3): 518-525.
12. Erden ES, Genc S, Motor S, Ustun I, Ulutas KT, Bilgic HK, et al. Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome. Endocrine 2014; 45(2): 311-318.
13. Kerley CP, Hutchinson K, Bolger K, McGowan A, Faul J, Cormican L. Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome. Sleep 2016; 39(2): 293-300.
14. Mete T, Yalcin Y, Berker D, Ciftci B, Guven SF, Topaloglu O, et al. Obstructive sleep apnea syndrome and its association with vitamin D deficiency. J Endocrinol Invest 2013; 36(9): 681-685.
15. Salepci B, Caglayan B, Nahid P, Parmaksiz ET, Kiral N, Fidan A, et al. Vitamin D Deficiency in Patients Referred for Evaluation of Obstructive Sleep Apnea. J Clin Sleep Med 2017; 13(4): 607-612.
16. Goswami U, Ensrud KE, Paudel ML, Redline S, Schernhammer ES, Shikany JM, et al. Vitamin D Concentrations and Obstructive Sleep Apnea in a Multicenter Cohort of Older Males. Ann Am Thorac Soc 2016; 13(5): 712- 718.
17. Barcelo A, Esquinas C, Pierola J, De la Pena M, Sanchez-de-la-Torre M, Montserrat JM, et al. Vitamin D status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration 2013; 86(4): 295-301.
18. Liguori C, Romigi A, Izzi F, Mercuri NB, Cordella A, Tarquini E, et al. Continuous Positive Airway Pressure Treatment Increases Serum Vitamin D Levels in Male Patients with Obstructive Sleep Apnea. J Clin Sleep Med 2015; 11(6): 603-607.
19. Archontogeorgis K, Nena E, Papanas N, Steiropoulos P. The role of vitamin D in obstructive sleep apnoea syndrome. Breathe (Sheff) 2018; 14(3): 206-215.
20. Ziambaras K, Dagogo-Jack S. Reversible muscle weakness in patients with vitamin D deficiency. West J Med 1997; 167(6): 435-439.
21. Sharma V, Borah P, Basumatary LJ, Das M, Goswami M, Kayal AK. Myopathies of endocrine disorders: A prospective clinical and biochemical study. Ann Indian Acad Neurol 2014; 17(3): 298-302.
22. Patil SP, Schneider H, Schwartz AR, Smith PL. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 2007; 132(1): 325-337.
23. Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis 2011; 2(1): 25-37.
24. Igelstrom H, Emtner M, Lindberg E, Asenlof P. Physical activity and sedentary time in persons with obstructive sleep apnea and overweight enrolled in a randomized controlled trial for enhanced physical activity and healthy eating. Sleep Breath 2013; 17(4): 1257-1266.
25. Uygur F, Baki AE, Tanrýverdi H, Örnek T, Atalay F. Serum vitamin D and parathyroid hormone levels in patients with obstructive sleep apnea syndrome. Ýstanbul Med J 2016; 17(2): 0-.

APA	KUL A, Aras O (2020). The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. , 50 - 55. 10.5505/vtd.2020.98216
Chicago	KUL Ayhan,Aras Omer The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. (2020): 50 - 55. 10.5505/vtd.2020.98216
MLA	KUL Ayhan,Aras Omer The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. , 2020, ss.50 - 55. 10.5505/vtd.2020.98216
AMA	KUL A,Aras O The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. . 2020; 50 - 55. 10.5505/vtd.2020.98216
Vancouver	KUL A,Aras O The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. . 2020; 50 - 55. 10.5505/vtd.2020.98216
IEEE	KUL A,Aras O "The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D." , ss.50 - 55, 2020. 10.5505/vtd.2020.98216
ISNAD	KUL, Ayhan - Aras, Omer. "The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D". (2020), 50-55. https://doi.org/10.5505/vtd.2020.98216

APA	KUL A, Aras O (2020). The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. Van Tıp Dergisi, 27(1), 50 - 55. 10.5505/vtd.2020.98216
Chicago	KUL Ayhan,Aras Omer The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. Van Tıp Dergisi 27, no.1 (2020): 50 - 55. 10.5505/vtd.2020.98216
MLA	KUL Ayhan,Aras Omer The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. Van Tıp Dergisi, vol.27, no.1, 2020, ss.50 - 55. 10.5505/vtd.2020.98216
AMA	KUL A,Aras O The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. Van Tıp Dergisi. 2020; 27(1): 50 - 55. 10.5505/vtd.2020.98216
Vancouver	KUL A,Aras O The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D. Van Tıp Dergisi. 2020; 27(1): 50 - 55. 10.5505/vtd.2020.98216
IEEE	KUL A,Aras O "The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D." Van Tıp Dergisi, 27, ss.50 - 55, 2020. 10.5505/vtd.2020.98216
ISNAD	KUL, Ayhan - Aras, Omer. "The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D". Van Tıp Dergisi 27/1 (2020), 50-55. https://doi.org/10.5505/vtd.2020.98216